The effect of prenatal perfluorinated chemicals exposures on pediatric atopy

Wang, I-Jen; Hsieh, Wu‐Shiun; Chen, Chia-Yang; Fletcher, Tony; Lien, Guang-Wen; Chiang, Hung‐Lung; Chiang, Chow-Feng; Wu, Trong-Neng; Chen, Pau‐Chung

doi:10.1016/j.envres.2011.04.006

Cited by 113 publications

(104 citation statements)

References 38 publications

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“…Five previous birth cohort studies have been conducted examining the adverse effects of prenatal PFAS exposure on clinical infectious or allergic disease (Fei et al 2010;Granum et al 2013;Kishi et al 2013;Okada et al 2012;Wang et al 2011). To our knowledge no previous studies have obtained information about fever as such but only about infectious diseases, as assessed by parental questionnaire or hospital diagnosis, and their findings appear to be somewhat inconsistent (Fei et al 2010;Granum et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Association between prenatal exposure to perfluorinated compounds and symptoms of infections at age 1–4years among 359 children in the Odense Child Cohort

Dalsager

Christensen

Husby

et al. 2016

Environment International

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Introduction: Perfluorinated alkylated substances (PFAS) are persistent industrial chemicals that have resulted in global environmental exposures. Previous epidemiological studies have reported possible effects on the immune system after developmental PFAS exposure, but the possible impact on childhood infectious disease is unclear.Objectives: To investigate the association between prenatal exposure to PFAS and symptoms of infections at age 1-4 years. Methods:The Odense Child Cohort is an on-going prospective study on children's health, where serum concentrations of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorodecanoic acid (PFDA) and perfluorononanoic acid (PFNA) were measured in 649 pregnant women before gestational week 16. Of these women, 359 reported on symptoms of infection in their child every two weeks for a one-year period. The association between prenatal exposure to PFAS and the symptoms was estimated using a logistic regression model and a negative binomial regression model. For the latter, the outcome was reported as an incidence rate-ratio (IRR), and all models were adjusted for maternal age, educational level, parity and child age.Results: On average, and accounting for incomplete reporting, the children experienced symptoms of infection 23% of the time during one year. PFOS exposure in the high tertile compared to the low tertile was associated with a statistically significant increased proportion of days with fever (IRR: 1.65 (95% CI: 1.24, 2.18), p-trend<0.001) and an increased odds of experiencing days with fever above the median (OR: 2.35 (95%CI: 1.31, 4.11). The latter tendency was also apparent for PFOA (OR: 1.97 (95%CI: 1.07, 3.62). Further, higher concentrations of PFOS and PFOA tended to increase the number of episodes of cooccurrence of fever and coughing and fever and nasal discharge during the one-year study period. 4 Conclusion:We found a positive association between prenatal exposure to PFOS and PFOA and the prevalence of fever, which may be a sensitive marker of infection. This finding is in agreement with an immunotoxic effect of prenatal exposure to PFAS. The wider implications for childhood infectious disease deserve attention.

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Section: Discussionmentioning

confidence: 99%

Association between prenatal exposure to perfluorinated compounds and symptoms of infections at age 1–4years among 359 children in the Odense Child Cohort

Dalsager

Christensen

Husby

et al. 2016

Environment International

View full text Add to dashboard Cite

show abstract

“…PFOS, PFOA, PFNA and PFHxS, and indices of foetal growth/development, including birth weight, birth length, ponderal index, gestational age, and pre-term birth, have been conflicting. Some have shown increased levels to be inversely related (Andersen et al, 2010;Apelberg et al, 2007;Fei et al, 2007;Wu et al, 2012;Darrow et al, 2013, Maisonet et al, 2012Wang et al, 2011), whereas others have reported no effect or an opposite association (Fei et al, 2008b, Hamm et al, 2010Olsen et al, 2009).…”

Section: Reproductive and Developmental Toxicitymentioning

confidence: 99%

PFAS in Paper and Board for Food Contact

et al. 2018

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“…A study investigating childhood infection (immunoglobulin E) found no significant correlation between cord blood PFDA and serum total IgE or cord blood IgE in 244 2-year old Taiwanese children (Wang et al, 2011). In summary, there are very few data on the suspected health effects of PFDA and further studies are needed to explore the adverse effects of PFDAs in human.…”

Section:  Immune Systemmentioning

confidence: 99%

“…The authors concluded that their data did not support the hypothesis that prenatal PFOS and PFOA exposures decrease resistance to childhood infections. Wang et al (2011) found that cord blood PFOA was positively associated with cord blood serum IgE in 2-year old Taiwanese boys, whereas Okada et al (2012) found that maternal serum PFOA was negatively associated with cord blood IgE in newborn Japanese girls However, in the latter study no relationship was found between maternal PFOA levels and infant allergies and infectious diseases at age in 18 months (Okada et al, 2012). Recently, another prospective study of birth cohort from the National Hospital in the Faroe Islands (n = 656) reported a negative correlation with antibody response to tetanus and diphtheria booster immunizations at age 5 years with increasing serum PFOA (and PFOS) .…”

Section:  Immune Systemmentioning

confidence: 99%