The Effect of Prenatal Glucose and Insulin Infusion on Carbohydrate Metabolism in the Newborn

Znamenacek, K; Přibylová, H; Sabata, V

doi:10.1111/j.1651-2227.1966.tb15235.x

Cited by 11 publications

(5 citation statements)

References 10 publications

(1 reference statement)

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“…This probably means that FFA are transferred to the fetus only when the FFA level in the mothers is high in connection with starvation or fat assumption. We conclude emphasizing the fact that the FFA retention by the fetus could be affected by means of lipid infusions to the mothers and this procedure, in connection with glucose infusions (14,25), could be considered as a possible approach in the treatment of fetuses with poor intrauterine growth.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Lipid Loading on Fetal Uptake of Free Fatty Acids, Glycerol, and β-Hydroxybutyrate

et al. 1978

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The possibility of influencing the fetal uptake of free fatty acids (FFA), β-hydroxybutyrate (β-OH), and glycerol was demonstrated by enhancing the maternal blood level of these substances by means of 10% intralipid infusions to the mothers during delivery. The FFA uptake, which was not significant in fetuses of control mothers, became positive in fetuses born after maternal infusion with intralipid. The uptake of β-OH and glycerol, which were positive in normal conditions, increased in fetuses from intralipid-infused mothers. These studies demonstrate that, after intralipid infusions to the mothers, the fetal FFA uptake could be correlated with the FFA concentration difference between maternal arterial, and fetal umbilical arterial blood. Since the fetal uptake of FFA subsequent to intralipid infusions is not negligible, we consider the possibility that lipid infusions to the mothers could be an approach to the treatment of the fetus with poor intrauterine growth.

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Section: Discussionmentioning

confidence: 99%

“…It is well known that it is possible to influ ence fetal carbohydrate metabolism by means of glucose infusions to the mothers (14,25). This effect can also be used as a treatment of fetuses with poor intrauterine fetal growth (17).…”

Section: Introductionmentioning

confidence: 99%

Effect of Lipid Loading on Fetal Uptake of Free Fatty Acids, Glycerol, and β-Hydroxybutyrate

et al. 1978

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“…This effect nevertheless depends on the condition of the newborn and on the time of glucose administration. For example, the administration of glucose to mothers had a generally favorable effect and resulted even in blood lactate and excess lactate decreases during the first hours of the newborn's life [9]. A similar effect was achieved on administering glucose to newborns after the delivery.…”

Section: Discussionmentioning

confidence: 65%

“…This is why both obstetricians and pediatricians attempt to provide optimum internal and external environments. Intravenous glucose infusion to the mother during delivery, favorably influencing the metabolism of the newborn proved a suitable inter vention [9], Hypoglycemia can indicate an increased utilization as well as a decreased mobilization of carbohydrate reserves. In the latter case the state is more serious and may result in the newborns in an increased organic acid level in the blood, with a shift to acidosis [10].…”

Section: Discussionmentioning

confidence: 99%

Influence of Glucose Infusion on Oxygen and Carbohydrate Metabolism during Adaptation of the Newborn

Přibylová¹,

Znamenacek²

1970

Neonatology

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“…It is known that fuel availability to the fetus is largely conditioned by maternal levels of energy substrates [36,37,38), prevalently regulated by HPL (Fig. 1).…”

Section: Discussionmentioning

confidence: 99%

Adipose tissue development ?in Utero?

et al. 1980

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Some metabolic and hormonal variables, thought to affect adipose tissue development "in utero" were studied in a group of 50 presumably healthy mothers and in their full-term infants. No sex-related differences were observed at birth in skinfold thickness, body fat mass, fat cell volume or fat cell number. Body fat mass in newborns was significantly correlated to fat cell size (r = 0.75; p < 0.001), but not to fat cell number. Weight gain during pregnancy but not prepregnancy weight was correlated to fat cell volume in the newborn (r = 0.67; p< 0.001) and to body fat mass (r = 0.66; p < 0.001). Maternal placental lactogen levels correlated to decreased glucose tolerance in the mothers (r = 0.62; p < 0.001), as well as to body fat mass (r = 0.61; p < 0.001) and fat cell size (r = 0.58; p < 0.001) in newborns. Neonatal plasma insulin levels in addition correlated with body fat mass (r = 0.39; p < 0.05) and fat cell weight (r = 0.69; p < 0.001) of the neonate. Placental NEFA transfer could be demonstrated, but there was no correlation between maternal plasma NEFA levels and neonatal body fat mass or fat cell weight. Similarly, maternal insulin and growth hormone levels were not correlated with neonatal body fat mass or with fat cell size or number. Thus the nutritional and hormonal factors considered do not appear to be involved in fat cell multiplication. During intrauterine life, in full-term infants of presumably healthy mothers, fat mass expansion seems to occur almost exclusively by means of fat cell hypertrophy.

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The Effect of Prenatal Glucose and Insulin Infusion on Carbohydrate Metabolism in the Newborn

Cited by 11 publications

References 10 publications

Effect of Lipid Loading on Fetal Uptake of Free Fatty Acids, Glycerol, and β-Hydroxybutyrate

Effect of Lipid Loading on Fetal Uptake of Free Fatty Acids, Glycerol, and β-Hydroxybutyrate

Influence of Glucose Infusion on Oxygen and Carbohydrate Metabolism during Adaptation of the Newborn

Adipose tissue development ?in Utero?

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