The effect of pregnancy on gastric secretion

Labate, John S.

doi:10.1016/s0002-9378(39)90364-9

Cited by 10 publications

(2 citation statements)

References 7 publications

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“…This was disputed by Strauss and Castle (1932) and Way (1945), because they found bile in only very few of their specimens of gastric juice. While most reports have described hypochlorhydria in pregnancy Labate (1939), working in New York, studied 56 women, nine-tenths of whom were in the last trimester and found that if alcohol was used to stimulate secretion a normal acidity was found in three-quarters of them. Sixteen per cent showed complete posthistamine achlorhydria.…”

Section: Review Of Literaturementioning

confidence: 99%

Gastric Secretion in Pregnancy

Murray

Erskine²,

Fielding³

1957

BJOG

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Section: Review Of Literaturementioning

confidence: 99%

Gastric Secretion in Pregnancy

Murray

Erskine²,

Fielding³

1957

BJOG

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“…This has naturally focused attention on gastric secretory activ,ity during this period, and there have been reports of diminished secretion of pepsin and hydrochloric acid during pregnancy (Artz, 1930;Strauss and Castle, 1932; Labate, 1939;Way, 1945;Murray, Erskine, and Fielding, 1957;Hunt and Murray, 1958). In the dog no consistent change in acid gastric secretion was found during pregnancy (McCarthy, Evans, and Dragstedt, 1954;Clark, 1957) while pregnant rats showed a significant reduction (Lozzio, Gagliardi, Biempica, and Royer, 1961).…”

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confidence: 99%

Sex hormones and acid gastric secretion induced with carbachol, histamine, and gastrin

Amure¹,

Omole²

1970

Gut

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SUMMARY This study confirms previous reports that satisfactory gastric acid secretory responses to intravenous administration of histamine, carbachol, and gastrin can be obtained.Bilateral castration of the male rats significantly reduced acid gastric secretory responses to carbachol but not to histamine.Ovariectomized rats treated with 1 7B-oestradiol (short-term treatment) showed a statistically significant reduction in gastric acid secretion induced with all the secretagogues, but the results when rats were treated with testosterone were inconsistent. In animals given gastrin or histamine gastric acid secretion was reduced and was of statistical significance with gastrin (0.02 < p < 0(05) but not with histamine (0.05 < p > 0.1).It is concluded that a high oestrogen blood level is capable of inhibiting effectively acid gastric secretion in both sexes except that a higher level of blood oestrogen is required in the male. Tite results showed further that of all the sex hormones used, only oestrogen had a significant effect on gastric acid secretion.It has long been recognized that peptic ulceration rarely occurs in human pregnancy. This has naturally focused attention on gastric secretory activ,ity during this period, and there have been reports of diminished secretion of pepsin and hydrochloric acid during pregnancy (

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Gastroenterology

Jones¹

1941

Arch Intern Med (Chic)

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The effect of pregnancy on gastric secretion

Cited by 10 publications

References 7 publications

Gastric Secretion in Pregnancy

Gastric Secretion in Pregnancy

Sex hormones and acid gastric secretion induced with carbachol, histamine, and gastrin

Gastroenterology

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