The effect of proinflammatory cytokines in Cognitive Behavioral Therapy

Moreira, Fernanda Pedrotti; Cardoso, Taiane de Azevedo; Mondin, Thaíse Campos; Souza, Luciano Dias de Mattos; Silva, Ricardo; Jansen, Karen; Oses, Jean Pierre; Wiener, Carolina David

doi:10.1016/j.jneuroim.2015.06.004

Cited by 68 publications

(52 citation statements)

References 26 publications

(34 reference statements)

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“…The findings by Moreira and coworkers in the CBT group, reduced cytokine levels associated with reduced symptom levels , are in accordance with our findings.…”

Section: Discussionsupporting

confidence: 93%

“…A pilot study found that cognitive behavioural therapy (CBT) reduced the depressive symptoms and the mean level of the proinflammatory cytokine interleukin (IL)‐6 in 11 females experiencing their first depressive episode . In a follow‐up study, Moreira et al found that CBT without pharmacotherapy reduced the levels of both IL‐6 and tumor necrosis factor (TNF)α, while Narrative Cognitive Therapy (NCT), less effective in reducing depressive symptoms, did not.…”

Section: Introductionmentioning

confidence: 99%

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Recovery from major depressive disorder episode after non‐pharmacological treatment is associated with normalized cytokine levels

Dahl

Ormstad

Aass

et al. 2016

Acta Psychiatr Scand

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“…The findings by Moreira and coworkers in the CBT group, reduced cytokine levels associated with reduced symptom levels , are in accordance with our findings.…”

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Recovery from major depressive disorder episode after non‐pharmacological treatment is associated with normalized cytokine levels

Dahl

Ormstad

Aass

et al. 2016

Acta Psychiatr Scand

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“…[7][8][9][10] Depression treatments, both pharmacologic and psychotherapeutic, have been shown to work, but are affected by the inflammatory environment and can be improved upon by understanding and addressing the underlying mechanism. [11][12][13][14][15] At the same time, increased awareness of inflammatory mechanisms has led to a paradigmatic shift in the understanding of cancer biology and treatments. One such discovery is the relationship between tumor mutation burden (TMB) or tumor mutation load and immunotherapy response based on the underlying association between creating neoantigens and adaptive immunity response.…”

Section: Introductionmentioning

confidence: 99%

Tumor Mutation Burden and Depression in Lung Cancer: Association With Inflammation

McFarland

Jutagir

Miller

et al. 2020

Journal of the National Comprehensive Cancer Network

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Background: Patients with lung cancer with greater systemic inflammation have higher rates of depression. Tumor mutation burden (TMB) predicts immunotherapy response in patients with lung cancer and is associated with intratumoral inflammation, which may contribute to systemic inflammation and depression. This study evaluated whether higher TMB was associated with increased depression and systemic inflammation in patients with lung cancer. Patients and Methods: Patients with metastatic lung cancers were evaluated for depression severity using the Hospital Anxiety and Depression Scale. TMB was measured using the Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets. Inflammation was evaluated using C-reactive protein (CRP) level and neutrophilto-lymphocyte ratio (NLR). Results: A total of 96 patients with adequate TMB testing were evaluated. The average number of mutations (TMB) was 10.8 (SD, 10.9). A total of 19% of patients endorsed clinically significant depression symptoms. TMB was significantly correlated with depression severity (r 5 0.34; P5.001) and NLR (r 5 0.37; P5.002) but not CRP level (r 5 0.19; P5.07). TMB was also higher in patients receiving chemotherapy (mean, 12.0) and immunotherapy (mean, 14.4) versus targeted therapy (mean, 4.8). A multivariate model found that TMB (b 5 0.30; P5.01) and CRP level (b 5 0.31; P5.01) were independently associated with depression; there was no significant interaction effect of TMB 3 CRP and depression. A similar multivariate model showed no independent effect for NLR and depression (b 5 0.16; P5.17) after accounting for TMB. Conclusions: These data provide evidence for biologic depression risk in patients with lung cancer who have high levels of TMB. The underlying mechanism of the association is not clearly related to inflammation but warrants further analysis to broadly elucidate the mechanism of biologically derived depression in cancer.

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“…The method of treatment by utilizing acupoint points such as acupuncture can improve physical health known through TNF-α expression and is expected to have a positive impact on depression and anxiety disorders [9], [10]. Psychological therapy given can also reduce levels of TNF-α through decreased anxiety [11].…”

Section: Introductionmentioning

confidence: 99%

Acupoint Manipulation in Elderly with Comorbid Disorders

Sudjiwanati¹,

Suparno²

2019

Proceedings of the 6th International Conference on Community Development (ICCD 2019)

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Health problems in the elderly are a natural thing to experience because there is a decline in the function of the organs of the body. Health problems in the elderly can be a serious problem because there are disorders of several diseases that occur simultaneously or known as comorbidity, not only physical disorders but also mental disorders. Therapy given at certain acupoints points is expected to help the elderly in reducing the disorder suffered. The research aimed to determine the effect of acupoint manipulation therapy on the health of elderly with comorbid disorders. The research method used was an experiment with pre and post-test. The number of samples used was 20 elderly with mental-physical comorbid disorders and divided into control groups and treatment groups. The treatment group will be given acupoint manipulation therapy and art therapy. Blood samples will be analyzed in a laboratory to determine the levels of TNF-α in the blood, and mental health conditions obtained from the results of graphical tests. The results showed that the levels of TNF-α and the results of the treatment group psychological test showed no significant results on the control group, but the level of anxiety and TNF-α values in the treatment group was better than the control group. Based on the results of the study it can be concluded that acupoint manipulation therapy has not been able to provide good results, but there is hope that acupoint manipulation therapy can be developed as a complementary treatment method.

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The effect of proinflammatory cytokines in Cognitive Behavioral Therapy

Cited by 68 publications

References 26 publications

Recovery from major depressive disorder episode after non‐pharmacological treatment is associated with normalized cytokine levels

Recovery from major depressive disorder episode after non‐pharmacological treatment is associated with normalized cytokine levels

Tumor Mutation Burden and Depression in Lung Cancer: Association With Inflammation

Acupoint Manipulation in Elderly with Comorbid Disorders

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