The Effect of Preoperative Zintoma Capsule on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

Abstract

BackgroundPostoperative nausea and vomiting (PONV), as one of the complications after laparoscopic cholecystectomy, occurs in over 40% - 77% of cases. Considering the numerous complications of synthetic drugs, there is a growing tendency towards the use of herbal medicines due to their unique features. Ginger root is one of the herbal compounds effective on nausea and vomiting.ObjectivesThe aim of this study was to evaluate the effect of preoperative Zintoma capsules on PONV after laparoscopic cholecystectomy.MethodsIn this quasi-experimental study, 130 eligible patients were randomly assigned to intervention (n = 65) and control (n = 65) groups using the four-block method. The intervention group received two capsules of 500 mg and one of 250 mg Zintoma. The control group received three placebo capsules. The severity of patients’ PONV was recorded at 0, 2, 6, 12, and 24 hours after surgery using a checklist and a standard VAS instrument. Data were analyzed using t-test, Chi-square test, and LSD Post Hoc test (ANOVA) in SPSS 19.ResultsThe severity of PONV and vomiting was significantly different between the two groups (P = 0.001) at the above time points. The mean severity of nausea (by VAS) changed in the intervention group from 7.92 ± 1.28 to 0.33 ± 0.67 and in the control group from 8.00 ± 1.20 to 2.11 ± 1.55. The postoperative vomiting was less frequent in the group receiving the Zintoma capsules. The postoperative use of chemical anti-vomiting and nausea drugs was significantly lower in the intervention group than in the placebo group (P = 0.001).ConclusionsZintoma capsules can be used as a supportive treatment in the prevention of nausea and vomiting by reducing the incidence rate of PONV.

Management strategies for the treatment and prevention of postoperative/postdischarge nausea and vomiting: an updated review

“…Ginger is safe and well tolerated, which appears to be useful in both pregnancy 283 – 285 and chemotherapy-induced PONV 286 , reducing the need for antiemetic rescue medications 287 – 297 . Ginger has also reduced PONV in patients undergoing cholecystectomy 287 – 289 , nephrectomy 282 , 291 , gynecologic/obstetric surgery 293 – 295 , ambulatory surgery 292 , cataract surgery 298 , and thyroidectomy 299 . However, there are also several studies that have reported contradictory results 300 – 302 .…”

Dose Ginger Have Preventative Effects on PONV-Related Eye Surgery? A Clinical Trial

“…Also, ginger significantly reduced the severity of nausea immediately and 2 hours after recovery in patients undergoing eye surgery (P < 0.005). Seidi et al in 2017 (18) and Albooghobeish et al (20) in 2018 demonstrated that the incidence and severity of PONV were significantly lower in the ginger group than in the placebo group. These studies are similar to our study.…”

“…To evaluate nausea, we used a 10 cm linear analog scale that ranged from 0 to 10; scores 0, 1 - 3, 4 - 6, 7 - 9, and 10 were assigned to no, mild, moderate, severe, and very severe nausea, respectively. Vomiting was defined as a severe gastrointestinal stimulation, which caused the forceful discharge of the contents of the digestive tract from the mouth (20). The number of vomiting episodes was recorded (21).…”

“…Nowadays, various strategies including complementary medicine are used to control the condition (15-19). Herbal medicine has been used for thousands of years as a complementary treatment in different countries worldwide (20-22). According to the WHO, more than 80% of the world population is currently using herbal extracts, with more prevalence in undeveloped than in developed countries (23).…”

Günübi̇rli̇k Laparaskopi̇k Kolesi̇stektomi̇de Bakim

“…Yapılan bir çalışmada bülantı-küsmayı o nlemek için ameliyat sonrası tek doz 4 mg Ondansetron HCl verilmiş ve bülantı-küsma yo netiminde etkili oldüg ü bildirilmiştir (10). Literatü rde bülantı küsmanın non-farmakolojik yo netimiyle ilgili birçok çalışma bülünmaktadır (19,34,35). Yapılan bir çalışmada laparoskopik kolesistektomi geçiren bireylere her iki ayag a beşer dakika ayak masajı yapılmış ve bü masajın cerrahi sonrası bülantı küsma ü zerine etkili oldüg ü rapor edilmiştir (19).…”