“…Various studies (Battino et al, 1999;Chidambara et al, 2002;Seeram et al, 2005;Menezes et al, 2006;Lansky & Newman, 2007;DiSilvestro & DiSilvestro, 2009;Kiany et al, 2016;Umar et al, 2016;Deepak & Samuel, 2018;Pedersen et al, 2019) have shown that pomegranate contains agents, especially polyphenolic flavonoids like punicalagins and ellagic acid that result in reduction of oxidative stress in oral cavity, direct anti-oxidant activity, antibacterial activity, and direct removal of plaque from the teeth by discouraging the action of the microorganisms that initiate plaque formation. Moreover, inhibiting prostaglandin and leukotriene formation through inhibition of the eicosanoids enzymes, cyclooxygenase and lipoxygenase, raises the possibility of the use of pomegranate derivatives in anti-inflammatory preparations (Kiany et al, 2016).…”