The Effect of Prolonged Left Ventricular Support on Myocardial Histopathology in Patients with End-stage Cardiomyopathy

Sa, Scheinin; Capek, P; Radovancĕvíc, B; Jm, Duncan; Ha, McAllister; Oh, Frazier

doi:10.1097/00002480-199207000-00035

Cited by 111 publications

(45 citation statements)

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“…1). 22,71 Atrophy, or attenuation, of myofibers without a wavy appearance has been reported in several additional studies in human patients with DCM. 25,32,37,61,62,67,90 Myofiber atrophy is a common response to processes that prevent normal contractile activity and to various pathologic stimuli.…”

Section: Gross Pathology and Histopathologymentioning

confidence: 73%

Histologic Characterization of Canine Dilated Cardiomyopathy

Tidholm¹,

Jönsson

2005

Vet Pathol

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Abstract. Dilated cardiomyopathy (DCM), characterized by chamber dilatation and myocardial systolic and diastolic dysfunction, is one of the most common heart diseases in dogs. The clinical diagnosis is based on findings on echocardiographic and Doppler examinations, with the active exclusion of other acquired or congenital heart diseases. However, the echocardiographic criteria for the diagnosis of DCM are not wholly specific for the disease, and histologic examination may be necessary for final diagnosis. Review of reports on histologic findings in dogs with clinically diagnosed DCM reveals two histologically distinct forms of DCM: 1) cardiomyopathy of Boxers and Doberman Pinschers, corresponding to the ''fatty infiltration-degenerative'' type and 2) the form seen in many giant, large-, and medium-sized breeds, including some Boxers and Doberman Pinschers, classified as the ''attenuated wavy fiber'' type of DCM. The histologic changes of the attenuated wavy fiber type of DCM may precede clinical and echocardiographic signs of heart disease, thus indicating an early stage of DCM.

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Section: Gross Pathology and Histopathologymentioning

confidence: 73%

Histologic Characterization of Canine Dilated Cardiomyopathy

Tidholm¹,

Jönsson

2005

Vet Pathol

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“…Echocardiography reveals decreased left ventricular diameter and an increased ejection fraction [27][28][29]. Among others, we have shown a significant reduction of cardiomyocyte diameters after LVAD).…”

Section: Morphological Changes Of the Myocardium During Chf After Venmentioning

confidence: 95%

Morphological and molecular changes of the myocardium after left ventricular mechanical support

Baba

Wohlschlaeger

2008

Journal of Molecular and Cellular Cardiology

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“…Such recovery was originally observed in the fi rst recipient of a long-term, untethered LVAD, who was supported by the device for 505 days [ 93 , 94 ]. Cardiac recovery was suggested by anatomic, physiologic, and histologic improvements [ 122 ] that were evident upon device removal at transplantation. Other investigators later documented improved function at the cellular and subcellular levels, as characterized by normalization of the deranged calcium transport characteristic of advanced heart failure [ 123 ], a decrease in tumor necrosis factor levels [ 124 -126 ], and improved glucose transport and energy utilization [ 121 , 127 ].…”

Section: Recovery Of Cardiac Function With Long-term Supportmentioning

confidence: 99%

Surgical Treatment of Advanced Heart Failure

Mallidi

Cohn

Frazier

2015

Coronary Artery Disease

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Improved medical therapy is enabling a growing number of patients to survive previously fatal cardiovascular conditions, but many of these patients later succumb to advanced heart failure. Cardiac transplantation is an established surgical treatment option for advanced heart failure, but despite expansion of the criteria for donor selection, the number of hearts available for transplantation remains limited. Mechanical circulatory support with left ventricular assist devices is being used both as a bridge to transplantation and as destination therapy, and it may promote recovery of cardiac function in patients with advanced heart failure. Attempts to develop a transcutaneously powered total artifi cial heart are ongoing. Other treatments under investigation include surgical restoration of the left ventricular wall (Dor procedure) and passive left ventricular reshaping to reverse ventricular dilation, thereby preventing further myocardial cell death, and allowing hypertrophied cardiac cells to resume normal function. Mitral valve repair or replacement for severe secondary mitral regurgitation might also be useful in treating advanced heart failure. In contrast, partial left ventriculectomy is not recommended.

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The Effect of Prolonged Left Ventricular Support on Myocardial Histopathology in Patients with End-stage Cardiomyopathy

Cited by 111 publications

References 0 publications

Histologic Characterization of Canine Dilated Cardiomyopathy

Histologic Characterization of Canine Dilated Cardiomyopathy

Morphological and molecular changes of the myocardium after left ventricular mechanical support

Surgical Treatment of Advanced Heart Failure

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