The Effect of Pulsing Electromagnetic Fields on Bone Ingrowth into a Porous Coated Implant.

Ijiri, Kosei; Matsunaga, Shunji; Fukuyama, Kandai; Yoshikuni, Nagatoshi; Sakou, Takashi; Kitano, Motoo; Senba, Ichiro

doi:10.5035/nishiseisai.43.308

Cited by 16 publications

(26 citation statements)

References 3 publications

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“…15,18,32,38,56,57 It is also believed that the probable mechanism of PEMF includes the promotion of osteogenesis through increased vascularization, collagen production, proliferation and differentiation of osteogenic cells, and increased calcium intake and calcification in the newly formed bone tissue. 15,55,58Y61 We aimed to determine the effects of the combination of PEMF with other agents while the groups were formed, based on the knowledge that the osteogenic effects of PEMF are more when compared with SEMF.…”

Section: Discussionmentioning

confidence: 99%

“…24Y27 Electromagnetic field stimulation decreases problems such as belated recovery or unrecovery problems, which can potentially occur in critical bone defects. 14,15,17 Although the osteogenic effects of these treatment modalities are already known, their combined effect is yet to be clarified. 12 We believe that the present study supports the related studies in the literature and lights the way for new studies.…”

mentioning

confidence: 98%

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Comparison of Effects of Pulsed Electromagnetic Field Stimulation on Platelet-Rich Plasma and Bone Marrow Stromal Stem Cell Using Rat Zygomatic Bone Defect Model

Kapi¹,

Bozkurt

Selçuk

et al. 2015

Annals of Plastic Surgery

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

Comparison of Effects of Pulsed Electromagnetic Field Stimulation on Platelet-Rich Plasma and Bone Marrow Stromal Stem Cell Using Rat Zygomatic Bone Defect Model

Kapi¹,

Bozkurt

Selçuk

et al. 2015

Annals of Plastic Surgery

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“…PEMF have been demonstrated to promote bone ingrowth into titanium and hydroxyapatite-coated implants, but not into tricalcium phosphate implants [6,7,30]. However, the outcome of transmitted application of 5 N/50 Hz for 14 min/day being higher than PEMF-stimulation implies that micro-morphologic properties of bone around implants is not higher than MECHVIB by administration of 0.2 mT 4 h/day PEMF [7].…”

Section: Discussionmentioning

confidence: 99%

Micro-morphologic changes around biophysically-stimulated titanium implants in ovariectomized rats

Akça

Sarac²,

Baysal

et al. 2007

Head Face Med

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BackgroundOsteoporosis may present a risk factor in achievement of osseointegration because of its impact on bone remodeling properties of skeletal phsiology. The purpose of this study was to evaluate micro-morphological changes in bone around titanium implants exposed to mechanical and electrical-energy in osteoporotic rats.MethodsFifteen 12-week old sprague-dowley rats were ovariectomized to develop osteoporosis. After 8 weeks of healing period, two titanium implants were bilaterally placed in the proximal metaphyses of tibia. The animals were randomly divided into a control group and biophysically-stimulated two test groups with five animals in each group. In the first test group, a pulsed electromagnetic field (PEMF) stimulation was administrated at a 0.2 mT 4 h/day, whereas the second group received low-magnitude high-frequency mechanical vibration (MECHVIB) at 50 Hz 14 min/day. Following completion of two week treatment period, all animals were sacrificed. Bone sites including implants were sectioned, removed en bloc and analyzed using a microCT unit. Relative bone volume and bone micro-structural parameters were evaluated for 144 μm wide peri-implant volume of interest (VOI).ResultsMean relative bone volume in the peri-implant VOI around implants PEMF and MECHVIB was significantly higher than of those in control (P < .05). Differences in trabecular-thickness and -separation around implants in all groups were similar (P > .05) while the difference in trabecular-number among test and control groups was significant in all VOIs (P < .05).ConclusionBiophysical stimulation remarkably enhances bone volume around titanium implants placed in osteoporotic rats. Low-magnitude high-frequency MECHVIB is more effective than PEMF on bone healing in terms of relative bone volume.

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“…In particular, PEMF stimulation has been investigated in animal models for the improvement of biomaterial osteointegration [Shimizu et al, 1988;Spadaro et al, 1990;Ijiri et al, 1996;Matsumoto et al, 2000;Ottani et al, 2002;Buzza et al, 2003;Fini et al, 2006]. Almost all these studies have shown that PEMF stimulation can be applied locally and can significantly enhance the osteointegration of titanium alloy, stainless steel and ceramic implants in the skeletal system [Shimizu et al, 1988;Spadaro et al, 1990;Ijiri et al, 1996;Matsumoto et al, 2000;Fini et al, 2002;Ottani et al, 2002;Fini et al, 2006]. Spadaro et al [1990] studied bone response around both stable and unstable intramedullary nails.…”

Section: Discussionmentioning

confidence: 99%

Effects of pulsed electromagnetic stimulation on patients undergoing hip revision prostheses: A randomized prospective double‐blind study

Fini¹,

Giavaresi²,

Piccolo³

et al. 2009

Bioelectromagnetics

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In this prospective, randomized, double-blind study, the effect of Pulsed Electromagnetic Fields (PEMFs) was investigated in 30 subjects undergoing hip revision using the Wagner SL stem. The subjects were treated for 6 h/day up to 90 days after revision. Study end points were assessed clinically by the functional scale of Merle D'Aubigné and instrumentally by Dual-Energy X-ray Absorptiometry (DXA) at the Gruen zones. Subject improvement according to Merle D'Aubigné scale was higher (P < 0.05) in subjects undergoing active stimulation compared to placebo. In analyzing the DXA findings, we subtracted for each area the postoperative bone mineral density (BMD) values from those measured at 90 days and we considered all results above 3.5% as responders. There were no significant differences in the average BMD values at each Gruen zone between the two groups both postoperatively and at 90 days investigation. In Gruen zones 5 and 6, corresponding to the medial cortex, we observed six responders (40%) in both areas in the control group, while in the stimulated group we observed 14 (93%) and 10 (66%) responders, respectively (both P < 0.05). This study showed that PEMF treatment aids clinical recovery and bone stock restoration.

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The Effect of Pulsing Electromagnetic Fields on Bone Ingrowth into a Porous Coated Implant.

Cited by 16 publications

References 3 publications

Comparison of Effects of Pulsed Electromagnetic Field Stimulation on Platelet-Rich Plasma and Bone Marrow Stromal Stem Cell Using Rat Zygomatic Bone Defect Model

Comparison of Effects of Pulsed Electromagnetic Field Stimulation on Platelet-Rich Plasma and Bone Marrow Stromal Stem Cell Using Rat Zygomatic Bone Defect Model

Micro-morphologic changes around biophysically-stimulated titanium implants in ovariectomized rats

Effects of pulsed electromagnetic stimulation on patients undergoing hip revision prostheses: A randomized prospective double‐blind study

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