This investigation aims to examine the antimicrobial properties of a few types of medicinal plants on fungi transmitted by leather. In the soxhlet method, the antifungal agents were successfully extracted from the leaves of Azadirachta indica, Lantana camara, Wedelia chinensis, Moringa oleifera and Coccinia grandis using methanolic solvent. The fungus isolates from leather bags, shoes and wallets were cultured in Potato Dextrose Agar (PDA) plates. The two leather-borne fungi Aspergillus sp. and Penicillium sp. were the targets of the antifungal assay. Here plant extracts were applied in concentrations of 5.0%, 10.0% and 15.0%. Azadirachta indica, Moringa oleifera and Lantana camara extract were the most successful treatments for inhibiting the controlled growth of the fungi under this investigation. Furthermore, it is stated that the pathogenic fungi's capacity to proliferate increases with the concentration of plant extracts in the culture. This two-plant showed promising results in treating two cases of fungus, suggesting that it may be used to treat fungi carried by leather.