The effect of platelet-to-lymphocyte ratıo (PLR) and glasgow prognostıc score (GPS) on recurrence, and survıval ın patıents undergoıng lobectomy for early-stage non-small cell lung cancer (NSCLC)

Agaoglu Sanli, Bahar; Gulmez, Barıs; Yazgan, Serkan; Ucvet, Ahmet

doi:10.1007/s13304-023-01669-3

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…PLR is considered to be an accurate, easily detectable, and inexpensive marker for evaluating the prognosis of patients with NPC and guiding treatment decisions. In fact, elevated PLR levels can predict the prognosis of various tumors such as lung cancer ( Sanli et al, 2024 ), esophageal cancer ( Aoyama et al, 2022 ), and cervical cancer ( Gao et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Retrospective study of a novel hematological parameter for predicting the survival of patients with nasopharyngeal carcinoma

Tang,

Long

2024

PeerJ

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Purpose This study aims to explore the prognostic values of routine pre-treatment hematological parameters in patients with nasopharyngeal carcinoma (NPC). Methods The hematological parameters and clinical data of patients with NPC were collected from January 2012 to December 2013 at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. The survival statistics were obtained by regularly following-up the patients. The cut-off values for the hematological parameters were calculated using X-tile software. SPSS version 24.0 was used for the statistical analysis. The relationship between the hematological parameters and the prognosis of patients with NPC was analyzed using the Kaplan–Meier method and Cox multivariate regression. The discriminating abilities of the factors, which predict the prognosis, were evaluated by utilizing the receiver operating characteristic (ROC) area under the curve (AUC). Results This study included 179 patients with NPC. Multivariate analysis shows that pretreatment platelet-to-lymphocyte ratio (PLR; hazard ratio; HR = 0.44, 95% CI [0.21–0.91], p = 0.029), serum albumin (ALB; HR = 2.49, 95% CI [1.17–5.30], p = 0.018), and globulin (GLO; HR = 0.44, 95% CI [0.21–0.90], p = 0.024) are independent predictors for 5-year overall survival (OS) in patients with NPC. In addition, pre-treatment PLR (HR = 0.47, 95% CI [0.25–0.90], p = 0.022) and pre-treatment GLO (HR = 0.37, 95% CI [0.19–0.72], p = 0.001) are associated with 5-year progression-free survival (PFS) in patients with NPC. Based on the results of the multivariate analysis, we proposed a new biomarker GLO-PLR, which is observably correlated with the T stage, N stage and clinical stage in patients with NPC. The OS resolving ability of the GLO-PLR evaluated by AUC is 0.714, which is better than those of GLO and PLR. The PFS resolving ability of the GLO-PLR evaluated by AUC was 0.696, which is also better than those of GLO and PLR. Conclusion Pre-treatment PLR, ALB, and GLO are independent predictors of 5-year OS in patients with NPC, where PLR and GLO are also independent predictors of 5-year FPS. Compared with other hematological parameters, the proposed GLO-PLR is an inexpensive, effective, objective, and easy-to-measure marker for predicting the prognosis of NPC.

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Section: Discussionmentioning

confidence: 99%

Retrospective study of a novel hematological parameter for predicting the survival of patients with nasopharyngeal carcinoma

Tang,

Long

2024

PeerJ

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“…Lymphocytes, neutrophils (N), monocytes (M), and platelets (PLT), as important components of inflammatory factors in the tumor microenvironment, are important in the development and prognosis of common tumors ( 7 ). Several studies have demonstrated that biomarkers, including neutrophil-to-lymphocyte ratio (NLR) ( 8 ), platelet-to-lymphocyte ratio (PLR) ( 9 ), systemic immune-inflammation index (SII) ( 10 ), and systemic inflammation response index (SIRI) ( 11 ), predict the NSCLC prognosis, yet there is still a lack of a prognostic assessment tool encompassing other significant factors. Nutritional status affects key cellular and molecular processes underlying cancer phenotypes, and malnutrition can cause muscle loss and cachexia, as well as impair tolerance and response to cooperative antitumor therapy, increasing the risk of treatment interruption, and decreasing survival ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

A novel inflammatory nutrient index for predicting survival outcomes in patients with non-small cell lung cancer

Li,

Liu,

2024

Transl Cancer Res

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Background Lung cancer is one of the most common contributors to cancer-related deaths worldwide. This study aimed to develop a new blood index on the basis of the patient’s systemic inflammation and nutritional status, which can be used to predict the prognosis of patients with non-small cell lung cancer (NSCLC). Methods Pre-treatment blood markers were analyzed in 556 NSCLC patients from 2010 to 2019. A least absolute shrinkage and selection operator (LASSO) method was used to select indicators to establish a new integrated biomarker (PNAGR). Kaplan-Meier survival curves were used to assess the prognostic impact of platelet-to-lymphocyte ratio (PLR), albumin (ALB), and the PNAGR. The prognostic value was verified using univariate and multivariate Cox analyses. Results We used four biomarkers including PLR, ALB, 1/albumin-to-globulin ratio (1/AGR), and neutrophil/albumin-to-globulin ratio (N/AGR) were used to screen for the PNAGR using LASSO. Patients with high PNAGR demonstrated lower overall survival (OS) compared to those with low PNAGR. In both univariate and multivariate analyses, PNAGR was revealed as an independent prognostic factor for OS. The predictive power of PNAGR [area under the curve (AUC): 0.753] was higher than that of the metrics alone. Conclusions PNAGR is a novel and effective clinical prognostic tool with good clinical predictive value for NSCLC patients.

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NLR, MLR, and PLR are adverse prognostic variables for sleeve lobectomy within non‐small cell lung cancer

Han,

Zhang,

Hong

et al. 2024

Thoracic Cancer

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BackgroundThe goal of the research was to examine the value of peripheral blood indicators in forecasting survival and recurrence among people suffering central‐type non‐small cell lung cancer (NSCLC) undergoing sleeve lobectomy (SL).MethodsClinical information was gathered from 146 individuals suffering from NSCLC who had SL at our facility between January 2014 and May 2023. Peripheral blood neutrophil lymphocyte ratio (NLR), monocyte lymphocyte ratio (MLR), and platelet lymphocyte ratio (PLR) levels were determined by receiver operating characteristic (ROC) curve to establish the threshold points. Kaplan–Meier survival analysis was employed to evaluate the prognostic value of different groupings, and both univariate and multivariate Cox proportional hazards model (referred to as COX) were performed.ResultsThe disease‐free survival (DFS) and overall survival (OS) cutoff values were carried out via ROC analysis. Kaplan–Meier survival analysis revealed notable differences in OS for NLR (≥2.196 vs. <2.196, p = 0.0009), MLR (≥0.2763 vs. <0.2763, p = 0.0018), and PLR (≥126.11 vs. <126.11, p = 0.0354). Similarly, significant differences in DFS were observed for NLR (≥3.010 vs. <3.010, p = 0.0005), MLR (≥0.2708 vs. <0.2708, p = 0.0046), and PLR (≥126.11 vs. <126.11, p = 0.0028). Univariate Cox analysis showed that NLR (hazard ratio [HR]: 2.469; 95% confidence interval [CI]: 1.416–4.306, p < 0.001), MLR (HR: 2.192, 95% CI: 1.319–3.643, p = 0.002) and PLR (HR: 1.696, 95% CI: 1.029–2.795, p = 0.038) were correlated alongside OS. Multivariate Cox analysis showed that NLR (HR: 2.036, 95% CI: 1.072–3.864, p = 0.030) was a separate OS risk variable. Additionally, the pN stage (HR: 3.163, 95% CI: 1.660–6.027, p < 0.001), NLR (HR: 2.530, 95% CI: 1.468–4.360, p < 0.001), MLR (HR: 2.229, 95% CI: 1.260–3.944, p = 0.006) and PLR (HR: 2.249, 95% CI: 1.300–3.889, p = 0.004) were connected to DFS. Multivariate Cox analysis showed that pN stage (HR: 3.098, 95% CI: 1.619–5.928, p < 0.001) was a separate DFS risk variable.ConclusionThe study demonstrates that NLR, MLR, and PLR play a convenient and cost‐effective role in predicting survival and recurrence among individuals alongside central‐type NSCLC having SL.

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The effect of platelet-to-lymphocyte ratıo (PLR) and glasgow prognostıc score (GPS) on recurrence, and survıval ın patıents undergoıng lobectomy for early-stage non-small cell lung cancer (NSCLC)

Cited by 3 publications

References 34 publications

Retrospective study of a novel hematological parameter for predicting the survival of patients with nasopharyngeal carcinoma

Retrospective study of a novel hematological parameter for predicting the survival of patients with nasopharyngeal carcinoma

A novel inflammatory nutrient index for predicting survival outcomes in patients with non-small cell lung cancer

NLR, MLR, and PLR are adverse prognostic variables for sleeve lobectomy within non‐small cell lung cancer

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