The Effect of Platelet-Rich Fibrin, Calcium Sulfate Hemihydrate, Platelet-Rich Plasma and Resorbable Collagen on Soft Tissue Closure of Extraction Sites

Abstract

Rapid and complete soft tissue healing after tooth extraction minimizes surgical complications and facilitates subsequent implant placement. We used four treatment methods and assessed changes in soft tissue socket closure following tooth extraction in humans. The effects of platelet-rich fibrin-calcium sulfate hemihydrate (PRF-CSH), platelet-rich plasma-calcium sulfate hemihydrate (PRP-CSH), a resorbable collagen dressing (RCD), and no grafting material were compared in a randomized, controlled pilot study with a blinded parallel design (N = 23). Patients with a hopeless tooth scheduled for extraction were randomly assigned to one of the four treatment groups. Socket measurements were obtained immediately after extraction and treatment, as well as after 21 days. There was a significant decrease in the total epithelialized external surface area of the extraction sockets in each group at all time points. However, there were no significant differences in soft tissue closure (p > 0.05) at any time point and PRF-CSH or PRP-CSH did not provide any additional benefit to enhance the soft tissue closure of extraction sockets compared with either RCD or sites without graft.

The use of bioactive factors to enhance bone regeneration: A narrative review

“…Moreover, the use of L‐PRF in third molars’ extractions has been associated with an improvement in second molars’ periodontal parameters (Kumar, Prasad, Ramanujam, Dexith & Chauhan, ) and a nearly tenfold decrease in the incidence of osteomyelitis compared to natural healing (Hoaglin & Lines, ). However, other RCTs and controlled studies did not confirm significant advantages when comparing L‐PRF to unassisted socket healing in terms of alveolar bone resorption and bone density (Girish Rao, Bhat, Nagesh, Rao & Mirle, ; Srinivas, Das, Rana, Qureshi & Vaidya, ; Zhang et al., ), periodontal parameters (Baslarli, Tumer, Ugur & Vatankulu, ), bone scintigraphy outcomes (Baslarli et al., ; Gurbuzer, Pikdoken, Urhan, Suer & Narin, ), post‐operative morbidities, prevention of dry socket and soft tissue closure (Asmael, Jamil & Hasan, ; Asutay, Yolcu, Gecor, Acar & Ozturk, ; Yerke, Jamjoom, Zahid & Cohen, ). Two case series quantified radiographically (CBCT) (Anwandter, Bohmann, Nally, Castro & Quirynen, ) and clinically (Simon, Gupta & Tajbakhsh, ) the ridge changes of L‐PRF‐treated sockets at 4 months of healing, which ranged between 0.03 mm and 0.67 mm in height, and between 1.33 mm and 0.57 mm in width.…”

Regeneración alveolar post extracción de remanente radicular mediante la aplicación de Plug y membrana de fibrina rica en plaquetas (FPR) . Reporte de un caso clínico

“…Yerke y cols. en su estudio demostraron que el uso de FRP como biomaterial para la regeneración ósea en alveolos dentarios postexodoncia tiene la propiedad de restablecer el mineral óseo de manera acelerada ya que logra grado de regeneración significativo a los 21 días de ser colocado cuando fisiológicamente se necesitan 130 días para alcanzar un grado mínimo admisible de regeneración (12). En el presente estudio se pudo comprobar que la aplicación de FRP resulta una técnica efectiva si de regeneración ósea se habla.…”

Soft-Tissue Healing Assessment after Extraction and Socket Preservation Using Platelet-Rich Fibrin (PRF) in Smokers: A Single-Blinded, Randomized, Controlled Clinical Trial

“…Four notches were made to represent the midpoints of the buccal, palatal, mesial, and distal dimensions of the tooth and served as reference points for socket dimension measurements. Furthermore, measurements were conducted by placing the probe exactly perpendicularly and at the mid-portion of the socket both bucco-palatally and mesio-distally on the stent and comparing changes in the inner part of the soft-tissue edges to the nearest 1 mm [ 32 ].…”