The Effect of Postsurgical Antibiotics and a Bioabsorbable Membrane on Regenerative Healing in Class II Furcation Defects

Abstract

The administration of postsurgical antibiotics did not produce statistically superior osseous healing of Class II furcation defects. This result may be attributable to membrane design which facilitates connective tissue ingrowth, thereby preventing bacterial downgrowth and contamination of the newly regenerated tissues.

Treatment of Class II Molar Furcation Involvement: Meta‐Analyses of Reentry Results

“…The mean combined estimate that compared the resorbable with allograft and all other surgical procedures showed statistical improvements in outcomes of all four parameters (open flap debridement, 37 allograft against resorbable membranes with allograft ± antibiotic 40,44 ). The mean combined estimate showed a reduction in VPD of 0.81 ± 0.51 mm (95% CI, −0.20 to 1.81).…”

“…Title or abstract reviews were completed for these publications, yielding a total of 40 studies from the online search and 14 from the hand search (total of 54 papers). Of the 54 papers, a full‐text review concluded that only 34 articles met the specified inclusion criteria for the meta‐analyses 31‐64 …”

“…With regard to the combination of resorbable or non‐resorbable membranes with a bone graft for the regeneration of Class II defects, a meta‐analysis was not conducted because only two studies compared these treatment methods. The combined estimate effect, however, indicated favorable results for resorbable membrane with allograft/xenograft 32,35,37,40,44 compared to non‐resorbable membrane with allograft 40,65 (PD vertical reduction [3.05 versus 1.57 mm], CAL vertical gain [2.55 versus 1.38 mm], horizontal bone fill [2.58 versus 2.55 mm], vertical bone fill [2.25 versus 1.15 mm], respectively). The findings of the present study differ from other systematic reviews that showed vertical probing attachment–level enhancement only, by using expanded polytetrafluoroethylene and polymeric barriers 28 …”

“…The addition of allograft/xenograft to resorbable membranes 32,35,37,40,44 resulted in more improvement in all parameters compared to resorbable membranes alone 34,36,43,45,46,57,58,64 (PD vertical reduction [3.05 versus 2.07 mm]; CAL vertical gain [2.55 versus 1.39 mm]; horizontal bone gain [2.58 versus 1.85 mm]; and vertical bone gain [2.25 versus 1.49 mm]). These results differ from other systematic reviews that did not report significant enhancement by combining graft material and resorbable membranes 27,28 …”

Bacterial Penetration Through Antibiotic‐Loaded Guided Tissue Regeneration Membranes

“…A systemic antibiotic is usually prescribed after a GTR operation to reduce bacterial contamination and to prevent wound infection 15,21,22 . However, the results are not predictable 23,24 . Alternatively, the local application of antibiotics, including antibiotic solution irrigation, antibiotic gel, antibiotic fiber, or antibiotic‐loaded GTR membrane, 25–28 may be used during GTR therapy.…”