The effect of preimplantation genetic screening on the probability of live birth in young women with recurrent implantation failure; a nonrandomized parallel group trial

Sequential embryo scoring as a predictor of aneuploidy in poor-prognosis patients

“…However the current data is a unique retrospective analysis in that it compares the outcomes of PGS patients that elected or qualified for a PGS option, but did not proceed with it, to outcomes when the same group did proceed with PGS. Therefore, the patient groups are well matched making this study comparable with randomized controlled trials (Blockeel et al, 2008;Debrock et al, 2010;Hardarson et al, 2008;Jansen et al, 2008;Mastenbroek et al, 2007;Staessen et al, 2004;Yakin et al, 2008). In addition, the morphological characteristics of all biopsied embryos were related with the PGS results in order to support these findings of improved or similar outcomes using SES to select embryos without PGS.…”

“…Improved success is based on the assumption that high rates of chromosomal abnormalities in the embryos of these patients account for their lack of a successful pregnancy. Despite reports of improved outcomes (Gianaroli et al, 1997(Gianaroli et al, , 1999(Gianaroli et al, , 2003a(Gianaroli et al, ,b, 2005Kahraman et al, 2004;Kuliev and Verlinsky, 2008;Munné et al, 1999Munné et al, , 2003Pehlivan et al, 2003;Verlinsky et al, 2005), prospective, controlled, randomized studies have not found PGS to significantly improve the chance of having a baby (Blockeel et al, 2008;Debrock et al, 2010;Hardarson et al, 2008;Jansen et al, 2008;Mastenbroek et al, 2007;Staessen et al, 2004;Yakin et al, 2008).…”

La controverse de Mastenbroek ou comment le dépistage génétique préimplantatoire fait couler beaucoup d’encre

“…Depuis, cette controverse a généré la publication de très nombreux commentaires [31][32][33][34] et de quelques études, soit en faveur du PGS [35], soit en sa défaveur [36,37]. Seules des études contrôlées randomisées bien conduites et de grande ampleur paraissent alors pouvoir apporter une conclusion sur l'intérêt et les indications réelles du PGS.…”

Assessment and treatment of repeated implantation failure (RIF)

“…Thus, preimplantation genetic screening (PGS), in the presence of normal karyotype, has been suggested for these patients. However, though primary reports were encouraging, subsequent large controlled studies not only did not confirm the advantage of PGS for RIF patients, but also reported lower clinical pregnancy rates, compared to controls [113,120]. Thus, a recommendation of PGS for cleaved embryos is currently not justified for patients with RIF with normal karyotype.…”