The Effect of Prostaglandins on Experimental Tooth Movement in Monkeys (Macaca fuscata)

Yamasaki, Kenichi; Shibata, Y.; Fukuhara, Tatsuo

doi:10.1177/00220345820610121401

Cited by 143 publications

(72 citation statements)

References 7 publications

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“…They found a significant increase in the rate of tooth movement and number of osteoclasts present after local administration of osteocalcin in rats compared to controls that only received administration of phosphate-buffered saline (PBS). Yamasaki et al 48,49 similarly showed an increase in the rate of tooth movement after local administration of prostaglandin E1, a biochemical mediator of bone resorption in both monkeys and humans.…”

Section: Effect Of Bone Remodeling Rates and Density On Tooth Movementmentioning

confidence: 98%

Elevation of a full-thickness mucoperiosteal flap alone accelerates orthodontic tooth movement

Owen¹,

Campbell

Feng

et al. 2017

American Journal of Orthodontics and Dentofacial Orthopedics

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Section: Effect Of Bone Remodeling Rates and Density On Tooth Movementmentioning

confidence: 98%

Elevation of a full-thickness mucoperiosteal flap alone accelerates orthodontic tooth movement

Owen¹,

Campbell

Feng

et al. 2017

American Journal of Orthodontics and Dentofacial Orthopedics

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“…In orthodontics, there seems to be a consensus on the fact that PGE2 injections increase the rate of tooth movement (Bao, Zhao & Rao, 1995;Chao et al, 1988;Kale et al, 2004;Kokkinos et al, 1993;Leiker et al, 1995;Seifi, Eslami & Saffar, 2003). In contrast to orthopedic studies, which typically show anabolic effects of PGE2 (Norrdin, Jee & High, 1990), studies have reported increase in bone resorption alone (Boekenoogen et al, 1996;Chao et al, 1988;Kale et al, 2004;Leiker et al, 1995;Seifi et al, 2003;Yamasaki, Shibata & Fukuhara, 1982). For ERR, there are studies that report an increase (Boekenoogen et al, 1996;Leiker et al, 1995), but there are also studies that report no significant effect of this molecule (Brudvik & Rygh, 1991).…”

Section: Biological Factors In Rate Of Tooth Movement and Errmentioning

confidence: 99%

Orthodontic mechanotransduction and the role of the P2X7 receptor

Viecilli

Katona

Chen

et al. 2009

American Journal of Orthodontics and Dentofacial Orthopedics

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DEDICATIONTo my parents, who have supported my education. iv ACKNOWLEDGMENTSOne of the most important things I have learned during my PhD is the necessity of the existence of a working network of people that can help you achieve your goals. The more effectively this network functions, the higher the chance you will achieve the goals quickly.I would first like to thank my parents, who have unconditionally supported my decision to abandon a profitable private practice in Orthodontics, and return to humble student conditions while aiming for a full time academic career.I also thank my girlfriend Laura Kruter who has (almost always) been ok with my, some might say, not very sane ideas. Sometimes they do turn out fine, though (like this "PhD" one).I can hardly think of anyone else that could have complemented my work and ideas during this Program as well as Dr. Thomas Katona. While I was passionately conditioned to an idea, he was always rational and careful. While I was sometimes furious with a shortcoming, he was always temperate and humorous. When I ran into his office with some news about a project, he would always listen and almost never seem too busy to see me. While I was working and something went wrong, he would listen and wonder with me about the "whys" and "hows", instead of telling me what to do or express disappointment. He was even subject to some of my home culinary experiments. I was extremely fortunate to find someone that thought about science the same way I did, and that actually helped me with my project instead of just telling me what to do. I felt like we worked as a team, and that helped to increase my motivation during my studies. The third part of this project tested the role of the P2X7 receptor in the dentoalveolar morphology of C57B/6 mice. P2X7R KO (knockout) mice were compared to C57B/6 WT to identify differences in a maxillary molar and bone. Tooth dimensions viii were measured and 3D bone morphometry was conducted. No statistically significant differences were found between the two mouse types. P2X7R does not have a major effect on alveolar bone or tooth morphology.The final part examines the role of the P2X7 receptor in a controlled biomechanical model. Orthodontic mechanotransduction was compared in wild-type (WT) and P2X7R knock-out (KO) mice. Using Finite Element Analysis, mouse mechanics were scaled to produce typical human stress levels. Relationships between the biological responses and the calculated stresses were statistically tested and compared.There were direct relationships between certain stress magnitudes and root resorption and bone formation. Hyalinization and root and bone resorption were different in WT and KO. Orthodontic responses are related to the principal stress patterns in the PDL and the P2X7 receptor plays a significant role in their mechanotransduction.

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“…The biomechanical methods involve medicine such as prostaglandin E2, a parathyroid hormone. 1,2 Biostimulation involves the modification of the environment to stimulate existing bacteria capable of bioremediation. With the introduction of therapeutic lasers, biostimulation also refers to the application of photon energy to injured tissue, in order to achieve a stimulatory and regenerative effect at the molecular level.…”

Section: Introductionmentioning

confidence: 99%

Low-Level Laser Effects on Simulated Orthodontic Tension Side Periodontal Ligament Cells

Huang

Liu²,

Chen³

et al. 2013

Photomedicine and Laser Surgery

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Objective: The purpose of this study was to analyze proliferation, inflammation, and osteogenic effects on periodontal ligament (PDL) cells after low-level laser therapy (LLLT) under simulated orthodontic tension conditions. Background data: Low-level lasers affect fibroblast proliferation and collagen synthesis and reduce inflammation. Few studies have focused on the LLLT changes in the PDL caused by moving teeth. Materials and methods: A human PDL cell line was cultured in a -100 kPa tension incubator. The PDL cells were treated with a 670 nm low-level diode laser, output power of 500 mW (continuous wave modus) for 2.5 or 5 sec, spot area 0.25 cm 2 , corresponding to 1.25 and 2.5 J at an energy density of 5 or 10 J/cm 2 , respectively. PDL cell viability was assayed by detecting the ability of the cells to cleave tetrazolium salt to formazan dye. Inflammation and osteogenic markers were analyzed by Western blot analysis. Results: PDL cell viablity increased in the experimental group, based on the ability of the cells to cleave tetrazolium salt at day 7 ( p < 0.05). The experimental group showed no difference in PDL cellular morphology compared with the control group. The inflammation markers inducible NO synthase (iNOS), cyclooxygenase (COX)-2 and interleukin (IL)-1 showed stronger expression in 5 and 10 J/cm 2 therapy at days 1 and 5, but decreased in expression at day 7. The osteogenic marker osteocalcin (OC) expression level was significantly higher at day 7 ( p < 0.05) than in the control cells. Conclusions: LLLT significantly increased PDL cell proliferation, decreased PDL cell inflammation, and increased PDL OC activity under the tension conditions used in this study.

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The Effect of Prostaglandins on Experimental Tooth Movement in Monkeys (Macaca fuscata)

Abstract: Local administrations of prostaglandins E1 or E2 combined with orthodontic tooth movement can approximately double the rate of tooth movement in monkeys compared to that of the control. Macroscopically, no side-effect was observed in the gingiva and associated structures.

Cited by 143 publications

References 7 publications

Elevation of a full-thickness mucoperiosteal flap alone accelerates orthodontic tooth movement

Elevation of a full-thickness mucoperiosteal flap alone accelerates orthodontic tooth movement

Orthodontic mechanotransduction and the role of the P2X7 receptor

Low-Level Laser Effects on Simulated Orthodontic Tension Side Periodontal Ligament Cells

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