The effect of preventive oral care on treatment outcomes of a cohort of oral cancer patients

Morais, Marília Oliveira; Elias, Marcela Ramos Abrahão; Leles, Cláudio Rodrigues; Pinezi, Juliana Castro Dourado

doi:10.1007/s00520-015-2956-6

Cited by 26 publications

(39 citation statements)

References 35 publications

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“…Poor pre-RT dental hygiene habits have been published in the literature to persist following treatment [15], despite high adherence to oral hygiene methods leading to reduced complications [17,18]. This must be seen as a joint responsibility of the patient and the head and neck oncology team, including the dental practitioner.…”

Section: Oral Hygienementioning

confidence: 99%

Preradiotherapy dental extractions and health-related quality of life

Beech

Porceddu

Batstone

2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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word count: 188 Manuscript word count: 3587 Number of references: 25 Number of tables: 7 AbstractBackground: Health-related quality of life (HRQoL) is a valuable outcome measurement of treatment, particularly in patients undergoing therapy for malignancy. Due to the effects of both disease and treatment, it is important for clinicians to understand the holistic experience of the patient, not just the direct physical effect on morbidity and mortality. Oropharyngeal cancers are often treated with radiation to the head and neck, which presents a number of issues that will affect quality of life, including difficult to manage sequelae such as osteoradionecrosis. Dental extractions performed under any circumstances have an impact on quality of life, and those performed pre and post-radiotherapy are no exception. Aim: The aim of this study was to investigate the connection between preradiotherapy dental extractions and self-reported health related quality of life. Methods: Retrospective data on patients treated with radiotherapy for oropharyngeal cancer were pooled with a cross-sectional survey. Results: greater than 8 pre-radiotherapy dental extractions, p16 negative status, female gender and positive smoking status were associated with statistically significant reduced quality of life. Conclusion: pre-radiotherapy dental extractions do not result in improved quality of life, and may in fact worsen it.

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Section: Oral Hygienementioning

confidence: 99%

Preradiotherapy dental extractions and health-related quality of life

Beech

Porceddu

Batstone

2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…hygiene can also lead the occurrence of OSCC. 5 Nowadays, due to the late stage diagnosis and lack of early diagnostic markers, recurrences, and frequent regional lymph node metastatic, the five-year survival rate is extremely low. 6 Therefore, clinically effective early detection of OSCC biomarkers could significantly improve survival and prognosis.…”

mentioning

confidence: 99%

miR‐454 performs tumor‐promoting effects in oral squamous cell carcinoma via reducing NR3C2

Guo

Wang

et al. 2020

J Oral Pathology Medicine

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Background Aberrant miRNAs expression regulates the occurrence and progression of a variety of cancers, including oral squamous cell carcinoma (OSCC). This study aims to illustrate the potential effects of miR‐454/nuclear receptor subfamily 3 group C member 2 (NR3C2) on the biological behaviors of OSCC cells. Methods GEO database was applied to detect and analyze the expression of miR‐545 and NR3C2 in OSCC tissues. Two OSCC cell lines including CAL27 and Tca‐83 were utilized to determine the function of miR‐454/NR3C2 on OSCC cells biological behaviors. miR‐454 and NR3C2 expressions were regulated by miR‐454 mimic/inhibitor and pcDNA3.1‐NR3C2/si‐NR3C2, respectively. Cells biological behaviors were evaluated by cell proliferation, colony formation, and transwell assays. Results The data collected from GEO database indicated that miR‐454 expression was upregulated in OSCC tissues; however, the expression of NR3C2 assumed a downward trend. In vitro experiments, the expression trend of miR‐454 in OSCC cell lines was consistent with that of the trend in tissues, and the OSCC cells growth and movement abilities significantly decreased after miR‐454 depletion. Through co‐transfection experiments, we explored that the abilities of OSCC cell proliferation, colony formation, invasion, and migration obviously reduced after miR‐454 depletion, but these phenomena were mitigated to some extent after NR3C2 silencing. Conclusion The study illustrates that miR‐454 acts as an active regulator to facilitate OSCC cells growth, colony formation, invasion, and migration by targeting NR3C2, which may afford a novel perspective and possibility for the targeted treatment of OSCC.

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“…The presence of an active dental surgeon in the multidisciplinary team in oncology is therefore indispensable, since this professional can act in the prevention, diagnosis and treatment of oral disorders and in the side effects of antineoplastic therapy [15], leading to an improvement in the systemic conditions and quality of life of hospitalized patients [16]. As can be observed in the described clinical cases 1, 2 and 3.…”

Section: Discussionmentioning

confidence: 89%

Hospital and oncological dental care: a series of cases

Macêdo

Melo

Vidal

2019

RGO, Rev. Gaúch. Odontol.

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ABTRACT Hospital dental care is an educational and health care strategy whose purpose is to intervene, in a multidisciplinary way, in the health-disease process of vulnerable individuals, as unsatisfactory oral health is a risk factor for local and systemic infections. Patients in cancer treatment usually present oral manifestations because of the antineoplastic therapies to which they are submitted. Chemotherapy, radiation and cancer surgery, when the latter held in the head and neck region, have the potential to generate side effects in the oral cavity. These oral manifestations can be serious and interfere with the results of medical therapy, leading to important systemic complications, which can increase hospital stay, treatment costs, and affect the quality of life. In view of this reality, the incorporation of the dentist into the multiprofessional team in oncology is essential to guarantee the patient’s integral care in all stages of therapy. This article then proposes to report a series of cases of patients attended at the Dentistry Service of the Oncology Center of the Oswaldo Cruz University Hospital of the University of Pernambuco, that exemplify the dental surgeon performance in a hospital environment, participating as an active member of a multidisciplinary team in oncology.

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The effect of preventive oral care on treatment outcomes of a cohort of oral cancer patients

Abstract: This study suggests that the implementation of oral preventive measures may contribute to improving the prognosis of squamous cell carcinoma (SCC) treatment by reducing the negative impact of oral complications.

Cited by 26 publications

References 35 publications

Preradiotherapy dental extractions and health-related quality of life

Preradiotherapy dental extractions and health-related quality of life

miR‐454 performs tumor‐promoting effects in oral squamous cell carcinoma via reducing NR3C2

Hospital and oncological dental care: a series of cases

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