The effect of pleiotrophin signaling on adipogenesis

Gu, Dayong; Yu, Bing; Zhao, Chen; Fraser, Michael; Lv, Qing; Ma, Jiangan; Zhang, Yaou

doi:10.1016/j.febslet.2006.12.043

Cited by 45 publications

(51 citation statements)

References 40 publications

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“…As a growth factor, PTN stimulates the mitogenesis of fibroblasts, endothelial cells, and epithelial cells in culture, as well as neurite outgrowth in neonatal neuronal cells [51, 52]. Homeostasis of endometrial tissue plays an important role in the preparation of the uterus for each new estrous cycle or to support pregnancy [41].…”

Section: Resultsmentioning

confidence: 99%

miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression

Zhang

Liu

et al. 2017

PLoS ONE

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Increasing evidence has shown that miRNAs play important roles in endometrium development during the menstrual cycle in humans and many other animals. Our previous data indicated that miR-182 levels increase 15.55-fold and pleiotrophin (PTN) levels decrease 20.97-fold in the receptive endometrium (RE, D15) compared with the pre-receptive endometrium (PE, D5) in dairy goats. The present study shows that miR-182 is widely expressed in different tissues of dairy goats and that its expression levels are regulated by E2 and P4 in endometrial epithelium cells (EECs). We confirmed that PTN is a target of miR-182 and that miR-182 regulates the protein levels of AKT, Bcl-2, FAS, MAPK, Caspase-3 and SP1 in EECs. Furthermore, miR-182 up-regulates or maintains the expression levels of osteopontin (OPN), cyclooxygenase-2 (COX-2) and prolactin receptor (PRLR) in EECs, suggesting that miR-182 is an important regulatory factor in the construction of endometrial receptivity in dairy goats. In conclusion, miR-182 participates in the development of endometrial receptivity by down-regulating PTN and affecting the expression of select apoptosis-related genes and increasing or maintaining the expression levels of OPN, COX-2 and PRLR in the EECs of dairy goats.

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Section: Resultsmentioning

confidence: 99%

miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression

Zhang

Liu

et al. 2017

PLoS ONE

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“…For example, it was shown to promote the apoptotic response of cardiomyocytes through the inhibition of Akt signaling (55) and to inhibit angiogenesis by interfering with VEGF165 (56). Moreover, it has been shown that pleiotrophin negatively regulates adipogenesis (35). In addition, several publications have reported contradictory results concerning the activities of pleiotrophin.…”

Section: Discussionmentioning

confidence: 99%

Loss of Receptor Protein Tyrosine Phosphatase β/ζ (RPTPβ/ζ) Promotes Prostate Cancer Metastasis

Diamantopoulou

Kitsou

Ménashi

et al. 2012

Journal of Biological Chemistry

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Background:The role of pleiotrophin and its receptors RPTP␤/ and Syndecan-3 during tumor metastasis remains unknown. Results: RPTP␤/ knockdown initiates EMT, promotes pleiotrophin-mediated migration and attachment through Syndecan-3 and induces in vivo metastasis. Conclusion: RPTP␤/ plays a suppressor-like role in prostate cancer metastasis. Significance: Boosting RPTP␤/ or attenuating Syndecan-3 signaling pathways may lead to more effective therapeutic strategies in treating prostate cancer metastasis.

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“…10 Thus, Ptn increases the phosphorylation status of various substrates of Ptprz1, including Ctnnb1. 10,23,24 We and others have previously shown that Ctnnb1 is an important regulator of HSC self-renewal and differentiation. 4,25,26 However, coculture with Ptn-knockdown stromal cells did not affect Ctnnb1 expression, neither at the mRNA or at the protein level nor in the distribution between cytoplasm and nucleus in sorted LSK, CMP, or GMP from stromal cocultures.…”

Section: Discussionmentioning

confidence: 99%

Stromal pleiotrophin regulates repopulation behavior of hematopoietic stem cells

Istvànffy

Kröger

Eckl

et al. 2011

Blood

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IntroductionAll mature blood cells derive from HSCs. These HSCs have been shown to reside mainly in specialized microenvironments, referred to as niches. It is thought that the niche regulates HSC quiescence (dormancy), self-renewal, and differentiation by expression of surface molecules and secretion of soluble factors. Which signals are provided by the niche and how exactly these signals affect HSCs still remains uncertain. 1 We have established a number of stromal cell clones from mid gestation embryonic sources, of which we identified 2 cell lines (EL08-1D2 and UG26-1B6) which maintain fetal as well as adult HSCs, even though they had no direct contact with the hematopoietic cells (noncontact cocultures). 2,3 In gene expression studies, we observed that, in comparison to a number of nonsupporting stromal cell lines, those 2 cell lines both expressed larger amounts of mRNA corresponding to a number of secreted molecules. We recently described that one of these factors, secreted frizzledrelated protein 1, is required for sustained self-renewal of HSCs in vivo and that this was because of extrinsic regulation of HSCs by the microenvironment, most probably, through regulating ␤-catenin (Ctnnb1) and peroxisome proliferator-activated receptor ␥ (Pparg), both mediators of the Wnt signaling pathways. 4 One other overrepresented factor was the pleiotrophic cytokine pleiotrophin (Ptn). 3 Ptn was also found to be overexpressed by other HSC supportive cells, such as human brain endothelial cells 5,6 or the stromal cell line AFT024, 7 suggesting that high expression of Ptn may be a common feature among HSC-supportive stromal cells.Ptn, because of its pleiotrophic activities, is known under many alternative names, including heparin-binding growth-associated molecule and osteoblast-stimulating factor. Ptn is a highly conserved 17-kDa cytokine, 8 which, together with Midkine, forms a small family of low molecular weight factors. 9 Several receptors are known to bind Ptn as a ligand: receptor protein tyrosine phosphatase ␤/ (Rptpz1), 10 nucleolin, 11 and N-syndecan. 12 It was recently shown that Rptpz1 is expressed on BM-derived lineage Ϫ Ly6a ϩ Kit ϩ (LSK) cells. 6 Binding of Ptn to RPTP␤/ inactivates the phosphatase domain through dimerization of the receptor. This leads to an increasing phosphorylation status of the numerous targets of RPTP␤/, including ␤-catenin, ALK, ␤-adducin, CD81, c-Fyn, and others. 10,13 The effects of Ptn on proliferation and differentiation appear to converge in ␤-catenin and its downstream factor Dlk1. 10,14 Interestingly, Dlk1 has previously been identified to be overrepresented in the Ptn-overexpressing HSC-maintaining cell line AFT024 and to promote cobblestone area formation by HSC-derived progeny. 15 Because it was shown that Rptpz1 is expressed on BM-derived LSK cells, 6 these pathways may well be relevant in HSC regulation.Ptn is known to play important roles in proliferation and differentiation in various cell types. It was shown that Ptn is mitogenic for fibroblasts, epithelial, and endo...

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The effect of pleiotrophin signaling on adipogenesis

Cited by 45 publications

References 40 publications

miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression

miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression

Loss of Receptor Protein Tyrosine Phosphatase β/ζ (RPTPβ/ζ) Promotes Prostate Cancer Metastasis

Stromal pleiotrophin regulates repopulation behavior of hematopoietic stem cells

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