The effect of piscidin antimicrobial peptides on the formation of Gram‐negative bacterial biofilms

Abstract

In fish production systems, Aeromonas hydrophila and Flavobacterium columnare have been found to readily form biofilms on fish mucosal surfaces and any number of inanimate substrates (Cai & Arias, 2017;Cai et al., 2019). Recent in vitro work has demonstrated that the presence of different teleost fish mucus extracts upregulates pathways associated with robust F. columnare biofilm development (Lange et al., 2018(Lange et al., , 2019. The persistence of A. hydrophila and F. columnare within production systems could lead to continuous disease problems (Hossain et al., 2014;Mohammed & Arias, 2014), as well as contribute to the potential overuse of therapeutics and, ultimately, to an increased incidence of antibiotic resistance among pathogens

A Comprehensive Review of Recent Research into the Effects of Antimicrobial Peptides on Biofilms—January 2020 to September 2023

“…Class II piscidins (piscidin 4 and piscidin 5) were found to be more potently active against Flavobacterium columnare and E. coli than class I Piscidins (piscidin 1 and piscidin 3), but class I Piscidins showed more growth inhibition of Aeromonas spp. [109].…”

Recent Advances of Composite Nanomaterials for Antibiofilm Application

“…In addition, when combined with kanamycin, it has a synergistic antibacterial effect and is a potential anti-biological film agent for the treatment of cystic fibrosis caused by P. aeruginosa biofilm. In addition, antimicrobial peptides such as Cec4 [15], piscidin [16] and CRAMP [17] are also successfully used in the field of antibiofilms. Although these natural antimicrobial agents have excellent bactericidal activities, they exhibit disadvantages including low stability in physiological environments, short antibacterial durations and poor permeability in biofilms [18], which limit their application in combatting biofilms.…”