The effect of prenatal exposure to phthalates on food allergy and early eczema in inner-city children

Stelmach, Iwona; Majak, Paweł; Jerzyńska, Joanna; Podlecka, Daniela; Stelmach, Włodzimierz; Polańska, Kinga; Ligocka, Danuta; Hanke, Wojciech

doi:10.2500/aap.2015.36.3867

Cited by 39 publications

(37 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phthalates have short biological half-lives from hours to a few days, but because exposure is ubiquitous, exposure levels may be relatively constant [5,6]. We identified 14 prospective cohort studies [5,[7][8][9][10][11][12][13][14][15][16][17][18][19] examining the association between prenatal phthalate exposure and asthma or allergy. Findings are inconsistent probably because different metabolites have been measured and the age of the children varied.…”

Section: Introductionmentioning

confidence: 99%

Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study

et al. 2020

View full text Add to dashboard Cite

Background: Prenatal phthalate exposure has been suggested to alter immune responses and increase the risk of asthma, eczema and rhinitis. However, few studies have examined the effects in prospective cohorts and only one examined rhinitis. We therefore studied associations between maternal urinary concentrations of phthalate metabolites and asthma, eczema and rhinitis in offspring aged 5 years. Methods: From 552 pregnant women in the Odense Child Cohort, we quantified urinary concentrations of 12 phthalate metabolites in third trimester. We assessed asthma, rhinitis and eczema in their offspring at age 5 years with a questionnaire based on the International Study of Asthma and Allergies in Childhood (ISAAC), and conducted logistic regression adjusting for relevant confounders. Results: 7.4% of the children had asthma, 11.7% eczema and 9.2% rhinitis. Phthalate exposure was low compared to previous cohorts. No significant associations between prenatal phthalate exposure and asthma were found. Odds ratios (ORs) of child rhinitis with a doubling in ΣDiNP m and di-2-ethylhexyl phthalate metabolite (ΣDEHP m) concentrations were, respectively, 1.15 (95% confidence interval (CI) 0.97,1.36) and 1.21 (CI 0.93,1.58). The OR of eczema when doubling ΣDiNP m was 1.24 (CI 1.00,1.55), whereas the OR of using medicine against eczema when doubling a di-ethyl phthalate (DEP) metabolite was 0.81 (CI 0.68,0.96). Conclusion: The lack of association between maternal phthalate exposure and asthma in the offspring may be due to low exposure and difficulties in determining asthma in 5-year-olds. The higher odds of rhinitis may raise public concern but further research in larger cohorts of older children is warranted.

show abstract

Section: Introductionmentioning

confidence: 99%

Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It is possible that either maternal non‐atopic genetic risk factors either contribute more to AD development risk or in utero insults in mothers with autoimmune disease contribute to the associations we have found. In utero exposure to immunologically active chemicals and immune dysregulation can increase AD development risk …”

Section: Discussionmentioning

confidence: 99%

“…In utero exposure to immunologically active chemicals and immune dysregulation can increase AD development risk. [67][68][69]…”

Section: Discussionmentioning

confidence: 99%

Association between parental autoimmune disease and atopic dermatitis in their offspring: a matched case–control study

Hamann

Egeberg

Silverberg

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

Background Atopic dermatitis (AD) is associated with many autoimmune diseases, in part due to overlapping genetic risk loci. While parental atopic disease is an important risk for AD in the offspring, little is known on the putative associations between parental autoimmune disease and AD in their children. Materials and methods All children born between 1996 and 2011 who received a diagnosis of AD in the hospital system before their fifth birthday were matched 1 : 10 with children from the general population. Maternal and paternal autoimmune diseases were assessed using registry‐based data. Conditional logistic regression was performed on the relationships between parental autoimmune diseases and AD in their children. Results A total of 8589 children with AD were matched with controls. One or more autoimmune disease was identified in 5.89% (506/8589) of mothers to AD children and 3.67% (315/8589) of fathers to AD children compared to 4.85% (4163/85 890) and 3.28% (2816/85 890) in parents of control children. Maternal autoimmune disease but not paternal autoimmune disease was associated with AD in the offspring (odds ratio [OR] 1.20 [95% confidence interval (CI) 1.20–1.32] and OR 1.08 [0.96–1.22], respectively), Two or more maternal autoimmune diseases, maternal dermatologic autoimmune disease and maternal digestive autoimmune disease were all also associated with AD development in her children (1.96 [95% CI 1.36–2.84], OR 1.60 [95% CI 1.24–2.07] and OR 1.24 [95% CI 1.06–1.45], respectively). Conclusions The risk of AD is influenced by many factors including atopy status and filaggrin gene mutations. In this matched case–control study, maternal autoimmune disease was associated with AD diagnosis in the offspring. Maternal dermatologic and digestive autoimmune diseases were most closely associated with subsequent AD diagnosis in the offspring.

show abstract

“…The cord blood 25-hydroxyvitamin D (25(OH)D) levels were inversely associated with the risk of multi-triggered wheezing and, especially, viral-induced wheezing, whereas phthalate exposure increased the risk of food allergy by the age of 2 years old [18,19]. It is crucial to evaluate whether the above associations still persist in the early school age or are compensated by other factors.…”

Section: What Has Been Found Based On Repro _ Pl?mentioning

confidence: 99%

Polish Mother and Child Cohort Study (REPRO_PL) – Methodology of the follow-up of the children at the age of 7

Polańska¹,

Hanke²,

Król³

et al. 2016

Int J Occup Med Environ Health

Self Cite

View full text Add to dashboard Cite

Effects of environmental exposures in utero and in the first years of life on early life health and development is a growing research area with major public health implications. The main aim of this work has been to provide an overview of the next step of the Polish Mother and Child Cohort Study (REPRO _ PL) covering exposure, health and neurodevelopment assessments of children at 7 years of age. Details regarding methodology of the follow-up of the children are crucial for cross-cohort collaboration and a full understanding of the future research questions. Phase III of the REPRO _ PL cohort covers a follow-up of 900 children at the age of 7 years old. The questionnaire filled in by the mothers is composed of: socio-demographic, child exposure and home environment information, nutritional status and health data. In the case of 400 children, environmental (including collection of urine, saliva and buccal cells), health status and psychomotor assessments are performed. Health and development check consists of physical measurements, child health status assessment (including lung function tests, skin prick testing, an interview/examination by an allergist) and psychomotor development tests (the Strength and Difficulties Questionnaire and the Intelligence and Development Scales). The results of the study will become available within the next few years. Extension of the REPRO _ PL cohort with examinations of children at the age of 7 years old may provide a better understanding of the relationship between environmental and lifestyle-related factors and children's health and neurodevelopment; and may further strengthen scientific base for policies and interventions promoting healthy lifestyle. mother-child cohorts [6,7]), in 2 publications focused on REPRO _ PL [8,9] and 2 concerning European birth cohorts [3,4]. In addition to the analyses performed only within the REPRO _ PL sample, the data from this study was also included in combined analyses from a few European cohorts [10][11][12]. To utilize the already performed work it is crucial to follow up the children to address new hypotheses or to evaluate whether the observed associations still persist in the school age. The main aim of this work has been to provide an overview of the next step of the REPRO _ PL study covering the exposure and health as well as the assessment of neurodevelopment among 7-year-old children. The details regarding methodology of the follow-up of the children are crucial for a cross-cohort collaboration and a full understanding of the future research questions. OBJECTIVESREPRO _ PL aims at evaluation of the impact of exposure to environmental and lifestyle-related factors during pregnancy and after birth on pregnancy outcomes and children's health. As regards the children's health and development within the 7 years of life, the study's 3 specific aims refer to: -assessment of the impact of prenatal exposure to maternal lifestyle-related factors (tobacco constituents, alcohol consumption, pre-pregnancy body mass index (BMI), physical...

show abstract

The effect of prenatal exposure to phthalates on food allergy and early eczema in inner-city children

Abstract: Results of our study indicated awareness of environmental factors that may affect children's health because the phthalates were shown to be risk factors for food allergy in children.

Cited by 39 publications

References 0 publications

Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study

Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study

Association between parental autoimmune disease and atopic dermatitis in their offspring: a matched case–control study

Polish Mother and Child Cohort Study (REPRO_PL) – Methodology of the follow-up of the children at the age of 7

Contact Info

Product

Resources

About