The Effect of Prometheus Device on Laboratory Markers of Inflammation and Tissue Regeneration in Acute Liver Failure Management

Efficacy of coupled low-volume plasma exchange with plasma filtration adsorption in treating pigs with acute liver failure: A randomised study

“…Inflammatory cytokines may perpetuate liver damage and extend the inflammatory cascade, thereby compromising other organs [50]. Variations in cytokine levels have been reported in ALF [51,52] and ACLF [53,54] patients after MARS and Prometheus therapy; however, these variations were not significant, probably due to the high rate of cytokine production. The rapid reduction in inflammatory cytokines after the low-volume PE procedure during the Li-ALS treatment played an important role suppressing inflammation, as continuous removal of cytokines by PFA could also help regulate immune function.…”

The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure

“…A beneficial effect of MARS and FPSA on plasma proinflammatory cytokine levels in acute liver failure and on substances such as phenols and dimethylarginine, all of which contribute to the development of HE and brain edema, has been demonstrated [10][11][12]. Whether the effect of these blood purification systems is favorable to brain metabolism has not been studied in patients with ALF.…”

Liver Depurative Techniques: A Single Liver Transplantation Center Experience

“…amino acids [12], and ammonia [9], with conflicting results relating inflammation markers such as tumor necrosis factor-alpha [10,13,14], and interleukin-6 [10,14]. MARS was described in the improvement of hemodynamic parameters such as mean arterial pressure in 2 randomized, controlled studies, although no clinical outcome could be associated [7,15].…”