The Effect of Potassium, Calcium and Magnesium Concentration on Insulin and Glucagon Secretion of the Perfused Dog Pancreas

Panzig, E; Besch, W; Rosenbaum, K D; Tietz, W; Kiene, S; Wolf, E; Paul, W. D.

doi:10.1055/s-0029-1210473

Cited by 5 publications

(5 citation statements)

References 7 publications

(9 reference statements)

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“…Calcitonin, in one's turn, inhibits insulin secretion [19]. In addition, calcitonin increases glucagon secretion, apparently, due to the decreasing of the total calcium content in blood serum, as it is known, that the decreasing of Ca 2+ ions concentration leads to the increasing of glucagon leaving from α-cells [20]. Apparently, by this way a reciprocive interrelations between calcitonin and parathyrin secretion and their effect on glucose and calcium metabolism occur, which reveals due to their modulating effect on insulin and glucagon secretion.…”

Section: Resultsmentioning

confidence: 99%

One-Time Injection of Parathyrin Increases Glucose Tolerance

Moisa¹,

Ноздрачев²

2013

OJEMD

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One-time injection of domestic preparation of bull parathyrin-parathyreoidin (1 U/100g body weight, intramuscular) leads to a significant decrease of the blood glucose level and an increase of the serum calcium level in rats. There is a close negative correlation established between glucose and calcium level (r = −0.813, P > 0.02). The calcium laktat load (9 mg) per os induces the same changes. There is a functional negative correlation established between glucose levels and total calcium content (r = −0.997, P < 0.01). It proves that the decrease of the blood glucose level under parathyrin injection is connected with hypercalcaemia. Parathyrin causes the reduction of the dynamics of hyperglycemia under the glucose load per os (30% solution, 1 ml/100g), i.e. parathyrin increases glucose tolerance. Glucose consumption by muscle (diaphragm) and adipose (epididymal) tissues in vivo and in vitro does not alter under parathyrin and it does not affect the stimulating effect of insulin on the process. The combinative effect of parathyrin and calcium channel blockers-isoptin (5 mg/kg, intraperitoneal) or nifedipin (1 mg/kg, intraperitoneal) reveals more intensive and lasting decrease of the blood glucose level in comparison with only parathyrin effect and more reduction of the dynamics of hyperglycemia under the glucose load. Thus, parathyrin decreases the blood glucose level, increases glucose tolerance and does not effect insulin resistance.

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Section: Resultsmentioning

confidence: 99%

One-Time Injection of Parathyrin Increases Glucose Tolerance

Moisa¹,

Ноздрачев²

2013

OJEMD

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“…However, there also exist some differences between the intestine and liver in lipid metabolism in animals. To our knowledge, it has been demonstrated that magnesium could decrease the glucagon content in the dog pancreas 20 , which could inhibit lipid synthesis in the animal liver (rather than in the animal intestine) 19 . Additionally, in animal livers, magnesium could activate the phosphatidylethanolamine N -methyltransferase pathway 21 , 22 to synthesize lecithin (an important lipid in the cytomembrane) in the liver (rather than in the intestine) 23 .…”

Section: Introductionmentioning

confidence: 88%

Dietary magnesium deficiency impaired intestinal structural integrity in grass carp (Ctenopharyngodon idella)

Wei

Jiang

et al. 2018

Sci Rep

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Grass carp (223.85–757.33 g) were fed diets supplemented with magnesium (73.54–1054.53 mg/kg) for 60 days to explore the impacts of magnesium deficiency on the growth and intestinal structural integrity of the fish. The results demonstrated that magnesium deficiency suppressed the growth and damaged the intestinal structural integrity of the fish. We first demonstrated that magnesium is partly involved in (1) attenuating antioxidant ability by suppressing Nrf2 signalling to decrease antioxidant enzyme mRNA levels and activities (except CuZnSOD mRNA levels and activities); (2) aggravating apoptosis by activating JNK (not p38MAPK) signalling to upregulate proapoptotic protein (Apaf-1, Bax and FasL) and caspase-2, -3, -7, -8 and -9 gene expression but downregulate antiapoptotic protein (Bcl-2, IAP and Mcl-1b) gene expression; (3) weakening the function of tight junctional complexes (TJs) by promoting myosin light chain kinase (MLCK) signalling to downregulate TJ gene expression [except claudin-7, ZO-2b and claudin-15 gene expression]. Additionally, based on percent weight gain (PWG), against reactive oxygen species (ROS), against caspase-9 and claudin-3c in grass carp, the optimal dietary magnesium levels were calculated to be 770.38, 839.86, 856.79 and 811.49 mg/kg, respectively.

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“…Possible, CT effect is depended on the stimulation of Ca 2+ leaving from α-cells and intercellular translocation of Ca 2+ [31]. The intensifying of glucagons secretion, induced CT, under insulin hypoglycemia, apparently, connected with hypocalcaemia, as far as it is established that the decreasing of Ca 2+ concentration leads to the increasing of glucagons removal from α-cells [32]. Further investigations will show, whether the increasing glucagons secretion, CT-induced against the background of hypoglycemia, take part in the realization of its diabetogenic action.…”

Section: Calcitonin and Glucose Metabolismmentioning

confidence: 98%

Calcitonin and Parathyrin are Glucoregulating Hormones

SS¹

2014

J Mol Genet Med

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The comprehensive literature data and our findings about calcium-regulating hormones participant in the glucose metabolism is analyzed. It is showed calcitonin hyperglycemic effect and its mechanisms, established contra-insulin effect of calcitonin to insulin under the pre-receptor, cell level and liver. It is ascertained the impairment of glucose metabolism under calcitonin -hyperglycemia, insulin resistance and glucose intolerance. It is showed the data of combinative effect of calcitonin and calcium antagonists on glucose metabolism. It is discussed calcitonindiabetogeniceffect and the role of calcium antagonists in the correction of hyperglycemia and tissue's insulin resistance. It was revealed the effect of parathyrin on glucose, occurring in decreasing the glucose level and increases glucose tolerance. It is concluded about participant of calcium-regulating hormones in theregulation of glucose metabolism.

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The Effect of Potassium, Calcium and Magnesium Concentration on Insulin and Glucagon Secretion of the Perfused Dog Pancreas

Cited by 5 publications

References 7 publications

One-Time Injection of Parathyrin Increases Glucose Tolerance

One-Time Injection of Parathyrin Increases Glucose Tolerance

Dietary magnesium deficiency impaired intestinal structural integrity in grass carp (Ctenopharyngodon idella)

Calcitonin and Parathyrin are Glucoregulating Hormones

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