The effect of proton pump inhibitors
on the gastric mucosal microenvironment

Peng, Yen‐Chun; Huang, Lan-Ru; Ho, Hui‐Ching; Chang, Cheng-Chen; Lee, Shou-Wu; Cheng, Ching-Chang; Wen, May-Ching; Yeh, Hong‐Zen

doi:10.17219/acem/33116

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…The conventional approaches for H. pylori eradication are proton‐pump inhibitor (PPI)‐containing 7‐day triple regimens that include a PPI and two antibiotics, which can include clarithromycin, metronidazole, or amoxicillin. PPIs are acid‐inhibiting agents and play an important role in H. pylori eradication therapies by enhancing the efficacy of antibiotics . However, in recent years, a decline in the success ratio of PPI‐containing triple regimens has been noted .…”

Section: Introductionmentioning

confidence: 99%

Review: A Japanese population‐based meta‐analysis of vonoprazan versus PPI for Helicobacter pylori eradication therapy: Is superiority an illusion?

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Review: A Japanese population‐based meta‐analysis of vonoprazan versus PPI for Helicobacter pylori eradication therapy: Is superiority an illusion?

et al. 2017

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“…Functional loss of ATP6AP2 induced to be pathognomonic for tumour in granular cells [52]. Although granular cell tumour is rare neoplasm to exhibit nonaggressive behaviour, relation between proton pump and ATP6AP2 may have some responsible for development of gastritis because ATP6AP2 is a subunit of v-H+ ATPase and it is essential for v-H+ ATPase to canonically function as a proton pump through plasma membrane [53]; however, the decrease in the stomach by proton pump inhibitor reduces the infiltration of H. pylori [54]. Furthermore, after H. pylori eradication successfully, long-term proton pump inhibitor users increased the risk of gastric cancer [55].…”

Section: H Pylori Infection and Cancermentioning

confidence: 99%

Quantum microRNA network analysis in gastric and esophageal cancers: Xenotropic plant microRNAs cure from cancerous paradox via Helicobacter pylori infection

Fujii¹

2019

Gastroenterol Hepatol Endosc

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Objective: We have previously shown the aetiology of cancer progression in breast, lung, pancreatic and colorectal cancers by the circulating microRNA (miRNA) panel using the miRNA entangling target sorter (METS) analysis with quantum miRNA language. It has been unveiled by the METS analysis that miRNA/miRNA quantum programming code would control oncogenesis via the hub miRNA in the miRNA biomarker panel. While the etiologic implication between gastric cancer and Helicobacter pylori (H. pylori) is still not cleared, many reports have statistically supported the efficacy of eradication of H. pylori to reduce the risk of gastric cancer. Material and methods:To elucidate etiological significance of the biomarker miRNA panel in H. pylori infection, the data was firstly extracted from database to predict a feasible explanation for H. pylori pathogenicity upon cancer in the stomach. The aetiologies of gastric and oesophageal cancers, and H. pylori infection with or without vegetables and fruits were dynamically simulated by the computation using the quantum miRNA language with the METS. Statistical analysis was also performed by machine learning.Results: In the quantum network, H. pylori infection showed proton pump inhibition, and insulin-like growth factor 1 receptor (IGF1R) expression was reduced as the common factor between gastric cancer stage I and H. pylori infection; however, both were pathogenic but not seriously oncogenic. Statistically, chronic H. pylori infection itself was not be significant upon oncogenic. Conclusions:The environmental stress including mal-diets, such as long-term less fresh vegetable and fruit, would dysregulate miRNA expression, additionally it may contribute most for increasing risk of gastric cancer through enhancing glucose metabolic pathway on a paradox in Zen Buddhism riddle via IGF1R inhibition by H. pylori infection. Thus, xenotropic plant miRNAs (xenomiRNAs) from fresh vegetables and fruits may cure from paradoxical tumorigenesis with H. pylori infection.

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“…The usage of proton pump inhibitors (PPIs) can increase H. pylori ER 6 . The most traditionally used regimen for eradicating H. pylori is a triple regimen that comprises a PPI and two antibiotics, such as clarithromycin, metronidazole, or amoxicillin 7 . Nonetheless, the ER of such triple regimens containing PPIs has decreased recently owing to antibiotic resistance 8 .…”

Section: Introductionmentioning

confidence: 99%

Meta‐analysis of Helicobacter pylori eradication therapy using vonoprazan as an acid suppressor compared with bismuth quadruple therapy

Yang,

Zhang,

et al. 2024

Helicobacter

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BackgroundVonoprazan, a novel acid suppressant, has recently emerged as a regimen for eradicating Helicobacter pylori. However, uncertainties exist about the effectiveness and safety of VPZ‐based regimens compared with those of bismuth‐based quadruple therapy in eradicating H. pylori. The present meta‐analysis was performed to compare the effectiveness and safety of vonoprazan‐based regimens with those of bismuth quadruple therapy in eradicating H. pylori.Materials and MethodsAll randomized controlled trials and non‐randomized controlled trials comparing the vonoprazan‐based therapy with the bismuth quadruple therapy were included in this meta‐analysis. Information was also extracted by two evaluators, and if heterogeneity existed, a random‐effects model was used to calculate the combined relative ratio and 95% confidence interval; otherwise, a fixed‐effects model was used. And subgroup analyses were performed to explore the sources of heterogeneity.ResultsA total of 10 studies, comprising 2587 patients were included in the meta‐analysis. The results showed that the combined eradication rate of patients treated with the vonoprazan‐based regimen was significantly higher than that of patients treated with bismuth quadruple therapy, in both intention‐to‐treat and per‐protocol analyses, and the differences were statistically significant. Among the intention‐to‐treat analyses results: (90.28% vs. 83.64% [odds ratio (OR) = 1.85, 95% confidence interval (CI) (1.27, 2.70), p = 0.001]); in the per‐protocol analyses: (94.80% vs. 89.88%, [OR = 2.25, 95% CI (1.37, 3.69), p = 0.001]). The occurrence of adverse events was significantly lower in patients treated with vonoprazan‐based regimens than in those treated with bismuth quadruple therapy, (14.50% vs. 25.89%, [OR = 0.49, 95% CI (0.32, 0.75), p = 0.001]).ConclusionsFor eradicating H. pylori, vonoprazan‐based regimens are remarkably advantageous over bismuth quadruple therapy. Furthermore, vonoprazan‐based regimens exhibit a lower rate of adverse events than bismuth quadruple therapy.

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The effect of proton pump inhibitors on the gastric mucosal microenvironment

Cited by 4 publications

References 18 publications

Review: A Japanese population‐based meta‐analysis of vonoprazan versus PPI for Helicobacter pylori eradication therapy: Is superiority an illusion?

Review: A Japanese population‐based meta‐analysis of vonoprazan versus PPI for Helicobacter pylori eradication therapy: Is superiority an illusion?

Quantum microRNA network analysis in gastric and esophageal cancers: Xenotropic plant microRNAs cure from cancerous paradox via Helicobacter pylori infection

Meta‐analysis of Helicobacter pylori eradication therapy using vonoprazan as an acid suppressor compared with bismuth quadruple therapy

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