The Effect of Psychotropic Drugs on the Development of the Offspring

Liubimov, B I; Smol'nikova, N M; Strekalova, S. N.; Boiko, S. S.

doi:10.1016/b978-0-08-023768-8.50121-3

Cited by 1 publication

(2 citation statements)

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“…1 H (500 MHz) and 13 C NMR (125 MHz) spectroscopy measurements were carried out with a Bruker Avance 500 MHz spectrometer; solvent: CDCl 3 , internal standard: tetramethylsilane (TMS).…”

Section: Generalmentioning

confidence: 99%

“…[7] Interest in the pharmacology of polycyclic cage compounds was further stimulated when a variety of adamantane derivatives with a wide range of pharmacological properties were synthesized. Adamantane is found in different drugs [memantine, [8] remantadine, [9] midantane [10] and adapromine [11] (drugs against flu, tick-borne encephalitis, CNS diseases), gludantan, [12] bemantane [13] and himantan [14] (Parkinson's disease), dimantane (CNS disease) and kemantane [15] (HIV and chronic fatigue syndrome)]. Evidently the polycyclic cage is useful both as a scaffold for sidechain attachment and to improve drug lipophilicity.…”

Section: Introductionmentioning

confidence: 99%

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A Convenient Road to 1‐Chloropentacycloundecanes – A Joint Experimental and Computational Investigation

Sharapa¹,

Gayday²,

Mitlenko³

et al. 2011

Eur J Org Chem

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An efficient synthetic strategy to obtain 1‐chloro‐Cs‐trishomocubane and 1‐chloro‐D3‐trishomocubane is described. 1‐Chloro‐Cs‐trishomocubane is synthesized by a regioselective Diels–Alder reaction, and B3PW91/6‐31G(d,p) calculations offer a plausible explanation of the reaction mechanism. Surprisingly, 1‐chloro‐Cs‐trishomocubane does not undergo an acid‐catalyzed rearrangement to form 1‐chloro‐D3‐trishomocubane and was obtained by chlorosulfation of Cookson's diketone. A possible mechanism of the reaction involving the formation of Cs‐ and D3‐trishomocubane nonclassical cations was proposed on the basis of a mechanistic [B3PW91/6‐31G(d,p) and MP2/cc‐pVDZ] study.

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“…1 H (500 MHz) and 13 C NMR (125 MHz) spectroscopy measurements were carried out with a Bruker Avance 500 MHz spectrometer; solvent: CDCl 3 , internal standard: tetramethylsilane (TMS).…”

Section: Generalmentioning

confidence: 99%