The effect of pituitary adrenocorticotrophic hormone (ACTH) on histamine intoxication and anaphylaxis in the guinea pig

The role of isoallergies in the production of experimental uveitis

“…They were unable to prevent anaphy-9* lactic shock by pretreating a group of the animals with cortisone. This finding was in agreement with other investigators who have noted that steroids have no effect in preventing anaphylactic reactions in guinea pigs (FRIEDLAENDER, 1950). By sensitizing rabbits intraocularly with homologous uveal tissue and shocking them intravenously with the homologous tissue several weeks later, Sum & DoDD (1955) were able to demonstrate inflammatory reactions in the anterior chamber of the sensitized eye.…”

ACTION OF PREDNISONE1, ON EXPERIMENTAL ASTHMA OF THE GUINEA PIG

“…According to Carrier & Code (4), Friediaender & Friedlaender (7), Schild et al (20), there is no evidence that ACTH and cortisone inhibit liberation of histamine under experimental conditions or that they affect its action once it has been released. These hormones apparently do not interfere on the action of histamine, introduced into the body or already liberated, but they seem to inhibit the biogenesis of histamine.…”

Effect of ACTH, corticoids and PCN (pregnenolone-16α-carbonitrile) on drug responses and disposition

“…ACTH and some natural glucocorticoids do not prevent bronchospasm, anaphylaxis, shock and mortality caused by histamine in guinea pigs (Friedlaender & Friedlaender, 1950;Malkiel, 1951) and rats (Schapiro, 1965).…”