The effect of platelet-rich plasma on fracture healing in long-bone pseudoarthrosis

Therapeutic Efficacy and Safety of Osteoinductive Factors and Cellular Therapies for Long Bone Fractures and Non-Unions: A Meta-Analysis and Systematic Review

“…Based on the inclusion criteria, 528 studies were excluded after reading the full article, while 861 and 126 studies were excluded because they were review articles or were written in languages other than English, respectively (Figure 1). Finally, 18 studies [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] published between 1996 and 2020 met our inclusion criteria. The data from each study are summarised in Tables 1 and 2.…”

“…Overall, eighteen studies (Table 1) [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] analysed the potential healing enhancement after intraoperative application of osteoinductive factors, such as BMPs, and PRP and osteogenetic factors (MSCs) in long bone fractures. Four studies [26,29,30,36] reported results from different anatomic locations [26,29] or osteoinductive factors [30] or doses of the applied factor [36].…”

“…All studies combined a broad spectrum of therapeutic techniques for fracture stabilisation such as intramedullary nailing (IMN), Ilizarov external fixation and open reduction and internal fixation (ORIF) and further osteoinductive and osteoconductive interventions such as autologous bone grafting. Furthermore, the efficacy of the applied factors in the enhancement of fracture healing was examined in close [10,24,34,37] and open fractures [21,22,27,32,34,36,37] as well as in non-union treatment [22][23][24][25][26][27][28][29][30][31]33,35,37,38].…”

“…Similarly, five studies [22,23,26,28,31] assessed the effectiveness of PRP in accelerating the process of osseous healing. One study evaluated the activity of PRP in pseudoarthrosis healing [22].…”

A case report of upper limb loss of substance: Use of functional gracilis free flap, brachioradialis transposition and bioglass for bone regeneration

“…Furthermore, sufficient mechanical stability is to be ensured with plate fixation to avoid minimal movement of the graft. The aim of our study is not talking about bone pseudoarthrosis treatment, which has widely been discussed in literature, both with bone graft [22] , or regenerative solution such as bioglass [18] , [19] , [20] , [21] , bone marrow aspirate concentrate [23] , platelet rich plasma [24] . Our objective is to let surgeon consider that the gracilis free flap may be considered as an ideal therapeutic option for reconstruction of upper limb lesions involving multiple tissue damage with loss of hand extension in view of its composite characteristics aforementioned as well as its ability to be innervated by a single motor nerve and tendon.…”