The effect of pulmonary rehabilitation on COPD exacerbation frequency per year

Şahin, Hülya; Varol, Yelda; Naz, İlknur; Tuksavul, Fevziye; Özsöz, Ayşe

doi:10.1111/crj.12507

Cited by 17 publications

(18 citation statements)

References 37 publications

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“…For this reason, PR is considered to be one of the most efficient nonpharmacological methods in the treatment of COPD patients (24). Changes in pulmonary functions after PR show variation, however, and there are studies reporting no change in pulmonary functions (25,26) as well as the studies reporting increased FEV 1 values after PR (27)(28)(29). In our study, there was a significant increase in FEV 1 values in the normal-weight and pre-obese patients, whereas the increase in obese patients was not significant.…”

Section: Discussionmentioning

confidence: 99%

“…Earlier studies demonstrated increased exercise capacity after PR (27)(28)(29). One study, which evaluated exercise capacity using an incremental shuttle walk test and endurance shuttle walk test by grouping the patients according to BMI found that the baseline ISWT value was significantly lower in obese patients and that there was a significant increase in all groups after PR, but the difference between the groups was not significant (31).…”

Section: Discussionmentioning

confidence: 99%

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Does Increased Body Mass Index Effect the Gains of Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease Patients?

Şahin¹,

Naz²,

Varol³

et al. 2017

Eurasian J Pulmonol

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Obesity is one of the most important public health problems, and it is increasing in prevalence worldwide (1,2). Obesity is an inflammatory disease that involves many systems in the body, especially the respiratory system, causing changes in pulmonary functions (2). Chronic obstructive pulmonary disease (COPD) is also an important public health problem usually accompanied by nutritional abnormalities (3, 4). The majority of COPD patients are overweight or obese rather than normal or low-weight (4). Obesity and COPD cause mortality and morbidity all over the world, and this global outbreak is predicted to be much higher in the future (5). Obesity might be the reason for respiratory symptoms alone due to decreased pulmonary compliance, increased work in breathing, and increased need for oxygen, even without airway obstruction. However, obesity might also increase the numbers of obstructed peripheral airways (6). It was determined that dyspnea perception is enhanced, health status is impaired, and quality of life (QOL) is reduced in obese COPD patients compared to non-obese COPD patients (7,8). It has been shown that pulmonary rehabilitation (PR) reduces dyspnea, enhances exercise performance, improves QOL, and decreases psychological symptoms in COPD patients (9). The present study aimed to compare the gains of PR in obese, pre-obese, and normal-weight COPD patients who completed an 8-week outpatient PR program. AbstractObjective: We aimed to compare the gain of pulmonary rehabilitation (PR) in obese, pre-obese, and normal-weight patients with chronic obstructive pulmonary disease (COPD) who underwent a PR program.Methods: COPD patients (n=137) underwent pulmonary and cardiac system examination and pulmonary function tests (PFTs) before PR. Chest X-rays, arterial blood gases, body mass index, quality of life (QOL) questionnaires, anxiety and depression scores, and Modified Medical Research Council dyspnea scale (MMRC) scores were evaluated in all patients. A 6-min walk test was performed to determine the exercise capacity of the patients. All patients underwent an 8-week outpatient PR program. The patients were reevaluated at the end of 8th week in terms of all parameters. Results:The study group consisted of 44 normal-weight, 52 pre-obese, and 41 obese COPD patients. Before PR, there was no significant difference in terms of 6-min walk distance (6MWD), PFT, MMRC, or QOL scores between the groups (p>0.05 for all). After PR, partial arterial oxygen pressure and arterial saturation, MMRC, and QOL scores improved significantly in all three groups (p<0.05 for all). 6MWD and walkwork significantly increased after PR in all three groups (p<0.001 for all), but the gain in 6MWD was significantly lower in obese patients compared to pre-obese and normal-weight patients (p=0.049). Conclusion:Pre-obese and obese patients benefit from PR similarly to the normal-weight patients in terms of gas exchange, dyspnea perception, and QOL. But it seems to be that exercise capacity improves less in obese COPD patients compared to pre-o...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Does Increased Body Mass Index Effect the Gains of Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease Patients?

Şahin¹,

Naz²,

Varol³

et al. 2017

Eurasian J Pulmonol

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“…Patients with a higher exacerbation risk score benefitted from reduced frequency of exacerbations and hospital admissions (61). In operative lung cancer patients even mild COPD is associated with significantly higher risk of postoperative complications than those with normal lung function (62).…”

Section: Which Patients Benefit From Rehabilitation Programs?mentioning

confidence: 99%

The key questions in rehabilitation in thoracic surgery

Mahendran¹,

Naidu²

2018

J. Thorac. Dis.

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“…This highlights the well-recognized clinical reality that a substantial proportion of patients continue to exacerbate despite optimized medical therapy 12–14. Given the association between acute exacerbations and both short and long-term outcomes,7,15–17 there is an urgent need to advance pharmacotherapies targeting those with continued episodes 11,18,19…”

Section: Introductionmentioning

confidence: 99%

<p>Mepolizumab in the treatment of eosinophilic chronic obstructive pulmonary disease</p>

Mkorombindo¹

2019

COPD

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Despite maximal medical therapy, a subset of patients with chronic obstructive pulmonary disease continue to suffer acute exacerbations. It is also clear that a subset of this population has elevated blood eosinophils. In addition to clearly responding better to inhaled corticosteroids, it is also possible that this subgroup may benefit from biologic treatments targeting eosinophilic inflammation. Mepolizumab, a humanized monoclonal antibody against interleukin-5 (IL-5), may have a therapeutic effect in a subgroup of patients with COPD and eosinophilic airway inflammation. In this review, we discuss the biologic rationale for mepolizumab targeting IL-5 in eosinophilic COPD as well as the results of recently published clinical trials.

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The effect of pulmonary rehabilitation on COPD exacerbation frequency per year

Cited by 17 publications

References 37 publications

Does Increased Body Mass Index Effect the Gains of Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease Patients?

Does Increased Body Mass Index Effect the Gains of Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease Patients?

The key questions in rehabilitation in thoracic surgery

<p>Mepolizumab in the treatment of eosinophilic chronic obstructive pulmonary disease</p>

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