The effect of pre-eclampsia on complete blood count, platelet count and mean platelet volume

Ceyhan, Temel; Beyan, Cenǵiz; Başer, İskender; Kaptan, Kürşat; Güngör, Sadettin; İfran, Ahmet

doi:10.1007/s00277-006-0091-7

Cited by 81 publications

(66 citation statements)

References 13 publications

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“…Ceyhan et al reported comparable platelet counts and MPV among 56 preeclamptic, 8 severe pre-eclamptic, and 43 control subjects. However, in that study sample size was small and NLR was not investigated (14) .…”

Section: Discussionmentioning

confidence: 99%

Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity

Akıl¹

2015

Kosuyolu Heart Journal

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Introduction: This study was undertaken to examine the role of hematological parameters in predicting the severity of hypertension in pre-eclamptic women. Patients and Methods:Two hundred sixty-one pre-eclamptic women and fi fty-one women with normal pregnancy were included in the study. The severity of preeclampsia was classifi ed as mild or severe.Results: Compared to post-delivery period, pre-eclamptic females had lower platelet count, raised mean platelet volume and raised neutrophil lymphocyte ratio (p< 0.001, p< 0.001, p< 0.001, respectively). Multiple linear regression analysis showed an independent correlation between the severity of hypertension and mean platelet volume as well as the neutrophil lymphocyte ratio (β= 0.25, p< 0.001; β= 0.31, p< 0.001, respectively). Conclusion:Both mean platelet volume and neutrophil lymphocyte ratio emerged as independent predictors of the severity of hypertension in preeclampsia.

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Section: Discussionmentioning

confidence: 99%

Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity

Akıl¹

2015

Kosuyolu Heart Journal

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“…Increased MPV occurs before onset of PE symptoms. Therefore, it may be a valuable marker for development of PE [13]- [15]. Furthermore, it has been suggested that PDW can be a practical tool to evaluate activation of coagulation or thrombocytosis-related disease [16].…”

Section: Introductionmentioning

confidence: 99%

Changes in Platelet Indices during Pregnancy as Potential Markers for Prediction of Preeclampsia Development

Nooh¹,

Abdeldayem²

2015

OJOG

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Objective: To assess whether changes in platelet indices, detectable by simple complete blood count (CBC), during pregnancy could be used as markers for prediction of development of preeclampsia (PE). Methods: A total of 2813 pregnant women who received regular antenatal care until delivery were included. Participants were divided into 3 groups: normotensive pregnant women (n = 2621), women with PE without severe features (n = 169), and women with PE with severe features (n = 23). Blood samples were collected during antenatal visits and/or during the period of in-patient hospital stay, and changes in platelet indices were compared among the three groups. Results: Platelet count (PC) was decreasing while mean platelet volume (MPV) and platelet distribution width (PDW) were increasing as PE progressed. Receiver operating characteristics (ROC) curve analysis showed that PDW had the largest area under curve (AUC) [0.980 (95% CI: 0.964 -1.000)], making it the best marker for predicting development of PE. Also, PDW showed the most statistically significant correlation with mean arterial pressure (MAP) (r = 0.902, p = 0.000), making it the best marker for predicting severity of hypertension. Conclusion: This study provides evidence that PC decreases while MPV and PDW increase as pregnancy advances, and these changes are more pronounced in PE than normotensive pregnancy. These changes predate development of PE by 2 -8 weeks and are proportional to the progress of this disorder. The selected platelet indices, especially PDW, have the potential to be utilized as markers for not only prediction of PE development but also severity of hypertension.

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“…Some conflicting finding has been published regarding the changes in the platelet indices in well pregnant women. Some researchers found no change in the values of these indices between patients and controls (Ceyhan, 2006, Freitas, 2013. Whereas others demonstrated difference in platelet index values (Yong, 2014;Dundar, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Whereas others demonstrated difference in platelet index values (Yong, 2014;Dundar, 2008). This consistency of those studies may be due to the varying methods of platelet indices determination (Ceyhan, 2006). P-LCR was significantly increased in patients with thrombocytopenia and decreased in thrombocytosis condition.…”

Section: Discussionmentioning

confidence: 99%

Platelet Indices among Sudanese Pregnant Women with Medical Disorders Association; A Cross-sectional Study in Port Sudan City

Mohammed¹,

Dirar²,

Badaneen³

2017

ijSciences

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Abstract:Pregnant women with medical disorders may associated with multiple changes in platelet indices parameters. It may be arising from hemodilution or increased platelet consumption during uteroplacental circulation. Platelet indices (PI) are a group of derived platelet parameters extracted as a part of the automatic complete hemogram. This study aimed to investigate the potential role of Platelets as a diagnostic or prognostic marker across the disease associated with Sudanese pregnancies. A cross-sectional study was conducted in March 2015 at Port Sudan Teaching Hospital, Port Sudan, Sudan. 40 Sudanese pregnant women with different medical complications were enrolled and 10 well pregnant women were included in this study. In both, platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), platelet large cell ratio (P-LCR) and platelet cell concentration (P-LCC) were done. The pregnant women with medical association in compared with well pregnant women were found to be significant in the MPV, PDW, P-LCR, and P-LCC (P < 0.022, 0.036, 0.021 and 0.040 respectively). In contrast, PLT and PCT were found to be insignificant (P< 0.871 and 0.666). However, platelet indices were higher in patients than in controls except for the PLT and PCT level no changes were displayed. Accordingly, the convincing laboratory evidences in this study show that the usefulness of platelet indices as marker for medical disorders associated with pregnancy. The MPV and PDW are potential markers in the predicting disease severity.

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The effect of pre-eclampsia on complete blood count, platelet count and mean platelet volume

Cited by 81 publications

References 13 publications

Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity

Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity

Changes in Platelet Indices during Pregnancy as Potential Markers for Prediction of Preeclampsia Development

Platelet Indices among Sudanese Pregnant Women with Medical Disorders Association; A Cross-sectional Study in Port Sudan City

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