The effect of platelet-rich plasma injection on chronic Achilles tendinopathy and acute Achilles tendon rupture

Chen, Jianguo; Wan, Yingying; Jiang, Haiyue

doi:10.1080/09537104.2021.1961712

Cited by 6 publications

(4 citation statements)

References 51 publications

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“…Furthermore, there were no differences between the two cohorts in terms of increased tendon thickness and pain relief in people with Achilles tendinopathy. [15] The most recent meta-analysis used a visual analogue scale [VAS] in addition to VISA-A to measure outcomes. At 12 weeks after treatment initiation, VAS scores and tendon thickness were significantly different in favor of PRP.…”

Section: Achilles Tendinopathymentioning

confidence: 99%

Platelet-rich plasma as a new treatment method in orthopedics

Janocha,

Jerzak,

Hitnarowicz

et al. 2024

J Educ Health Sport

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Introduction and purposePlatelet-rich plasma (PRP) therapy represents a technology designed to enhance tissue repair by locally administering one's own bioactive agents, aiming to influence physiological processes like inflammation, angiogenesis, and extracellular matrix synthesis. Recently, the use of PRP therapy has become a subject of discussion in the orthopedic field. This review comprehensively examines the mechanisms, contemporary applications, clinical evidence, safety aspects, and potential future advancements of PRP in orthopedic treatment. Research has documented the efficacy of PRP injections in achieving full regeneration and enabling a comeback to competitive sports. PRP injections could serve as a viable alternative treatment for individuals with lateral tendonitis when compared to surgery. Further research investigating the impact of PRP on the bone healing process following a fracture is warranted. Materials and methods The methodology for conducting literature search involved utilizing medical subject headings terms to explore PubMed. Search terms included: "plasma-rich therapy", "tendinopathy", "injury" " articular cartilage ", "bone fracture " ConclusionsResearch at different evidence levels has shown that PRP is safe and has beneficial effects in above uses. Due to the autologous nature of the therapy, side effects are minimal. In the majority of cases, PRP therapy alleviates pain sensations in both short- and long-term observations, facilitating a faster return to daily functionality. However, additional randomized, controlled clinical trials are anticipated to be conducted in the future. Progressing further necessitates the standardization of methods for preparing plasma and procedures for its application.

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Section: Achilles Tendinopathymentioning

confidence: 99%

Platelet-rich plasma as a new treatment method in orthopedics

Janocha,

Jerzak,

Hitnarowicz

et al. 2024

J Educ Health Sport

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show abstract

“…Therefore, it can accurately compare the efficacies of PRP with different compositions and facilitate further exploration of optimal PRP ingredients. The concentration level for some other important growth factors, such as PDGF, TGF-β, and VEGF, should also be considered (Chen et al, 2022). PRP can maintain an anticoagulation state for up to 8 h. However, PRP must be activated to release platelet granule content to exert treatment effects.…”

Section: The Use Of Prp In Clinical Practice or Clinical Trialsmentioning

confidence: 99%

Platelet-rich plasma in the pathologic processes of tendinopathy: a review of basic science studies

Han

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

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Tendinopathy is a medical condition that includes a spectrum of inflammatory and degenerative tendon changes caused by traumatic or overuse injuries. The pathological mechanism of tendinopathy has not been well defined, and no ideal treatment is currently available. Platelet-rich plasma (PRP) is an autologous whole blood derivative containing a variety of cytokines and other protein components. Various basic studies have found that PRP has the therapeutic potential to promote cell proliferation and differentiation, regulate angiogenesis, increase extracellular matrix synthesis, and modulate inflammation in degenerative tendons. Therefore, PRP has been widely used as a promising therapeutic agent for tendinopathy. However, controversies exist over the optimal treatment regimen and efficacy of PRP for tendinopathy. This review focuses on the specific molecular and cellular mechanisms by which PRP manipulates tendon healing to better understand how PRP affects tendinopathy and explore the reason for the differences in clinical trial outcomes. This article has also pointed out the future direction of basic research and clinical application of PRP in the treatment of tendinopathy, which will play a guiding role in the design of PRP treatment protocols for tendinopathy.

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“…In a recent systematic review by Chen et al 8 examining the efficacy of platelet-rich plasma (PRP) injections for AT, PRP resulted in clinical improvement at 6 weeks of follow-up compared with placebo but no difference at 3 and 6 months of follow-up. Findings like these highlight the importance of longer-term studies to demonstrate any potential benefit to AMs compared to existing treatment modalities.…”

Section: Applications In Foot and Ankle Surgerymentioning

confidence: 99%

Contemporary Review: The Use of Human Placental Tissues in Foot and Ankle Surgery

Bagheri,

Anastasio,

Dmytruk

et al. 2023

Foot Ankle Int.

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The use of fetal tissues in regenerative medicine has long been a source of both promise and controversy. Since the turn of the century, their utilization has expanded because of antiinflammatory and analgesic properties, which have been theorized to act as an avenue for treating various orthopaedic conditions. With increased recognition and use, it is essential to understand the potential risks, efficacy, and long-term effects of these materials. Given the substantial body of literature published since 2015 (the date of the most recent review of fetal tissues in foot and ankle surgery), this manuscript provides an updated reference on the topic. Specifically, we evaluate the recent literature regarding the role of fetal tissues in wound healing, hallux rigidus, total ankle arthroplasty, osteochondral defects of the talus, Achilles tendinopathy, and plantar fasciitis.

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The effect of platelet-rich plasma injection on chronic Achilles tendinopathy and acute Achilles tendon rupture

Cited by 6 publications

References 51 publications

Platelet-rich plasma as a new treatment method in orthopedics

Platelet-rich plasma as a new treatment method in orthopedics

Platelet-rich plasma in the pathologic processes of tendinopathy: a review of basic science studies

Contemporary Review: The Use of Human Placental Tissues in Foot and Ankle Surgery

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