The effect of polyethylene glycol and butyrate on anastomotic healing in the rat colon

Fa-Si-Oen, Patrick; Gender, P van de; Putter, Hein; Ectors, Nadine; D’Hoore, André; Topal, Baki; Penninckx, Freddy

doi:10.1007/s10151-006-0298-6

Cited by 3 publications

(2 citation statements)

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“…[140][141][142] Moreover, in vitro models have shown that both inulin and GOS are microbially fermented into SCFAs in considerable amounts. [143][144][145][146][147] Longer-term inulin supplementation caused reductions in body weight, BMI, as well as energy and fat intake in patients with type 2 diabetes. 148 Replacing digestible carbohydrates with inulin for three to eight weeks in healthy subjects reduced plasma lipid concentrations, 141,[149][150][151][152][153] and lowered fasting glucose and insulin concentrations.…”

Section: Chapter 1 Prebioticsmentioning

confidence: 99%

“…50 Again, other animal studies found positive effects of SCFAs on mucosal healing and prevention of adhesions. 45,[145][146][147][148][149][150] human epidemiological studies Gut microbial dysbiosis might play a role in the onset or treatment of gastrointestinal disease. The consumption of specific carbohydrates influences the composition and function of the human microbiome.…”

Section: Mucosal Healing and Colonic Protectionmentioning

confidence: 99%

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The gut in control of health and disease

Beek¹

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Section: Chapter 1 Prebioticsmentioning

confidence: 99%

Section: Mucosal Healing and Colonic Protectionmentioning

confidence: 99%

The gut in control of health and disease

Beek¹

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Role of short-chain fatty acids in colonic inflammation, carcinogenesis, and mucosal protection and healing

Dejong²,

et al. 2017

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Short-chain fatty acids (SCFAs), mainly acetate, propionate, and butyrate, produced by microbial fermentation of undigested food substances are believed to play a beneficial role in human gut health. Short-chain fatty acids influence colonic health through various mechanisms. In vitro and ex vivo studies show that SCFAs have anti-inflammatory and anticarcinogenic effects, play an important role in maintaining metabolic homeostasis in colonocytes, and protect colonocytes from external harm. Animal studies have found substantial positive effects of SCFAs or dietary fiber on colonic disease, but convincing evidence in humans is lacking. Most human intervention trials have been conducted in the context of inflammatory bowel disease. Only a limited number of those trials are of high quality, showing little or no favorable effect of SCFA treatment over placebo. Opportunities for future research include exploring the use of combination therapies with anti-inflammatory drugs, prebiotics, or probiotics; the use of prodrugs in the setting of carcinogenesis; or the direct application of SCFAs to improve mucosal healing after colonic surgery.

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Enhancing intestinal anastomotic healing using butyrate: Systematic review and meta-analysis of experimental animal studies

et al. 2023

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Background Despite advancements in surgical technique and perioperative care, intestinal anastomoses still have a 10–15 per cent risk of leakage, which results in considerable morbidity and/or mortality. Recent animal studies have suggested that administration of butyrate to the anastomotic site results in enhanced anastomotic strength, which may prevent leakage. This systematic review and meta-analysis summarises current evidence concerning the effect of butyrate administration on anastomotic healing and will form a scientific basis for the development of new research into this subject. Methods Animal studies on the effect of butyrate-based interventions in models of intestinal anastomotic healing were systematically retrieved from online databases. Bibliographical data, study characteristics and outcome data were extracted, and internal validity of the studies was assessed. Outcomes studied through meta-analysis concerned: anastomotic strength, anastomotic leakage, collagen metabolism and general histologic parameters of wound healing. Results A comprehensive search and selection identified 19 relevant studies containing 41 individual comparisons. Design and conduct of most experiments were poorly reported resulting in an unclear risk of bias. Meta-analyses showed that butyrate administration significantly increases anastomotic strength (SMD 1.24, 0.88 to 1.61), collagen synthesis (SMD 1.44, 0.72 to 2.15) and collagen maturation, making anastomoses less prone to leakage in the early postoperative period (OR 0.37, 0.15 to 0.93). Conclusion This systematic review and meta-analysis shows that there is potential ground to investigate the use of butyrate in clinical trials to prevent anastomotic leakage in intestinal surgery. However, more research is necessary to define the best application form, dosage and administration route.

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The effect of polyethylene glycol and butyrate on anastomotic healing in the rat colon

Abstract: PEG does not interfere with anastomotic healing in rats as measured by BP. No benefit of a single dose of butyrate was observed.

Cited by 3 publications

References 23 publications

The gut in control of health and disease

The gut in control of health and disease

Role of short-chain fatty acids in colonic inflammation, carcinogenesis, and mucosal protection and healing

Enhancing intestinal anastomotic healing using butyrate: Systematic review and meta-analysis of experimental animal studies

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