The Effect of Ponderal Index at Birth on the Relationships Between Common <i>LEP</i> and <i>LEPR</i> Polymorphisms and Adiposity in Adolescents

Labayen, Idoia; Ruiz, Jonatan R.; Moreno, Luís A.; Ortega, Francisco B.; Béghin, Laurent; DeHenauw, Stefaan; Benito, Pedro J.; Díaz, L. E.; Ferrari, Marco; Moschonis, George; Kafatos, Anthony; Molnár, Denés; Widhalm, Kurt; Dallongeville, Jean; Meirhaeghe, Aline; Gottrand, Frédéric

doi:10.1038/oby.2011.74

Cited by 19 publications

(19 citation statements)

References 48 publications

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“…The same allele has also shown retention of cancer-specific symptoms, if managed only with non-androgen deprivation treatment methods 101 . The SNPs rs130067, rs10244329, and rs12529 have been previously reported by groups working on various diseases related to and causing PCa in Caucasian populations such as rheumatoid arthritis 13 , obesity 102 , and sex hormone metabolic pathway 11,103,104 respectively. The rs12529 SNP is also related to lung cancer 105 and bladder cancer 106 .…”

Section: Snp Genotype Analysis Of Aggressive Prostate Cancer Vs Healtmentioning

confidence: 87%

Environmental factors and risk of aggressive prostate cancer among a population of New Zealand men – a genotypic approach

et al. 2017

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Prostate cancer is one of the most significant health concerns for men worldwide. Numerous researchers carrying out molecular diagnostics have indicated that genetic interactions with biological and behavioral factors play an important role in the overall risk and prognosis of this disease. Single nucleotide polymorphisms (SNPs) are increasingly becoming strong biomarker candidates to identify susceptibility to prostate cancer. We carried out a gene × environment interaction analysis linked to aggressive and non-aggressive prostate cancer (PCa) with a number of SNPs. By using this method, we identified the susceptible alleles in a New Zealand population, and examined the interaction with environmental factors. We have identified a number of SNPs that have risk associations both with and without environmental interaction. The results indicate that certain SNPs are associated with disease vulnerability based on behavioral factors. The list of genes with SNPs identified as being associated with the risk of PCa in a New Zealand population is provided in the graphical abstract.

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Section: Snp Genotype Analysis Of Aggressive Prostate Cancer Vs Healtmentioning

confidence: 87%

Environmental factors and risk of aggressive prostate cancer among a population of New Zealand men – a genotypic approach

et al. 2017

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“…Future research is needed to clarify the role of SERPINF1 in the determination of bodyweight. Findings for the LEP gene and body mass have also been mixed with both positive and negative reports [59]. …”

Section: Discussionmentioning

confidence: 99%

Familial Risk for Alcohol Dependence and Developmental Changes in BMI: The Moderating Influence of Addiction and Obesity Genes

et al. 2014

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Aim Familial loading for alcohol dependence (AD) and variation in genes reported to be associated with AD or BMI were tested in a longitudinal study. Materials & methods Growth curve analyses of BMI data collected at approximately yearly intervals and obesity status (BMI > 30) were examined. Results High-risk males were found to have higher BMI than low-risk males, beginning at age 15 years (2.0 kg / m2 difference; p = 0.046), persisting through age 19 years (3.3 kg/m2 difference; p = 0.005). CHRM2 genotypic variance predicted longitudinal BMI and obesity status. Interactions with risk status and sex were also observed for DRD2 and FTO gene variation. Conclusion Variation at loci implicated in addiction may be influential in determining susceptibility to increased BMI in childhood and adolescence.

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“…3) in the X chromosomes of all 31 pigs. This region had extremely low recombination (48 Mb segment, 44.0-91.5 Mb [15,39]; and spanned the centromeric region (47.3-49.2 Mb). We observed three major haplotypes after selecting SNP markers with inter-marker distances of 3 Kb.…”

Section: Selective Signatures From Cnsouth and Cnnorthmentioning

confidence: 99%

“…These nonsynonymous substitutions were putative candidate polymorphisms that resulted in size differences. Indeed, two genes (LEPR and FANCC) overlapping with nonsynonymous substitutions are reported as associated with body growth and development in some mammals [43,44]. In humans, impaired LEPR function exerts a strong negative effect on ponderal index at birth and height in adolescence [44].…”

Section: Identification Of Candidate Genes For Body Sizementioning

confidence: 99%

“…Indeed, two genes (LEPR and FANCC) overlapping with nonsynonymous substitutions are reported as associated with body growth and development in some mammals [43,44]. In humans, impaired LEPR function exerts a strong negative effect on ponderal index at birth and height in adolescence [44]. Likewise, FANCC plays a major role in skeletal formation, and thus affects human height [45,46].…”

Section: Identification Of Candidate Genes For Body Sizementioning

confidence: 99%

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Genome-Wide Analysis Reveals Genetic Structure and Selective Sweeps in Chinese Indigenous Pig Breeds

Tong

Hou

et al. 2019

Preprint

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Background Chinese indigenous pigs exhibit considerable phenotypic diversity, but their population structure and the genetic basis of agriculturally important traits have not been explored. Results Here, we sequenced the whole genomes of 24 individual pigs representing 22 breeds distributed throughout China. For comparison with European and commercial breeds (one pig per breed), we integrated seven published pig genomes with our new genomes. Our results showed that pig domestication occurred at three places in Southeastern Asia, namely the Mekong region, the middle to downstream regions of the Yangtze River, and Tibetan highlands. Moreover, we demonstrated that classic morphological characteristics such as coat color are not consistent with genetic data. We found that genetic material from European pigs likely introgressed into five Chinese breeds. Two new subpopulations of domestic pigs have been identified in South and North China that encompass morphology-based criteria. The Southern Chinese subpopulation comprises the classical Southern China Type and part of the Central China Type, whereas the Northern Chinese subpopulation comprises the North China Type, the Lower Yangtze River Basin Type, the Southwest Type, the Plateau Type, and the remainder of the Central China Type. Eight haplotypes and two recombination sites were identified within a conserved 40.09 Mb linkage-disequilibrium block on the X chromosome. Potential selection and domestication signatures were identified, mainly influencing body size, along with adaptations to cold and hot temperature environments. Conclusions Our findings provide insights into the phylogeny of Chinese indigenous pig breeds, and will be of enormous benefit in identifying beneficial genes to develop superior pig breeds.

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The Effect of Ponderal Index at Birth on the Relationships Between Common LEP and LEPR Polymorphisms and Adiposity in Adolescents

Cited by 19 publications

References 48 publications

Environmental factors and risk of aggressive prostate cancer among a population of New Zealand men – a genotypic approach

Environmental factors and risk of aggressive prostate cancer among a population of New Zealand men – a genotypic approach

Familial Risk for Alcohol Dependence and Developmental Changes in BMI: The Moderating Influence of Addiction and Obesity Genes

Genome-Wide Analysis Reveals Genetic Structure and Selective Sweeps in Chinese Indigenous Pig Breeds

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