The Effect of Primary Duodenogastric Bile Reflux on the Presence and Density of Helicobacter pylori and on Gastritis in Childhood

Ağın, Mehmet; Kayar, Yusuf

doi:10.3390/medicina55120775

Cited by 14 publications

(17 citation statements)

References 24 publications

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“…However, Vere et al [15] found biliary reflux more commonly in the elderly (50–80 years) and attributed this finding to a higher incidence of stomach surgery, which is a risk factor for DGR in these patients. In a study by Agin et al [6] on children, DGR was demonstrated to be significantly more common in older children. Likewise, in the present study, the mean age of patients with biliary reflux was found to be significantly higher than that of patients without reflux.…”

Section: Discussionmentioning

confidence: 99%

“…There are a few studies investigating the relationship between DGR and H. pylori in adults, but a paucity of studies involving children. Most of the studies on adults and few studies on children propose that the presence of DGR decreases H. pylori colonization, while the presence of H. pylori increases the prevalence of DGR by impairing antroduodenal motility [1, 2, 6, 8-10]. The aim of the present study was to investigate the relationship between primary DGR and H. pylori prevalence , degree of colonization, and the presence and severity of gastritis in the pediatric population.…”

Section: Introductionmentioning

confidence: 98%

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The Relationship between Primary Duodenogastric Reflux and Helicobacter pylori Gastritis in Children

Arslan¹,

Balamtekin²

2021

Dig Dis

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Background: Most studies of the relationship between duodenogastric reflux (DGR) and Helicobacter pylori have reported that the presence of DGR decreases H. pylori colonization, while H. pylori infection increases the frequency of DGR by impairing antroduodenal motility. The present study aimed to investigate the relationship between primary DGR and the prevalence of H. pylori in children, as well as the degree of colonization and the presence and severity of gastritis. Methods: Included in the study were 410 patients between the ages of 2 and 18 years, referred to the pediatric gastroenterology clinic with complaints of dyspepsia, abdominal pain, and nausea/vomiting, who underwent upper gastrointestinal system endoscopic examination and stomach biopsy. The study group included 60 patients with DGR, while 350 non-DGR patients formed the control group. Results: The mean age of patients with DGR was 15.7 ± 2.1 years, while the mean age of the control group was 14.2 ± 3.8 years (p = 0.02). Of those with DGR, 50 (83.3%) were girls, while in the control group, 215 (61.4%) were girls (p = 0.001). Of patients with DGR, 16 were H. pylori (+) (26.7%), while in the control group, 168 were H. pylori (+) (48%) (p = 0.002). There was no significant difference between the 2 groups with respect to H. pylori degree of colonization (p = 0.08). Gastritis was present in 56 (93.3%) patients in the DGR group and 322 (92%) patients in the control group (p = 0.72). A significant difference was found between the 2 groups in terms of gastritis severity (p = 0.01). Conclusions: The mean age of patients with DGR was significantly higher than that of patients without DGR, and DGR was found to be more common in girls. In patients with DGR, H. pylori prevalence was significantly lower than in those without DGR; however, no significant difference was found between the 2 groups with respect to the colonization degree.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

The Relationship between Primary Duodenogastric Reflux and Helicobacter pylori Gastritis in Children

Arslan¹,

Balamtekin²

2021

Dig Dis

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“…In this case, the presence of bile salts would be responsible for the alkaline pH observed in post-anesthetic evaluations. Although not performed in this study, the resulting analysis of gastric juice with pHmetry would be interesting to demonstrate the presence and concentration of bile salts, diagnosing duodenogastric re ux [31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Changes in Gastric Ph and Gastrine Concentrations in Horses Subjected to Inhalatory General Anesthesia in Dorsal Decubitus

Guerrero¹,

Brito²,

Ferreira³

et al. 2021

Preprint

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Background: In high-performance horses, it is reported that 50 to 90% have stomach disorders, especially gastritis and gastric ulceration, which compromises both, athletic performances, and health status. This work aims to stablish changes in gastric pH and gastrin hormone in horses submitted to general inhalation anesthesia and in supine position, to determine the occurrence of duodenogastric and gastroesophageal reflux. Eight mares fasted for eight hours, subjected to inhaled anesthesia and in supine position were monitored during the anesthetic period. Gastric pH, arterial blood gases and vital signs data were recorded.Results: In the post-anesthetic period, gastric pH was evaluated for 24 h, samples were collected at one-hour intervals. In addition, blood samples were collected for gastrin hormone evaluation before the anesthetic procedure (8-hour fast), during the anesthetic recovery period, and four months after the anesthetic procedure, 90 minutes after the morning meal. Gastric pH during the anesthetic period remained within physiological values (mean value 4.52 ± 1.69), without changes between times (p > 0.05). After anesthesia, mean gastric pH values increased, remaining alkaline during the 24 h of evaluation, differences between T0 (4.88±2.38), T5 (7.08±0.89), T8 (7,43±0,22), T9(7,28±0,36), T11 (7.26±0.71), T13 (6.74±0.90), and T17 (6.94±1.04) (p < 0.05) were observed. There was an increase in gastrin hormone in the post-anesthetic period (20.15±7.65 pg/ml) compared to baseline (15.15±3.82 pg/ml) (p < 0.05). Conclusions: The results obtained demonstrate that general inhalational anesthesia and dorsal decubitus in horses, for 90 min, promotes gastric pH alkalinization for 24hours after anesthesia, possibly induced by entero-gastric reflux. Therefore, gastric mucosa protectors should be considered preventively when horses are submitted to general anesthesia and supine.

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“…The patients with pancreatic diseases included acute or chronic pancreatitis and pancreatic tumors. The selection principle of the 14 potential risk factors above for inducing or deteriorating EPBR mainly hinged on previous literature and our clinical practice experience (14)(15)(16)(17)(18).…”

Section: Clinical Variablesmentioning

confidence: 99%

Analysis of Risk Factors and Establishment of a Prediction Model for Endoscopic Primary Bile Reflux: A Single-Center Retrospective Study

et al. 2021

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Background: Endoscopic primary bile reflux is one of the main diagnostic criteria for bile reflux gastritis (BRG). Presently, the risk factors and prediction models of endoscopic primary bile reflux (EPBR) in gastropathy patients who cannot or will not undergo endoscopy due to contraindications are not clear. Thus, this study aimed to evaluate the risk factors of EPBR and to establish and verify a prediction model.Methods: A series of 844 patients (564 subjects with EPBR and 280 control subjects) were retrospectively selected for this study and divided into a training set (n = 591) and a validation set (n = 253) according to the usual ratio of 70:30% for the subsequent internal validation of the logistic regression model for EPBR. Fifteen parameters that might affect the occurrence of EPBR were collected. Subsequently, univariate and stepwise logistic regression analyses were introduced to reveal the risk factors and the multivariate prediction model. An R package was dedicated to the corresponding internal validation of the EPBR model.Results: The univariate analysis showed that gender, age, smoking, Helicobacter pylori (H. pylori) infection status, metabolic syndrome (MS), non-steroidal anti-inflammatory drugs (NSAIDs) use history, and previous medical histories of chronic liver diseases, cholelithiasis, and erosive gastritis were statistically significant between the two groups (P < 0.05). Multivariate regression described that being a male [OR (95%confidence interval (CI)) = 2.29 (1.50–3.50), P < 0.001], age≥45 years old [OR (95% CI) = 4.24 (2.59–6.96), P < 0.001], H. pylori infection status [OR (95% CI) = 2.34 (1.37–4.01), P = 0.002], MS [OR (95% CI) = 3.14 (1.77–5.54), P < 0.001], NSAIDs use history [OR (95% CI) = 1.87 (1.03–3.40), P = 0.04], cholelithiasis history [OR (95% CI) = 3.95 (2.18–7.18), P < 0.001] and erosive gastritis history [OR (95% CI) = 6.77 (3.73–12.29), P < 0.001] were the risk factors for the occurrence of EPBR. Based on the results of these risk factors, an EPBR prediction model with an adequate calibration and excellent discrimination was established [area under the curve (AUC): 0.839, 95% CI = 0.806–0.872].Conclusions: Being a male, age ≥ 45 years old, H. pylori infection, histories of MS, NSAIDs use, cholelithiasis, and erosive gastritis appear to be the risk factors for EPBR, and our favorable prediction model might be an option for the prediction of EPBR.

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The Effect of Primary Duodenogastric Bile Reflux on the Presence and Density of Helicobacter pylori and on Gastritis in Childhood

Cited by 14 publications

References 24 publications

The Relationship between Primary Duodenogastric Reflux and <b><i>Helicobacter pylori</i></b> Gastritis in Children

The Relationship between Primary Duodenogastric Reflux and <b><i>Helicobacter pylori</i></b> Gastritis in Children

Evaluation of Changes in Gastric Ph and Gastrine Concentrations in Horses Subjected to Inhalatory General Anesthesia in Dorsal Decubitus

Analysis of Risk Factors and Establishment of a Prediction Model for Endoscopic Primary Bile Reflux: A Single-Center Retrospective Study

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