The effect of poly(lactic‐co‐glycolic acid) conduit loading insulin‐like growth factor 1 modified by a <scp>collagen‐binding</scp> domain on peripheral nerve injury in rats

Zhang, Jun; Zhang, Yan; Jiang, Yi Kun; Li, Jian An; Wei, Wan Fu; Shi, Mingpeng; Wang, Yan Bing; Gui, Jia

doi:10.1002/jbm.b.35064

Cited by 6 publications

(5 citation statements)

References 25 publications

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“…Collagen has previously been described in clinical applications for nerve wrapping after peripheral nerve surgery [52][53][54][55]. Next to promising results in clinical testing, animal models have confirmed several positive effects of collagen, including immunomodulation [56], neuroregeneration [47,[57][58][59], and pain alleviation after peripheral nerve injury [53,60]. Several collagen-based nerve wraps and conduits are available on the market and approved for in-patient use, bringing this technique from bench to bedside.…”

Section: Discussionmentioning

confidence: 99%

Shielding the Nerve: A Systematic Review of Nerve Wrapping to Prevent Adhesions in the Rat Sciatic Nerve Model

Mayrhofer-Schmid,

Klemm,

Aman

et al. 2023

JPM

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Background: Peripheral nerve pathology is frequently encountered in clinical practice among peripheral nerve and extremity surgeons. One major factor limiting nerve regeneration and possibly leading to revision surgeries is the development of traumatic or postoperative adhesions and scarring around nerves. In experimental models, different materials have been studied to limit scar tissue formation when wrapped around nerves. Methods: A systematic review of studies describing nerve-wrapping materials in a non-transectional rat sciatic nerve model was performed following the PRISMA guidelines. Literature describing nerve-wrapping methods for the prevention of peripheral nerve scarring in rat sciatic nerve models was identified using PubMed and Web of Science, scanned for relevance and analyzed. Results: A total of 15 original articles describing 23 different materials or material combinations for nerve wrapping were included. The heterogeneity of the methods used did not allow a meta-analysis, thus, a systematic review was performed. Out of 28 intervention groups, 21 demonstrated a preventive effect on scar tissue formation in at least one qualitative or quantitative assessment method. Conclusions: The analyzed literature describes a variety of materials from different origins to limit peripheral nerve scarring and adhesions. Thus, a scar-preventive effect by wrapping peripheral nerves as adhesion prophylaxis seems likely. However, a quantitative comparison of the studies to identify the optimal material or technique is not possible with the diversity of used models and study designs. Therefore, further research needs to be performed to identify the optimal nerve wraps to be used routinely in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Shielding the Nerve: A Systematic Review of Nerve Wrapping to Prevent Adhesions in the Rat Sciatic Nerve Model

Mayrhofer-Schmid,

Klemm,

Aman

et al. 2023

JPM

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“…Wang W.C. showed accelerated restoration of motor function in injured sciatic nerve using nerve guidance conduits based on gelatin/silk hydrogel, including linearly aligned magnetic PLGA microcapsules encapsulating nerve growth factor [ 181 ]. Zhang J. obtained a similar positive effect using collagen-coated PLGA conduits loaded with insulin-like growth factor 1 modified by a collagen-binding domain [ 182 ], while Chung Y.F. obtained a similar effect using PLGA conduits releasing IL-12 [ 183 ].…”

Section: Neurologic Diseasesmentioning

confidence: 99%

Use of Poly Lactic-co-glycolic Acid Nano and Micro Particles in the Delivery of Drugs Modulating Different Phases of Inflammation

et al. 2023

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Chronic inflammation contributes to the pathogenesis of many diseases, including apparently unrelated conditions such as metabolic disorders, cardiovascular diseases, neurodegenerative diseases, osteoporosis, and tumors, but the use of conventional anti-inflammatory drugs to treat these diseases is generally not very effective given their adverse effects. In addition, some alternative anti-inflammatory medications, such as many natural compounds, have scarce solubility and stability, which are associated with low bioavailability. Therefore, encapsulation within nanoparticles (NPs) may represent an effective strategy to enhance the pharmacological properties of these bioactive molecules, and poly lactic-co-glycolic acid (PLGA) NPs have been widely used because of their high biocompatibility and biodegradability and possibility to finely tune erosion time, hydrophilic/hydrophobic nature, and mechanical properties by acting on the polymer’s composition and preparation technique. Many studies have been focused on the use of PLGA-NPs to deliver immunosuppressive treatments for autoimmune and allergic diseases or to elicit protective immune responses, such as in vaccination and cancer immunotherapy. By contrast, this review is focused on the use of PLGA NPs in preclinical in vivo models of other diseases in which a key role is played by chronic inflammation or unbalance between the protective and reparative phases of inflammation, with a particular focus on intestinal bowel disease; cardiovascular, neurodegenerative, osteoarticular, and ocular diseases; and wound healing.

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“…Gong et al [16] used an NGC filled with a hydrogel mimicking the extracellular matrix basement membrane. Zhang et al [17] designed a collagen-coated PLGA conduit loaded with insulin-like growth factor 1. Yao et al [18] designed a PCL conduit filled with magnesium ion-encapsulating nanocomposite hydrogel.…”

Section: Nerve Guide Conduitsmentioning

confidence: 99%

Nerve guide conduits, nerve transfers, and local and free muscle transfer in facial nerve palsy

Shoman

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of review To highlight the recent literature on reinnervation options in the management of facial nerve paralysis using nerve conduits, and nerve and muscle transfers. Recent findings Engineering of natural and synthetic nerve conduits has progressed and many of these products are now available on the market. The use of the masseter nerve has become more popular recently as a choice in nerve transfer procedures due to various unique advantages. Various authors have recently described mimetic muscle reinnervation using more than one nerve transfer, as well as dual and triple innervation of free muscle transfer. Summary The ideal nerve conduit continues to be elusive, however significant progress has been made with many natural and synthetic materials and designs tested and introduced on the market. Many authors have modified the classic approaches in motor nerve transfer, as well as local and free muscle transfer, and described new ones, that aim to combine their advantages, particularly the simplification to a single stage and use of multiple reinnervation to the mimetic muscles. These advances are valuable to the reconstructive surgeon as powerful tools that can be tailored to the unique challenges of patients with facial nerve palsy looking for dynamic reanimation options.

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The effect of poly(lactic‐co‐glycolic acid) conduit loading insulin‐like growth factor 1 modified by a collagen‐binding domain on peripheral nerve injury in rats

Cited by 6 publications

References 25 publications

Shielding the Nerve: A Systematic Review of Nerve Wrapping to Prevent Adhesions in the Rat Sciatic Nerve Model

Shielding the Nerve: A Systematic Review of Nerve Wrapping to Prevent Adhesions in the Rat Sciatic Nerve Model

Use of Poly Lactic-co-glycolic Acid Nano and Micro Particles in the Delivery of Drugs Modulating Different Phases of Inflammation

Nerve guide conduits, nerve transfers, and local and free muscle transfer in facial nerve palsy

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