The effect of prolonged intermittent fasting on autophagy, inflammasome and senescence genes expressions: An exploratory study in healthy young males

Erlangga, Zulrahman; Ghashang, Samaneh Khosandam; Hamdan, Imad; Melk, Anette; Gütenbrunner, Christoph; Nugraha, Boya

doi:10.1016/j.hnm.2023.200189

Cited by 8 publications

(3 citation statements)

References 73 publications

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“…In mice, fasting has been shown to dramatically upregulate neuronal autophagy as evidenced by increased abundance of autophagosome formation and decreased neuronal mTOR activity [ 77 ]. A two-week TRE intervention in healthy humans revealed that serum mRNA expression levels of ULK1 and other proteins involved in autophagy induction were significantly increased and remained elevated for the duration of the restricted feeding schedule [ 78 ].…”

Section: Underlying Mechanisms Of Fasting In Hdmentioning

confidence: 99%

Dietary fasting and time-restricted eating in Huntington’s disease: therapeutic potential and underlying mechanisms

Wells,

Neilson,

McHill

et al. 2024

Transl Neurodegener

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Huntington's disease (HD) is a devastating neurodegenerative disorder caused by aggregation of the mutant huntingtin (mHTT) protein, resulting from a CAG repeat expansion in the huntingtin gene HTT. HD is characterized by a variety of debilitating symptoms including involuntary movements, cognitive impairment, and psychiatric disturbances. Despite considerable efforts, effective disease-modifying treatments for HD remain elusive, necessitating exploration of novel therapeutic approaches, including lifestyle modifications that could delay symptom onset and disease progression. Recent studies suggest that time-restricted eating (TRE), a form of intermittent fasting involving daily caloric intake within a limited time window, may hold promise in the treatment of neurodegenerative diseases, including HD. TRE has been shown to improve mitochondrial function, upregulate autophagy, reduce oxidative stress, regulate the sleep–wake cycle, and enhance cognitive function. In this review, we explore the potential therapeutic role of TRE in HD, focusing on its underlying physiological mechanisms. We discuss how TRE might enhance the clearance of mHTT, recover striatal brain-derived neurotrophic factor levels, improve mitochondrial function and stress-response pathways, and synchronize circadian rhythm activity. Understanding these mechanisms is critical for the development of targeted lifestyle interventions to mitigate HD pathology and improve patient outcomes. While the potential benefits of TRE in HD animal models are encouraging, future comprehensive clinical trials will be necessary to evaluate its safety, feasibility, and efficacy in persons with HD.

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Section: Underlying Mechanisms Of Fasting In Hdmentioning

confidence: 99%

Dietary fasting and time-restricted eating in Huntington’s disease: therapeutic potential and underlying mechanisms

Wells,

Neilson,

McHill

et al. 2024

Transl Neurodegener

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“…39,40 Researchers have also investigated fasting's influence on autophagy, and some studies suggest that intermittent fasting significantly upregulates autophagy. [41][42][43][44] Factors that Link Fasting to Autophagy Fasting is a condition when the cells are starved of nourishment. In such a situation, the intracellular turnover rate of proteins and organelles increases.…”

Section: Potential Effects Of Fasting On the Human Bodymentioning

confidence: 99%

Potential of Medium to Long-Term Fasting to Trigger an Autoimmune Response Through Hyperaggressive Autophagy

Saxena,

Saxena

2023

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Intermittent fasting is a lifestyle intervention that is increasingly gaining traction among the general population. An enhancement in the rate of autophagy is one of the fundamental results of intermittent fasting. Autophagy is a principal intracellular strategy for the maintenance of cellular, somatic, and systemic homeostasis. Gene-based and pharmacological therapeutic modalities which serve to dysregulate autophagy stimulate or exacerbate various diseases in a multiplicity of studies. Consistently, mutations in autophagy-related genetic processes may cause severe human pathologies. We review research and experimental models in order to establish a linkage between autophagy dysfunction to the pathogenesis of some major human disorders, particularly autoimmune disease.

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“…Fasting was shown to reduce markers of inflammation and to counteract the chronic low-grade inflammation (often referred to as "inflammaging") that is strongly correlated with age-associated diseases [7,8]. Fasting was also shown to reduce markers of cellular senescence and thus to possibly help to slow cellular senescence [9]. This partial elimination of senescent cells through fasting is also associated with evidence of tissue regeneration, particularly during the refeeding phase following fasting, often with the involvement of tissue stem cells [10].…”

mentioning

confidence: 99%

Fasting and Cognitive Impairment

Tagliafico,

Nencioni,

Monacelli

2023

Nutrients

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The effect of prolonged intermittent fasting on autophagy, inflammasome and senescence genes expressions: An exploratory study in healthy young males

Cited by 8 publications

References 73 publications

Dietary fasting and time-restricted eating in Huntington’s disease: therapeutic potential and underlying mechanisms

Dietary fasting and time-restricted eating in Huntington’s disease: therapeutic potential and underlying mechanisms

Potential of Medium to Long-Term Fasting to Trigger an Autoimmune Response Through Hyperaggressive Autophagy

Fasting and Cognitive Impairment

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