The Effect of Preoperative Administration of Duloxetine on Postoperative Pain After Laparoscopic Myomectomy

Abstract

The purpose of this study was to evaluate the effect of preoperative administration of duloxetine on postoperative pain after laparoscopic myomectomy. In this double-blind clinical trial study, 57 patients aged 18-55 years with ASA I or II undergoing laparoscopic myomectomy involved. The case group received oral duloxetine 60 mg, and the control group received placebo 2 hours before the surgery. Pain scores, total analgesic consumption during 24 hours, recovery discharging time, nausea, vomiting, dizziness, and hemodynamic changes were recorded and compared between two groups. The pain severity was significantly lower in the case group at 2, 12, and 24 hours after the operation (P<0.05). There were no significant differences in dizziness, nausea, vomiting, systolic and diastolic blood pressure, and heart rate of patients between two groups before the surgery, 5 and 30 minutes after the induction, and after the recovery. Duloxetine administration prior to laparoscopic surgery myomectomy can reduce postoperative pain without inducing side effects in patients.

Virtual reality and its use in post-operative pain following laparoscopy: a feasibility study

“…The trial demonstrated a significant reduction in pain over time. Although there is a paucity of data, the available evidence suggests that in similar populations post-laparoscopy, pain tends to increase in the first two hours following surgery, even with the use of opioid analgesia 24 – 27 . Furthermore, although non-significant, it is of interest that for the entire sample regardless of intervention group that pain scores increased during the washout period (10–20 min).…”

Selective serotonin reuptake inhibitors and serotonin–norepinephrine reuptake inhibitors as adjuncts for postoperative pain management: systematic review and meta-analysis of randomised controlled trials

“…29,30,32e36,38,39,45,48 Most trials (17 of 24; 71%) used general anaesthesia, five (21%) used local or regional anaesthesia, and two studies (8%) allowed the use of either general or regional anaesthesia. 31,36 Background analgesia included acetaminophen alone, 33,40,49,51 or in combination with NSAIDs (celecoxib 36 or metamizole 52 ), opioids (codeine, 30,34 tramadol, 38,42,45,48 fentanyl, 48,50 or oxycodone 45 ), or both, 31,39 and NSAIDs 37,41,43,47 or opioids (morphine or pentazocine) 29 alone. Four trials 32,35,44,46 did not report baseline analgesia.…”

“…Four trials 32,35,44,46 did not report baseline analgesia. Opioids (morphine, fentanyl, 41,45 tramadol, 46 and pethidine 43,51 ) were used as rescue analgesia in 15 trials 30,34,36e38,40,41,43e48,50,51 ; combination of acetaminophen and opioids was used in two trials 33,39 and diclofenac in one trial 42 ; six trials 29,31,32,35,49,52 did not report rescue analgesia.…”

“…Moderate-quality evidence found no significant difference between SSRIs/SNRIs and placebo in PONV (RR 0.95; 95% CI: 0.72e1.25), dizziness (RR 1.33; 95% CI: 0.84e2.10), drowsiness (RR 1.11; 95% CI: 0.46e2.68), headache (RR 1.25; 95% CI 0.63e2.48), and pruritus (RR 0.82; 95% CI: 0.38e1.78) (Supplementary Figs 11e15). In addition, two studies reported no significant difference in adverse events between duloxetine 49 or venlafaxine 30 and placebo, without providing data.…”

Evaluating the Effect of Duloxetine Premedication on Postoperative Analgesic Requirement in Patients Undergoing Laparoscopic Cholecystectomies

“…14 In laparoscopic myomectomy, postoperative pain can be relieved without affecting hemodynamics, sedation, or other side effects in patients who received duloxetine before surgery. 15 However, it has not yet been studied in laparoscopic cholecystectomies. Therefore, this study was designed to evaluate the effect of oral administration of preoperative duloxetine on postoperative pain and total analgesic requirement in the postoperative period in patients undergoing laparoscopic cholecystectomy as the primary objective.…”