The Effect of Probiotics on Reducing Hospitalization Duration in Infants With Hyperbilirubinemia

Torkaman, Mohammad; Mottaghizadeh, Fatemeh; Khosravi, Ardeshir; Najafian, Bita; Amirsalari, Susan; Afsharpaiman, Shahla

doi:10.5812/ijp.5096

Cited by 15 publications

(19 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar observations were made by Raguz et al, Torkaman et al and Khurana et al 8,9,21 However Studies done by Lin et al and Lin et al showed no significant difference in the hospital stay between test and control group. 17,18…”

Section: Duration Of Hospital Staysupporting

confidence: 83%

“…In our study, the mean duration of phototherapy in test and control group was 1.10.3 days and 1.90.9 days respectively which is significant (p=0.01). This view was also echoed by study done by Torkaman et al 9 Demirel et al reported that the administration of probiotics is effective in reducing the duration of phototherapy in very low birth weight (VLBW) newborns of gestational age ≤32 weeks with jaundice. 10 Liu et al reported that therapy with probiotics in term newborns with jaundice lowered the serum bilirubin levels significantly in the treatment group compared to the control group.…”

Section: Duration Of Phototherapymentioning

confidence: 86%

See 1 more Smart Citation

Role of probiotics in clinical course and outcome of preterm neonates

Mohan

Khan

Seshagiri

et al. 2021

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: In a quest to improve the outcome of preterm neonates and to reduce neonatal mortality a lot of research has been done in the field of neonatology; one such intervention is the use of probiotics. We evaluated the role of probiotics in reducing the incidence and severity of NEC, sepsis, hyperbilirubinemia and in improving enteral feeds in preterms.Methods: A prospective randomized control trial was conducted in preterm neonates <37 weeks of gestation from December 2017 to November 2019. They were randomized into test and control groups. The neonates in the test group were fed with probiotics with breast milk twice daily till they reach full feeds. Babies in the control group were fed with breast milk alone. Various parameters were compared between two groups like incidence of NEC, sepsis etc.Results: Sixty preterm neonates were enrolled, 30 in the test group and 30 in the control group. The demographic and clinical variables were similar in both groups. The incidence of NEC and sepsis in the test group is less compared to the control group. Duration of phototherapy was less in test group (1.10.3 days) compared to control group (1.90.9 days). Duration of hospital stay in test group was less (8.92.1 days) compared to the control group (11.43.7 days).Conclusions: Prophylactic probiotics have a beneficial role in prevention of NEC and sepsis, reducing duration of phototherapy and duration of hospital stay in preterm neonates.

show abstract

Section: Duration Of Hospital Staysupporting

confidence: 83%

Section: Duration Of Phototherapymentioning

confidence: 86%

Role of probiotics in clinical course and outcome of preterm neonates

Mohan

Khan

Seshagiri

et al. 2021

Int J Contemp Pediatr

View full text Add to dashboard Cite

show abstract

“…In study done at Torkman et al, and Mehmet mutlu et al, all enrolled newborns were born by NVD. 2,3 In group 1, the mean frequency of stools were 3.76±1.08, 3.72±0.95, 4.02±0.92, 4.03±0.98, 4.09±1.04, 4.01±0.93 and 3.85±1.02 on1 st , 2 nd , 3 rd , 4 th , 5 th , 6 th and 7 th day of life respectively. In group B, the mean frequency of stools were 3.31±1.10, 3.39±0.98, 3.45±0.99, 3.72±0.98, 3.77±1.03, 3.88±0.90 and 3.75±1.00 on 1 st , 2 nd , 3 rd , 4 th , 5 th , 6 th and 7 th day of life respectively as shown in table no 2.…”

Section: Resultsmentioning

confidence: 99%

Effects of probiotics on stool frequency in term newborns

Ashiana

2020

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Probiotics are live micro-organisms, which if given in the right doses, can be beneficial to their host. They are known for their ability to promote the growth of other micro-organisms and to increase the activity of bacteria in the intestinal microflora. Supplementing infants with probiotics was shown to regulate gastrointestinal motility. They can stimulate intestinal peristalsis, which promotes elimination of bilirubin. Probiotics have been shown to increase intestinal transit time.Methods: This study was conducted in Shri Guru Ram Das Institute of Health Sciences and Research involving 150 term healthy newborns. They were divided into two groups. Group 1 was given probiotics with 10ml distilled water and group 2 was given only 10ml distilled water from 1st to 3rd day of life. Total number of stools passed in a day were recorded from 1st to 7th day of life in both the groups.Results: The mean frequency of stools were 3.76±1.08, 3.72±0.95, 4.02±0.92 in group 1 whereas the mean frequency of stools were 3.31±1.10, 3.39±0.98, 3.45±0.99 on 1st, 2nd, 3rd day of life respectively.Conclusions: Statistically significant increase in frequency of stools were observed in group 1(probiotic group) than group 2 (only distilled water group) on 1st to 3rd day of life.

show abstract

“…This evidence supports the use of probiotics as a therapeutic strategy for the prevention of NEC in newborns. 6,7 Furthermore, probiotics have been widely studied in infants; for example, a recent study suggests that probiotics may be beneficial as an adjunct treatment for term infants with hyperbilirubinemia by reducing the duration of hospitalization, 8 and in the prophylaxis and treatment of urinary tract infections in children. 9 The lower prevalence of protective Lactobacillus or Bifidobacterium species in preterm infants compared to term infants makes these species of probiotics a target for the prevention of NEC.…”

Section: Introductionmentioning

confidence: 99%

Single strain versus multispecies probiotic on necrotizing enterocolitis and faecal IgA levels in very low birth weight preterm neonates: A randomized clinical trial

Gómez-Rodríguez

Amador-Licona

Daza-Benítez

et al. 2019

Pediatrics & Neonatology

View full text Add to dashboard Cite

Pediatrics and Neonatology (2019) 60, 564e569 than neonates with a faecal sIgA level increment 0.45 mg/dl. No adverse effects were found after probiotics use. Conclusions: No difference between strains of probiotics used was found on NEC incidence or in the increase of faecal sIgA levels. Faecal sIgA levels were positively related to gestational age and body weight in very low preterm infants. ClinicalTrials.gov/NCT02245815.

show abstract

The Effect of Probiotics on Reducing Hospitalization Duration in Infants With Hyperbilirubinemia

Cited by 15 publications

References 17 publications

Role of probiotics in clinical course and outcome of preterm neonates

Role of probiotics in clinical course and outcome of preterm neonates

Effects of probiotics on stool frequency in term newborns

Single strain versus multispecies probiotic on necrotizing enterocolitis and faecal IgA levels in very low birth weight preterm neonates: A randomized clinical trial

Contact Info

Product

Resources

About