The effect of probiotics on gut flora, level of endotoxin and Child–Pugh score in cirrhotic patients: results of a double-blind randomized study

Lata, Jan; Novotný, Ivo; Příbramská, Veronika; Juránková, Jana; Frič, P; Kroupa, Radek; Stibůrek, Oldřich

doi:10.1097/meg.0b013e3282efa40e

Cited by 123 publications

(91 citation statements)

References 9 publications

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“…Several studies have demonstrated that modulation of the intestinal microbiota in advanced cirrhosis by probiotics or antibiotics is beneficial for the prevention of bacterial translocation and spontaneous bacterial peritonitis [72,73]. It has been shown that antibiotics prevent hepatic injury and fibrosis induced by CCl4 treatment or a cholinedeficient diet, and that LPS enhances hepatic fibrosis induced by a MCCD [74,75].…”

Section: Hepatic Fibrosismentioning

confidence: 99%

The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases

Soares¹,

et al. 2010

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Toll-like receptor 4 (TLR4) is a pattern recognition receptor that functions as lipopolysaccharide (LPS) sensor and whose activation results in the production of several pro-inflammatory, antiviral, and anti-bacterial cytokines. TLR4 is expressed in several cells of healthy liver. Despite the constant confrontation of hepatic TLR4 with gut-derived LPS, the normal liver does not show signs of inflammation due to its low expression of TLR4 and ability to modulate TLR4 signaling. Nevertheless, there is accumulating evidence that altered LPS/TLR4 signaling is a key player in the pathogenesis of many chronic liver diseases (CLD). In this review, we first describe TLR4 structure, ligands, and signaling. Later, we review liver expression of TLR4 and discuss the role of LPS/TLR4 signaling in the pathogenesis of CLD such as alcoholic liver disease, nonalcoholic fatty liver disease, chronic hepatitis C, chronic hepatitis B, primary sclerosing cholangitis, primary biliary cirrhosis, hepatic fibrosis, and hepatocarcinoma.

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Section: Hepatic Fibrosismentioning

confidence: 99%

The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases

Soares¹,

et al. 2010

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“…Reports on possible influencing of bacterial translocation (and thus the development of SBP) using prokinetics [44,45] or probiotics [46] have appeared in the literature.…”

Section: Preventive Treatmentmentioning

confidence: 99%

Spontaneous bacterial peritonitis: A severe complication ofliver cirrhosis

Lata¹,

Stibůrek²,

Kopáčová³

2009

WJG

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“…40 Use of E Coli Nissle strain was reported to result in improvement in liver function, as measured by ChildPugh score, and reduction in endotoxin levels. 41 Those results, however, have not been replicated. These reports indicate the need for large prospective trials to evaluate clinical outcomes of patients with cirrhosis and liver disease treated with probiotics.…”

Section: Other Liver Diseasesmentioning

confidence: 47%

Probiotics and Liver Disease

Sharma

Garg

Aggarwal

2013

TPJ

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The effect of probiotics on gut flora, level of endotoxin and Child–Pugh score in cirrhotic patients: results of a double-blind randomized study

Abstract: E. coli Nissle seems to be effective in the restoration of normal colonic colonization and can probably lower endotoxemia in cirrhotic patients.

Cited by 123 publications

References 9 publications

The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases

The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases

Spontaneous bacterial peritonitis: A severe complication ofliver cirrhosis

Probiotics and Liver Disease

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