The effect of propranolol on luteinising hormone and prolactin plasma concentrations in hypertensive women.

Dart, AJ; McHardy, K C; Barber, HE

doi:10.1111/j.1365-2125.1982.tb02046.x

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…Uusitupa et al (1982a,b) found that propranolol 40 mg three times daily and metoprolol 50 mg three times daily had no effect on plasma cortisol compared with placebo in normal volunteers. Similarly, Dart et al (1982) reported that 2 weeks of ----atenolol 95% CI, ---bopindolol 95% CI. See text for explanation.…”

Section: Discussionmentioning

confidence: 93%

Withdrawal phenomena after atenolol and bopindolol: hormonal changes in normal volunteers.

Walden¹,

Tomlinson²,

Graham³

et al. 1990

Brit J Clinical Pharma

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1. In order to observe and compare the withdrawal phenomena which follow treatment with the beta‐adrenoceptor blocking drugs, bopindolol (with partial agonist activity PAA) and atenolol (without PAA), two groups of six normal volunteers were studied before, during and after 16 days drug administration. 2. Measurements of plasma levels of cortisol, prolactin, insulin, noradrenaline, adrenaline, glucose and potassium were made during a pre‐treatment baseline period, on maximum dose and for 21 days after drug withdrawal. Isoprenaline infusions were given to determine sensitivity of heart rate responses and haemodynamic changes measured in response to physiological manoeuvres. 3. Following atenolol withdrawal the results show hormonal evidence of adrenergic overactivity in the form of elevation of plasma cortisol, insulin and glucose levels. After bopindolol withdrawal there was, in contrast, an overshoot of plasma prolactin and a persistent elevation of plasma potassium and adrenaline post‐isoprenaline. 4. The hormonal changes which follow withdrawal of atenolol and bopindolol are associated with haemodynamic changes reported elsewhere (Walden et al., 1990). 5. These observations provide confirmatory evidence of a post beta‐adrenoceptor blockade withdrawal syndrome which differs between the two drugs studied and this may reflect the properties of the drugs, in particular the PAA of bopindolol.

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Section: Discussionmentioning

confidence: 93%

Withdrawal phenomena after atenolol and bopindolol: hormonal changes in normal volunteers.

Walden¹,

Tomlinson²,

Graham³

et al. 1990

Brit J Clinical Pharma

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“…Within the group of antihypertensives, beta-blockers are most frequently used. There are studies that demonstrate a reduction of PRL levels after the use of propranolol [ 137 ]. Chronic use of propranolol (more than 6 weeks) produces a significant decrease in nocturnal PRL concentrations in healthy controls [ 137 , 138 ].…”

Section: Effect Of Current (Anti-migraine) Treatment On Prolactin Levelsmentioning

confidence: 99%

“…There are studies that demonstrate a reduction of PRL levels after the use of propranolol [ 137 ]. Chronic use of propranolol (more than 6 weeks) produces a significant decrease in nocturnal PRL concentrations in healthy controls [ 137 , 138 ]. Although there is controversy about the mechanism by which propranolol decreases PRL levels, it may be partially due to a central mechanism, or in relation to the antihypertensive effect of the drug.…”

Section: Effect Of Current (Anti-migraine) Treatment On Prolactin Levelsmentioning

confidence: 99%

Prolactin and oxytocin: potential targets for migraine treatment

et al. 2023

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Migraine is a severe neurovascular disorder of which the pathophysiology is not yet fully understood. Besides the role of inflammatory mediators that interact with the trigeminovascular system, cyclic fluctuations in sex steroid hormones are involved in the sex dimorphism of migraine attacks. In addition, the pituitary-derived hormone prolactin and the hypothalamic neuropeptide oxytocin have been reported to play a modulating role in migraine and contribute to its sex-dependent differences. The current narrative review explores the relationship between these two hormones and the pathophysiology of migraine. We describe the physiological role of prolactin and oxytocin, its relationship to migraine and pain, and potential therapies targeting these hormones or their receptors.In summary, oxytocin and prolactin are involved in nociception in opposite ways. Both operate at peripheral and central levels, however, prolactin has a pronociceptive effect, while oxytocin appears to have an antinociceptive effect. Therefore, migraine treatment targeting prolactin should aim to block its effects using prolactin receptor antagonists or monoclonal antibodies specifically acting at migraine-pain related structures. This action should be local in order to avoid a decrease in prolactin levels throughout the body and associated adverse effects. In contrast, treatment targeting oxytocin should enhance its signalling and antinociceptive effects, for example using intranasal administration of oxytocin, or possibly other oxytocin receptor agonists. Interestingly, the prolactin receptor and oxytocin receptor are co-localized with estrogen receptors as well as calcitonin gene-related peptide and its receptor, providing a positive perspective on the possibilities for an adequate pharmacological treatment of these nociceptive pathways. Nevertheless, many questions remain to be answered. More particularly, there is insufficient data on the role of sex hormones in men and the correct dosing according to sex differences, hormonal changes and comorbidities. The above remains a major challenge for future development.

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Reboxetine acutely stimulates cortisol, ACTH, growth hormone and prolactin secretion in healthy male subjects

Schüle

Baghai

Schmidbauer

et al. 2004

Psychoneuroendocrinology

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The effect of propranolol on luteinising hormone and prolactin plasma concentrations in hypertensive women.

Cited by 5 publications

References 3 publications

Withdrawal phenomena after atenolol and bopindolol: hormonal changes in normal volunteers.

Withdrawal phenomena after atenolol and bopindolol: hormonal changes in normal volunteers.

Prolactin and oxytocin: potential targets for migraine treatment

Reboxetine acutely stimulates cortisol, ACTH, growth hormone and prolactin secretion in healthy male subjects

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