The effect of pomegranate extract on anthropometric indices, serum lipids, glycemic indicators, and blood pressure in patients with nonalcoholic fatty liver disease: A randomized double‐blind clinical trial

Goodarzi, Reza; Jafarirad, Sima; Mohammadtaghvaei, Narges; Dastoorpoor, Maryam; Alavinejad, Pejman

doi:10.1002/ptr.7249

Cited by 19 publications

(26 citation statements)

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“…In addition, there were no differences between the Test and Control groups in physical and hematological parameters. In line with previous results dealing with protein or pomegranate supplementation [ 25 , 26 ], a decrease in systolic and diastolic blood pressure was observed between the start and the end of the study in both groups. While beyond the primary scope of the present study, these results suggest beneficial actions of protein and protein/pomegranate supplementation on blood pressure.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study

Dormal

Pachikian²,

Debock³

et al. 2022

Nutrients

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Malnutrition is a highly prevalent condition in older adults. It is associated with low muscle mass and function and increased occurrence of health problems. Maintaining an adequate nutritional status as well as a sufficient nutrient intake in older people is therefore essential to address this public health problem. For this purpose, protein supplementation is known to prevent the loss of muscle mass during aging, and the consumption of various pomegranate extracts induces numerous health benefits, mainly through their antioxidant properties. However, to our knowledge, no study has to date investigated the impact of their combination on the level of malnutrition in older people. The objective of this preliminary study was thus to evaluate the safety of a combination of protein and a pomegranate extract in healthy subjects aged 65 years or more during a 21-day supplementation period. Thirty older participants were randomly assigned to receive protein and a pomegranate extract (Test group) or protein and maltodextrin (Control group) during a 21-day intervention period. The primary outcomes were the safety and tolerability of the supplementation defined as the occurrence of adverse events, and additional secondary outcomes included physical examination and hematological and biochemical parameters. No serious adverse events were reported in any group. Changes in physical, hematological, and biochemical parameters between the initial screening and the end of the study were equivalent in both groups, except for glutamate-pyruvate transaminase (GPT) and prealbumin, for which a decrease was observed only in the Test group. Our initial findings support the safety of the combination of protein and a pomegranate extract in healthy elderly people. Future clinical trials on a larger sample and a longer period are needed to determine the efficacy of this combination.

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Section: Discussionsupporting

confidence: 92%

Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study

Dormal

Pachikian²,

Debock³

et al. 2022

Nutrients

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show abstract

“…Moreover, the intervention duration varied from 2 weeks (Kojadinovic et al, 2021;Manthou et al, 2017) to 24 (Wu et al, 2015) weeks, and the sample size differed from 10 ( Manthou et al, 2017) to 77 (Park et al, 2014) participants. The design of 26 trials was parallel RCT (Abedini et al, 2021;Akbarpour et al, 2021;Al-Dujaili et al, 2022;Babaeian et al, 2013;Esmaeilinezhad et al, 2019;Faghihimani et al, 2016;González-Ortiz et al, 2011;Goodarzi et al, 2021;Grabež et al, 2020;Hosseini et al, 2016;Irani et al, 2020;Kojadinovic et al, 2017Kojadinovic et al, , 2021Lynn et al, 2012;Manthou et al, 2017;Mirmiran et al, 2010;Nemati et al, 2022;Park et al, 2014;Rouzbehan et al, 2021;Sohrab et al, 2014Sohrab et al, , 2019Stockton et al, 2017;Sumner et al, 2005;Wu et (Tsang et al, 2012), healthy young and middle-aged men and women (Lynn et al, 2012), type 2 diabetic individuals (Babaeian et al, 2013;Faghihimani et al, 2016;Grabež et al, 2020;Nemati et al, 2022;Sohrab et al, 2014Sohrab et al, , 2019Yarmohammadi & Mahjoub, 2017), overweight participants (Park et al, 2014), hemodialysis patients …”

Section: Study Characteristicmentioning

confidence: 99%

“…The design of 26 trials was parallel RCT (Abedini et al, 2021;Akbarpour et al, 2021;Al-Dujaili et al, 2022;Babaeian et al, 2013;Esmaeilinezhad et al, 2019;Faghihimani et al, 2016;González-Ortiz et al, 2011;Goodarzi et al, 2021;Grabež et al, 2020;Hosseini et al, 2016;Irani et al, 2020;Kojadinovic et al, 2017Kojadinovic et al, , 2021Lynn et al, 2012;Manthou et al, 2017;Mirmiran et al, 2010;Nemati et al, 2022;Park et al, 2014;Rouzbehan et al, 2021;Sohrab et al, 2014Sohrab et al, , 2019Stockton et al, 2017;Sumner et al, 2005;Wu et (Tsang et al, 2012), healthy young and middle-aged men and women (Lynn et al, 2012), type 2 diabetic individuals (Babaeian et al, 2013;Faghihimani et al, 2016;Grabež et al, 2020;Nemati et al, 2022;Sohrab et al, 2014Sohrab et al, , 2019Yarmohammadi & Mahjoub, 2017), overweight participants (Park et al, 2014), hemodialysis patients (Barati Boldaji et al, 2020;Wu et al, 2015), overweight and obese individuals (Hosseini et al, 2016;Zarezadeh et al, 2019), healthy participants (Al-Dujaili et al, 2022;Manthou et al, 2017;…”

Section: Study Characteristicmentioning

confidence: 99%

“…agonist (Goodarzi et al, 2021;Rachid et al, 2015). PPAR-α activation induces fatty acid oxidation in the liver and muscles and contributes to the improvement of lipid profile and reduction of adiposity (Evans et al, 2004).…”

Section: Body Weightmentioning

confidence: 99%

“…Mirmiran et al, 2010;Nemati et al, 2022;Rouzbehan et al, 2021;Sohrab et al, 2014Sohrab et al, , 2019Yarmohammadi & Mahjoub, 2017;Zarezadeh et al, 2019), Mexico(González-Ortiz et al, 2011), South Korea(Park et al, 2014), Scotland(Stockton et al, 2017), Serbia(Kojadinovic et al, 2017(Kojadinovic et al, , 2021, Greece(Manthou et al, 2017), and Bosnia and Herzegovina(Grabež et al, 2020). Seven studies were performed on females(Abedini et al, 2021;Akbarpour et al, 2021;Esmaeilinezhad et al, 2019;Kojadinovic et al, 2017;Park et al, 2014;Rouzbehan et al, 2021;Yarmohammadi & Mahjoub, 2017), two studies on males(Irani et al, 2020;Nemati et al, 2022), and the others were carried out on both genders(Al-Dujaili et al, 2022;Babaeian et al, 2013;Barati Boldaji et al, 2020;Faghihimani et al, 2016;González-Ortiz et al, 2011;Goodarzi et al, 2021;Grabež et al, 2020;Hosseini et al, 2016;Kojadinovic et al, 2021;Lynn et al, 2012;Manthou et al, 2017;Mirmiran et al, 2010;Sohrab et al, 2014Sohrab et al, , 2019Stockton et al, 2017;Sumner et al, 2005;Tsang et al, 2012;…”

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confidence: 99%

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The effects of pomegranate consumption on obesity indices in adults: A systematic review and meta‐analysis

Bahari,

Pourreza,

Goudarzi

et al. 2023

Food Science & Nutrition

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Evidence supports the potential application of polyphenols as agents against obesity. Pomegranate is one of the fruits that possess a high content of polyphenols. This systematic review and meta‐analysis of randomized controlled trials (RCTs) sought to evaluate the effects of pomegranate consumption on obesity indices, including body mass index (BMI), body weight, waist circumference (WC), fat mass (FM), body fat percentage (BFP), and fat‐free mass (FFM) in adults. Relevant RCTs were obtained by searching databases, including PubMed, SCOPUS, and Web of Science, up to May 2023. Heterogeneity tests of the included trials were performed using the I2 statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference with a 95% confidence interval. Pooled analysis of 28 trials revealed that pomegranate consumption led to a significant reduction in body weight (WMD: −1.97, 95% CI: −2.91, −1.03, p < .05), and a significant decrease in BMI (WMD: −0.48, 95% CI: −0.76, −0.20, p < .05) in comparison with the control group. However, there were no significant effects on WC, FM, FFM, and BFP in comparison with the control group. Pomegranate consumption may yield a beneficial effect on body weight and BMI in adults. However, there were no significant effects on WC, FM, FFM, and BFP, by pomegranate consumption. Also, pomegranate consumption can reduce body weight, BMI, WC, and BFP in obese adults. Long‐term trials with different doses of pomegranate are needed.

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A review of experimental and clinical studies on the therapeutic effects of pomegranate (Punica granatum) on non‐alcoholic fatty liver disease: Focus on oxidative stress and inflammation

Zamanian,

Sadeghi Ivraghi,

Khachatryan

et al. 2023

Food Science & Nutrition

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Non‐alcoholic fatty liver disease (NAFLD) is frequently linked to metabolic disorders and is prevalent in obese and diabetic patients. The pathophysiology of NAFLD involves multiple factors, including insulin resistance (IR), oxidative stress (OS), inflammation, and genetic predisposition. Recently, there has been an emphasis on the use of herbal remedies with many people around the world resorting to phytonutrients or nutraceuticals for treatment of numerous health challenges in various national healthcare settings. Pomegranate (Punica granatum) parts, such as juice, peel, seed and flower, have high polyphenol content and is well known for its antioxidant capabilities. Pomegranate polyphenols, such as hydrolyzable tannins, anthocyanins, and flavonoids, have high antioxidant capabilities that can help lower the OS and inflammation associated with NAFLD. The study aimed to investigate whether pomegranate parts could attenuate OS, inflammation, and other risk factors associated with NAFLD, and ultimately prevent the development of the disease. The findings of this study revealed that: 1. pomegranate juice contains hypoglycemic qualities that can assist manage blood sugar levels, which is vital for avoiding and treating NAFLD. 2. Polyphenols from pomegranate flowers increase paraoxonase 1 (PON1) mRNA and protein levels in the liver, which can help protect liver enzymes and prevent NAFLD. 3. Punicalagin (PU) is one of the major ellagitannins found in pomegranate, and PU‐enriched pomegranate extract (PE) has been shown to inhibit HFD‐induced hyperlipidemia and hepatic lipid deposition in rats. 4. Pomegranate fruit consumption, which is high in antioxidants, can decrease the activity of AST and ALT (markers of liver damage), lower TNF‐α (a marker of inflammation), and improve overall antioxidant capacity in NAFLD patients. Overall, the polyphenols in pomegranate extracts have antioxidant, anti‐inflammatory, hypoglycemic, and protective effects on liver enzymes, which can help prevent and manage NAFLD effects on liver enzymes, which can help prevent and manage NAFLD.

show abstract

The effect of pomegranate extract on anthropometric indices, serum lipids, glycemic indicators, and blood pressure in patients with nonalcoholic fatty liver disease: A randomized double‐blind clinical trial

Cited by 19 publications

References 50 publications

Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study

Evaluation of a Dietary Supplementation Combining Protein and a Pomegranate Extract in Older People: A Safety Study

The effects of pomegranate consumption on obesity indices in adults: A systematic review and meta‐analysis

A review of experimental and clinical studies on the therapeutic effects of pomegranate (Punica granatum) on non‐alcoholic fatty liver disease: Focus on oxidative stress and inflammation

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