The effect of protein quality and ascorbic acid deficiency on stimulation of hepatic microsomal enzymes in guinea pigs

Chadwick, Robert W.; Peoples, A.; Cranmer, Morris F.

doi:10.1016/0041-008x(73)90222-6

Cited by 21 publications

(3 citation statements)

References 20 publications

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“…for: 2,4,5-TCP, 43 ± 7.4; 2,3,5-TCP, 4 ± 0.5; 2,4,5-TCP, 17 ± 2.2; 2,3,4,6-TTCP, 44 ± 7.5; 2,3,4,5-TTCP, 14 ± 3.6; and PCCOL, 41 ± 11.5. tachlorophenol has been detected as a metabolite in rabbits (Karapally et al, 1971) but not in rats (Chadwick and Freal, 1972a). Furthermore, guinea pigs treated with DDT + lindane excrete measurable amounts of 2,3,5,6-TTCP (Chadwick et al, 1973). Lindane is probably metabolized to mercapturic acid derivatives through chlorobenzenes, since mercapturic acids were excreted when chlorobenzenes were administered to rabbits (Jondorf et al, 1955).…”

Section: Resultsmentioning

confidence: 99%

Metabolism of hexachlorocyclohexane to chlorophenols and effect of isomer pretreatment on lindane metabolism in rat

Freal¹,

Chadwick²

1973

J. Agric. Food Chem.

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Section: Resultsmentioning

confidence: 99%

Metabolism of hexachlorocyclohexane to chlorophenols and effect of isomer pretreatment on lindane metabolism in rat

Freal¹,

Chadwick²

1973

J. Agric. Food Chem.

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“…Guinea pigs treated similarly with DDT or Lindane also displayed enhanced activity of the glucuronic acid pathway, evident as enhanced glucaric acid excretion (FIGURE 3). 11 The data in FIGURE 3 represent groups of female guinea pigs treated in each case but the control with 50 pprn DDT plus 50 ppm Lindane. Enhanced glucaric acid excretion was obtained when the insecticides were administered in a diet containing soy protein or casein, but soy protein supported a much greater response.…”

mentioning

confidence: 99%

ASCORBIC ACID REQUIREMENTS AND METABOLISM IN RELATION TO ORGANOCHLORINE PESTICIDES^*

Street

Chadwick

1975

Annals of the New York Academy of Sciences

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Those organochlorine pesticides which possess both high lipoid solubility and high resistance to biodegradation are prone to accumulation in animal tissues and produce relatively long-term effects as toxicants. Such compounds, typified by DDT, Dieldrin, and Lindane, are profound inducers of hepatic microsomal enzymes, including parts of the glucuronic acid and ascorbic acid biosynthetic pathways. Consequently, administering such pesticides to rats in accompanied by enhanced formation and excretion of D-glucuronic acid and L-ascorbic acid, or D-glucaric acid in the case of guinea pigs. Secondarily, the efficiency in biodegrading the pesticides is reduced in ascorbic-acid-deficient guinea pigs with correspondingly greater residue accumulation in tissue. This would aggravate chronic toxic effects of the compounds. Finally, the capacity of the liver to adapt to the presence of such toxicants through enhanced microsomal enzymatic levels appears to be sensitive to its ascorbate status. Impaired enzyme induction is apparent quite early during ascorbic acid depletion in guinea pigs. The enhanced turnover of ascorbate produced by such pesticides, the poor enzymatic adaptation to them during ascorbate depletion and the dependency of the oxidase system upon adequate ascorbate, all point to the central significance of ascorbate status in the liver, and possibly other tissues, as a determinant of their chronic toxicity.

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“…In addition, a rice diet added with lysine and threonine enhances the liver microsomal MFO activity compared with the diet without those amino acids (33). Furthermore , a diet containing gluten or gelatin is reported to decrease the liver microsomal MFO activity when compared with a diet containing casein at the same level (18,34).…”

Section: Discussionmentioning

confidence: 99%

Liver Microsomal Mixed-Function Oxidases in Response to Dietary Whole Egg Protein Levels in Rats.

Saito

Oh-hashi

Yamaguchi

1992

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryRelation between the activity of liver microsomal mixed function oxidase system and dietary protein level was investigated in rats using purified whole egg protein, i.e. free from limiting amino acids . The animals were given either a diet containing 0, 5, 10, 20 or 40% of protein (experiment 1) or a diet containing 5, 10, 15 or 20% of protein (exper iment 2) for 16 days. In experiment 2, half of the rats of each group were intraperitoneally injected sodium phenobarbital (PB) to induce the mix ed-function oxidase system. The cytochrome P-450 content plateaued even at 5% level of dietary protein in experiment 1 and in the PB -untreated groups of experiment 2. However, it showed the highest value at 15% protein level in the PB-treated groups of experiment 2, indicating a shift of the response peak to a higher protein level due to an increase in protein requirement. Cytochrome P-450 reflected most specifically the dietary protein levels when the enzyme system was induced by PB . The 15% protein level, equivalent to 14.1 protein calories % , is a little higher than the optimal dietary level of whole egg protein ever obtained by usual nutritional indices.

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The effect of protein quality and ascorbic acid deficiency on stimulation of hepatic microsomal enzymes in guinea pigs

Cited by 21 publications

References 20 publications

Metabolism of hexachlorocyclohexane to chlorophenols and effect of isomer pretreatment on lindane metabolism in rat

Metabolism of hexachlorocyclohexane to chlorophenols and effect of isomer pretreatment on lindane metabolism in rat

ASCORBIC ACID REQUIREMENTS AND METABOLISM IN RELATION TO ORGANOCHLORINE PESTICIDES^*

Liver Microsomal Mixed-Function Oxidases in Response to Dietary Whole Egg Protein Levels in Rats.

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The effect of protein quality and ascorbic acid deficiency on stimulation of hepatic microsomal enzymes in guinea pigs

Cited by 21 publications

References 20 publications

Metabolism of hexachlorocyclohexane to chlorophenols and effect of isomer pretreatment on lindane metabolism in rat

Metabolism of hexachlorocyclohexane to chlorophenols and effect of isomer pretreatment on lindane metabolism in rat

ASCORBIC ACID REQUIREMENTS AND METABOLISM IN RELATION TO ORGANOCHLORINE PESTICIDES*

Liver Microsomal Mixed-Function Oxidases in Response to Dietary Whole Egg Protein Levels in Rats.

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Product

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ASCORBIC ACID REQUIREMENTS AND METABOLISM IN RELATION TO ORGANOCHLORINE PESTICIDES^*