The effect of psychotropic drugs on the occurrence and course of COVID-19

Abstract

fluvoxamine, a selective serotonin reuptake inhibitor (SSRI), while other antidepressant drugs can diminish the risk of intubation or death. SSRI drugs act therapeutically in post-covid depression. Antiviral effects of chlorpromazine and haloperidol were not confirmed in clinical observations. The use of long-acting injectable atypical antipsychotic drugs may decrease the risk of infection. Despite the evidence of antiviral action of lithium -against herpes in clinical studies and against coronaviruses in experimental papers, the current data on the effect of lithium on the occurrence and course of COVID-19 infection do not allow firm conclusions. Also, the data on the use of valproate is equivocal despite propitious theoretical premises. In the article, the potential of other drugs used in psychiatric therapeutics such as amantadine, disulfiram, hydroxyzine, cannabidiol, melatonin, and memantine was discussed. Conclusions. Drugs acting therapeutically on the course of COVID-19 may include fluvoxamine and other antidepressants. A favourable effect of lithium on the occurrence and course of COVID-19 infection has not been unambiguously demonstrated despite previous numerous data on the drug's antiviral activity. StreSzczenieCel. Przedstawienie aktualnych danych eksperymentalnych i klinicznych dotyczących stosowania leków psychotropowych u chorych z infekcją COVID-19. Przegląd piśmiennictwa. Przegląd obejmuje piśmiennictwo z lat 2020-2022 dotyczące wpływu leków Review article / Artykuł poglądowyThe effect of psychotropic drugs on the occurrence and course of COVID-19 Wpływ leków psychotropowych na występowanie i przebieg