The Effect of Polyphenols in Olive Oil on Heart Disease Risk Factors

Covas, Marı́a-Isabel; Nyyssönen, Kristiina; Poulsen, Henrik E.; Kaikkonen, Jari; Zunft, Hans-Joachim F.; Kiesewetter, H.; Gaddi, Antonio Vittorino; Torre, Rafael de la; Mursu, Jaakko; Bäumler, Hans; Nascetti, Simona; Salonen, Jukka T.; Fitó, Montserrat; Virtanen, Jyrki K.; Marrugat, Jaume

doi:10.7326/0003-4819-145-5-200609050-00006

Cited by 663 publications

(514 citation statements)

References 38 publications

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“…An international study with a large sample size has been conducted on humans (Covas et al, 2006) but not, to our knowledge, on animals.…”

Section: Blood Analysesmentioning

confidence: 99%

Influence of Lippia citriodora verbascoside on growth performance, antioxidant status, and serum immunoglobulins content in piglets

Pastorelli¹,

Rossi²,

Corino³

2012

CZECH J ANIM SCI

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Phytogenic feed additives are used in animal feeding to improve livestock performance. The aim of this study was to determine whether a dietary plant extract from Lippia citriodora, standardized for verbascoside, can modify various immunological, oxidative, and biochemical serum parameters in weaned piglets. A total of 144 piglets, half female and half barrows (7.99 ± 1.40 kg BW), were allocated to three dietary treatments with six replicates per treatment (pens of 8 piglets each). Piglets were supplemented with the following levels of plant extract standardized for verbascoside: 0 (CON = control group), 5 (LV = low verbascoside group), or 10 (HV = high verbascoside group) mg/kg of diet for 56 days. Body weight (BW) and feed consumption were recorded at days 0 and 56 to determine the average daily gain and gain : feed. Twelve piglets from each treatment were randomly selected, and blood was collected by anterior vena cava puncture on days 0, 14, and 56 for glucose, triglycerides, cholesterol, urea, and oxidative status, and on days 0 and 56 for IgG and IgA concentrations. The HV group grew more (P < 0.05) than the CON and LV groups. No significant differences were observed for any of the biochemical parameters between the groups; urea, high density lipoprotein cholesterol, total cholesterol, and low density lipoprotein cholesterol increased significantly over time. Reactive oxygen metabolites (ROM) showed significant time, time × treatment, and treatment effects (P < 0.001). Both serum Igs increased (P < 0.005, P < 0.001 for IgG and IgA respectively) over time in all groups; treatment (P < 0.05), and time × treatment (P = 0.056) effects were found for serum IgA concentration. The Lippia citriodora verbascoside positively influenced antioxidant status and IgA content with a tendential effect on growth performance.

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“…An international study with a large sample size has been conducted on humans (Covas et al, 2006) but not, to our knowledge, on animals.…”

Section: Blood Analysesmentioning

confidence: 99%

Influence of Lippia citriodora verbascoside on growth performance, antioxidant status, and serum immunoglobulins content in piglets

Pastorelli¹,

Rossi²,

Corino³

2012

CZECH J ANIM SCI

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“…The beneficial effects of olive oil are mainly attributed to polyphenols, in particular the antioxidant action. These compounds can exert an antioxidant effect in vivo, in particular in the postprandial phase according to Bonanome et al 48 They are also considered as dietary nutrients of the Mediterranean diet 49 . According to a study carried out by a European group, two oils were tested: a virgin olive oil very rich in polyphenols (366 mg/kg), a mixed oil obtained from a mixture of virgin olive oil, Refined olive oil, moderately rich in polyphenols (164 mg/kg), showed that olive oil rich in polyphenols exhibits antioxidant action and increases HDL-cholesterol 50 .…”

Section: Discussionmentioning

confidence: 99%

Analysis of bioactive minor compounds in three olive oils from varieties of olive tree eastern Algerian (Bouricha, Limli and Blanquette).

Benrachou¹,

lynda²,

Henchiri

2016

JNR

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The study of bioactive compounds on the health of the unsaponifiable fraction of three olive oils from three cultivars of eastern Algeria carried out by gas chromatography revealed the presence of 11 compounds with the predominance of b-Sitosterol, Sterol characteristic of olive oils and having a nutritional and pharmacological value. The highest content was found in Limli oil (81.59%). Two triterpene dialcohols were chromatographed with sterols (erythrodiol and uvaol), the content of which can be identified fraud and to detect whether the virgin oil is mixed with the oil of pomace. Analysis of the alcohol fraction by GPC-FID revealed the predominance of a triterpene alcohol, 24-methylene cycloarenol for the three varieties with a higher content for Blanquette (48.03%) followed by cycloarenol. For the aliphatic alcohols, the analysis shows the predominance of four alcohols with 22, 23, 24 and 28 carbon atoms whose contents are higher for Limli oil. The spectrophotometric determination of antioxidant pigments shows that Limli oil is richer in chlorophylls with an average of 13.53 mg / kg and a significantly higher carotenoid content for Bouricha and Limli (13.10 -12.82 mg / Kg). The total polyphenols were lower for Blanquette (83.36 mg / kg) compared with Bouricha and Limli (133.3 mg / kg and 121.3 mg / kg), making them more stable during oxidation storage and whose beneficial effects of olive oil are mainly attributed to these substances, in particular the antioxidant action that would protect against diseases of oxidative stress.

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“…The European Study of the Antioxidant Effects of Olive Oil and its Phenolic Compounds on lipid oxidation (EUROLIVE) study (Covas et al, 2006) was a clinical trial to evaluate the effects of the phenolic content in olive oil on the plasma lipid profile and lipid oxidative damage. The systemic markers of lipid oxidation decreased inversely with the phenolic content of the olive oil (particularly low density lipoprotein (LDL) oxidation markers) and high density lipoprotein (HDL) cholesterol levels increased in a direct relationship with the phenolic content of the olive oil.…”

Section: The Mediterranean Diet's Effect On Oxidation and Inflammatiomentioning

confidence: 99%

Cardiovascular risk protection from the Mediterranean diet and olive oil. A transcriptomic update in humans

2016

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SUMMARY: This review highlights the human studies that explore the benefits of the Mediterranean diet and olive oil, based on gene expression analysis. We summarized consistent human transcriptomic studies on cardiovascular risk, based on TMD and olive oil interventions, with real life doses and conditions. A literature review was carried out leading up to February 2016. The results show that the TMD, specially supplemented with virgin olive oil, produces beneficial changes in the transcriptomic response of relevant genes in cardiovascular risk such as CAT, GPX1 and SIRT2. p65 and MCP-1, IL1B, IL6, CXCL1, INF-γ, ARHGAP15 and IL7R, which are involved in inflammation; and ABCA1, SR-B1, PPARBP, PPARα, PPARγ, PPARδ, CD-36 and COX-1, which play an important role in cholesterol efflux. The available data illustrate a transcriptomic effect on atherosclerosis, inflammation and oxidative stress pathways as well as the mentioned genes.KEYWORDS: Cardiovascular; Mediterranean Diet; MUFA; Nutrigenomics; Olive oil; Polyphenols; Transcriptomics RESUMEN: Protección cardiovascular de la dieta mediterránea y el aceite de oliva. Una actua lización de transcriptómica en humanos. Esta revisión resume los estudios de transcriptómica en humanos que muestran efectos beneficiosos de la dieta mediterránea tradicional (TMD) y el aceite de oliva, en condiciones y dosis de la vida real en relación al riesgo cardiovascular. La revisión se llevó a cabo hasta febrero de 2016. Los resultados muestran que la TMD, especialmente suplementada con aceite de oliva virgen, ejerce cambios beneficiosos en la respuesta transcriptómica de genes relevantes en el riesgo cardiovascular tales como CAT, GPX1 y SIRT2. p65 y MCP-1, IL1B, IL6, CXCL1, INF-γ, ARHGAP15 y IL7R implicados en la inflamación. ABCA1, SR-B1, PPARBP, PPARα, PPARγ, PPARδ, CD-36 y la COX-1 juegan un papel importante en el eflujo de colesterol. Además, ADRB2 está relacionada con el estrés oxidativo. Los datos disponibles nos llevan a un efecto transcriptómico sobre las vías de arteriosclerosis, inflamación y estrés oxidativo, así como sobre los genes mencionados.

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The Effect of Polyphenols in Olive Oil on Heart Disease Risk Factors

Abstract: Olive oil is more than a monounsaturated fat. Its phenolic content can also provide benefits for plasma lipid levels and oxidative damage. International Standard Randomised Controlled Trial number: ISRCTN09220811.

Cited by 663 publications

References 38 publications

Influence of Lippia citriodora verbascoside on growth performance, antioxidant status, and serum immunoglobulins content in piglets

Influence of Lippia citriodora verbascoside on growth performance, antioxidant status, and serum immunoglobulins content in piglets

Analysis of bioactive minor compounds in three olive oils from varieties of olive tree eastern Algerian (Bouricha, Limli and Blanquette).

Cardiovascular risk protection from the Mediterranean diet and olive oil. A transcriptomic update in humans

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