The Effect of Puberty on the Course of Epilepsy

Diamantopoulos, Nicholas; Crumrine, Patricia K.

doi:10.1001/archneur.1986.00520090013008

Cited by 31 publications

(16 citation statements)

References 17 publications

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“…Some authors suggest an increased risk for seizure onset or preexisting epilepsy worsening during perimenarche (Klein and others 2003). However, others found a trend toward fewer seizures around puberty and perimenarche, with a significant improvement in seizure frequency in female patients after menarche (Diamantopoulos and Crumrine 1986). Little is known regarding the effect of puberty and associated changes in estrogen levels on seizures from animal studies.…”

Section: Estrogens and Seizures During Adolescence: Human And Animal mentioning

confidence: 99%

Estrogens and Epilepsy: Why Are We So Excited?

Velı́šková

2007

Neuroscientist

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Estrogens are essential for normal brain function throughout life. The source of estrogens is not only from the periphery, but local production has also been demonstrated in the CNS. Actions of estrogens involve a variety of effects, which include modulation of gene expression, regulation of neurotransmitter release, or direct inter-actions with neurotransmitter receptors. By these effects, estrogens affect neuronal excitability and thus may play an important role in seizure disorders. Although the original clinical as well as animal studies suggest that estrogens have exclusively proconvulsant properties, it has now become clear that estrogens also produce anticonvulsant effects. These opposite effects of estrogens on seizures may depend on treatment duration, latency prior to seizure testing, mode of administration, estrogen dose and hormonal status, estrogenic species, the region/neurotransmitter system involved, seizure type/model used, and sex. Animal data also suggest that estrogens, specifically beta-estradiol, have neuroprotective effects on seizure-induced hippocampal damage. Further studies are necessary to understand the role of estrogens in seizure disorders. Such under-standing is important, especially for women with epilepsy, to make qualified decisions regarding administration of contraceptives and hormonal replacement therapy as well as for the design of new therapeutic strategies for better seizure control and prevention of seizure-induced neuronal damage.

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Section: Estrogens and Seizures During Adolescence: Human And Animal mentioning

confidence: 99%

Estrogens and Epilepsy: Why Are We So Excited?

Velı́šková

2007

Neuroscientist

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“…Eighty-seven percent of participants had the same number of seizures as in prepuberty. In female participants, better seizure control was obtained following menarche with a reduction of PS (Diamantopoulos and Crumrine, 1986). Others have noticed a worsening of symptoms at the time of puberty or menarche (Morrell et al, 1998).…”

Section: Puberty/menarchementioning

confidence: 96%

Comparison of precipitating factors for mania and partial seizures: Indicative of shared pathophysiology?

Bostock

Kirkby

Garry

et al. 2015

Journal of Affective Disorders

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“…At onset of adolescence, in two-thirds of girls, and regardless of epileptic syndrome, the peri-menarche may be marked by an increase or decrease in seizure frequency and menstrual cycles often become accompanied by cyclic variations of seizure frequency (Diamantopoulos and Crumrine, 1986). Finally, the familial, social, and vocational impact of a disease that has started in childhood is important to consider even for adults with so-called benign epilepsies.…”

Section: General Considerations On Outcome For Epilepsies Persisting mentioning

confidence: 99%