The effect of probiotic Lactobacillus casei Shirota on knee osteoarthritis: a randomised double-blind, placebo-controlled clinical trial

Lei, Min; Guo, Chunhua; Wang, D.; Zhang, C.; Hua, Limei

doi:10.3920/bm2016.0207

Cited by 97 publications

(81 citation statements)

References 27 publications

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“…Probiotics and prebiotics, which are safe and effective dietary substances that can be used for elaborating microbial communities 89 , are plausible therapeutic options for obesity-associated OA. A randomized double-blind clinical trial proposed that commercial probiotic L. casei Shirota exhibited beneficial effects on the treatment outcomes of knee joints afflicted with OA 90 . Supplementation with prebiotic fiber in the form of oligofructose could reverse the detrimental effects of fat-enriched diets on gut microbial communities by increasing the abundance of beneficial Bifidobacteria at the expense of numerous proinflammatory microbes, while inducing a considerable and consistent reduction in metabolic inflammation.…”

Section: Therapeuticsmentioning

confidence: 99%

Gut microbiota and obesity-associated osteoarthritis

Liu

Ding

Wang

et al. 2019

Osteoarthritis and Cartilage

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Obesity is a well-known primary risk factor for osteoarthritis (OA). In recent decades, the biomechanicsbased theoretical paradigm for the pathogenesis of obesity-associated OA has been gradually but fundamentally modified. This modification is a result of accumulating evidence that biological factors also contribute to the etiology of the disease. The gut microbiota is a complicated ecosystem that profoundly influences the health of the host and can be modulated by the combined effects of environmental stimuli and genetic factors. Recently, enteric dysbacteriosis has been identified as a causal factor in the initiation and propagation of obesity-associated OA in animal models. Gut microbes and their components, microbe-associated lipid metabolites, and OA interact at both systemic and local levels through mechanisms that involve interplay with the innate immune system. However, the demonstration of causality in humans will require further studies. Nonetheless, probiotics, prebiotics, dietary habits and exercise, which aid the restoration of a healthy microbial community, are potential therapeutic approaches in the treatment of obesity-associated OA.

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Section: Therapeuticsmentioning

confidence: 99%

Gut microbiota and obesity-associated osteoarthritis

Liu

Ding

Wang

et al. 2019

Osteoarthritis and Cartilage

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“…Previous studies have shown several beneficial effects of probiotic supplementation on glycemic control in PCOS patients [ 9 , 10 ]. Moreover, some researchers have demonstrated that probiotic consumption in patients with osteoarthritis [ 11 ], type 2 diabetes mellitus (T2DM) [ 12 ], and gestational diabetes mellitus (GDM) [ 13 ] was associated with decreased inflammatory markers. On the other hand, selenium supplementation has been reported to improve antioxidant parameters in patients with metabolic syndrome [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome

et al. 2018

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BackgroundThe aim of this study was to evaluate the effect of the co-administration of probiotic and selenium on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with PCOS. Data on the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters of patients with polycystic ovary syndrome (PCOS) are scarce. This investigation was carried out to evaluate the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters in women with PCOS.MethodsThis randomized, double-blinded, placebo-controlled clinical trial was conducted on 60 subjects, aged 18–40 years old. Participants were randomly allocated into two groups to intake 8 × 109 CFU/day probiotic plus 200 μg/day selenium supplements (n = 30) or placebo (n = 30) for 12 weeks. Hormonal and inflammatory parameters were measured at baseline and after the 12-week intervention.ResultsProbiotic and selenium co-supplementation resulted in a significant improvement in beck depression inventory (β − 0.76; 95% CI, − 1.26, − 0.26; P = 0.003), general health questionnaire scores (β − 1.15; 95% CI, − 1.97, − 0.32; P = 0.007) and depression anxiety and stress scale scores (β − 1.49; 95% CI, − 2.59, − 0.39; P = 0.009) compared with the placebo. Furthermore, probiotic and selenium co-supplementation significantly reduced total testosterone (β − 0.26 ng/mL; 95% CI, − 0.51, − 0.02; P = 0.03), hirsutism (β − 0.43; 95% CI, − 0.74, − 0.11; P = 0.008), high-sensitivity C-reactive protein (hs-CRP) (β − 0.58 mg/L; 95% CI, − 0.97, − 0.19; P = 0.004) and malondialdehyde (MDA) levels (β − 0.29 μmol/L; 95% CI, − 0.56, − 0.02; P = 0.03), and significantly increased total antioxidant capacity (TAC) (β + 84.76 mmol/L; 95% CI, + 48.08, + 121.44; P < 0.001) and total glutathione (GSH) levels (β + 26.78 μmol/L; 95% CI, + 4.33, + 49.23; P = 0.02) compared with the placebo.ConclusionsOverall, the co-administration of probiotic and selenium for 12 weeks to women with PCOS had beneficial effects on mental health parameters, serum total testosterone, hirsutism, hs-CRP, TAC, GSH and MDA levels.This study was prospectively registered in the Iranian website (www.irct.ir) for registration of clinical trials (http://www.irct.ir: IRCT20170513033941N22).Trial registrationIRCT20170513033941N22.

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“…Recent evidence suggested that inflammation (Lei et al, 2017) and oxidative stress (Chin and Ima-Nirwana, 2018) are involved in the underlying mechanism leading to the cartilage degradation in OA. Not surprisingly, OA…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

Ong¹,

Sakinah²,

Shahril³

et al. 2019

Food Res.

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The increasing number of evidence has reported inflammation and oxidative stress as key mediators of osteoarthritis (OA) joint pathology. Therefore, the usage of dietary supplements targeting inflammation and oxidative stress in OA may emerge as a rewarding therapeutic strategy. This study aimed to explore the efficacy of antioxidant and anti-inflammatory dietary supplements used to manage OA. A methodological framework proposed by Arksey and O’Malley was used to conduct this scoping review. An electronic database search of English academic articles was conducted using PubMed, MEDLINE and ScienceDirect from 2000 to 2018. Randomized controlled trials (RCTs) of OA with parallel groups by comparing dietary supplements with placebo consumption were eligible for inclusion. Out of 69,150 studies identified, a total of 41 studies were included, with 25 antioxidant or anti-inflammatory dietary supplements identified. There were 3325 respondents (1740 in the treatment group and 1585 in the placebo group), all aged ≥ 25 years old and comprised of 69.6% and 30.4% female and male respondents, respectively. The majority of the studies recruited participants with knee OA (n = 33) with a follow-up duration of 3 to 32 weeks. Overall, most of the dietary supplements (n =17) demonstrated a beneficial effect on the clinical signs and symptoms, such as Boswellia serrata extract (BSE), Pycnogenol and L-carnitine. In contrast, Aquamin supplementation did not exert positive impacts on OA management, while inconsistent findings were observed in greenlipped mussel (GLM) extract, vitamin E, methylsulfonylmethane (MSM), licorice flavonoid oil (LFO), ginger, willow bark extract and rose hip supplementation. In summary, the role of anti-inflammatory and antioxidant dietary supplements cannot be ignored as they can offer alleviated pain and symptom relief.

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The effect of probiotic Lactobacillus casei Shirota on knee osteoarthritis: a randomised double-blind, placebo-controlled clinical trial

Cited by 97 publications

References 27 publications

Gut microbiota and obesity-associated osteoarthritis

Gut microbiota and obesity-associated osteoarthritis

The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome

Antioxidant and anti-inflammatory dietary supplements in the treatment of osteoarthritis: a scoping review

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