The effect of preoperative oral administration of prednisolone on postoperative pain in patients with symptomatic irreversible pulpitis: a single‐centre randomized controlled trial

Abstract

Preoperative oral administration of a single dose of 40 mg prednisolone was beneficial to control short-term post-obturation pain after single-visit root canal treatment in patients with symptomatic irreversible pulpitis reducing pain incidence after 24 h by approximately 30% and postoperative analgesic intake by approximately 55%.

Efficacy of corticosteroids for postoperative endodontic pain: A systematic review and meta-analysis

“…Of those 45 references, fourteen were eligible to be included in qualitative analyses [ 14 15 20 21 22 23 24 25 26 27 28 29 30 31 ]. The reasons for exclusion after full-text were that the intervention was a combination of corticosteroid and antibiotic (n = 8), no endodontic treatment (n = 7), no corticosteroid (n = 8), no pain outcome (n = 1), no post- endodontic pain outcome- pain during anesthesia (n = 1) [ 32 ], no control group (n = 1), different intervention (n = 3), no placebo/no treatment group (n = 1) and a review/systematic review of the literature (n = 1).…”

“…The gender and age of the study groups is listed in Table 1 . Eight studies specified their gender ratio of their samples and F/M ratio varied from 0.9 to 2.3 [ 14 15 20 21 23 26 27 31 ] with a majority of females in most of the studies. The age of the participants was between 18 to 71 ( Table 1 ).…”

“…The age of the participants was between 18 to 71 ( Table 1 ). The final number of participants in each study ranged in size from 40 [ 26 ] to 400 [ 14 ].…”

“…Thermal test was the most common diagnostic tool to assess the pulp vitality [ 14 20 22 24 26 ], some of the studies used electrical pulp test (EPT) [ 14 22 24 ]. In some studies, pulp vitality was an important inclusion criteria [ 21 22 25 31 ] but two studies included both vital and non-vital teeth in their intervention group [ 15 26 ].…”

“…The database search was conducted again on 3/1/2018 and two relevant studies were found [ 14 15 ] and a recent systematic review [ 16 ].…”