The effect of pindolol, a beta-receptor blocking agent, in heart rate and blood-pressure during submaximal and maximal exercise

Gyntelberg, Finn; Persson, I; Frische, Louis H.; Ulrich, J

doi:10.1007/bf00635801

Eur J Clin Pharmacol

1972

DOI: 10.1007/bf00635801

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The effect of pindolol, a beta-receptor blocking agent, in heart rate and blood-pressure during submaximal and maximal exercise

Finn Gyntelberg

I Persson

Louis H. Frische

et al.

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1982

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Cited by 14 publications

(2 citation statements)

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“…Twenty-nine patients whose previous treatment was considered unsatisfactory became well controlled. Pindolol appears to be a useful antihypertensive in general practice.Pindolol is a proven hypotensive agent, Collins and King (1972), Feltham et al (1972, Gyntelberg et al (1972), Laver and Kincaid-Smith (1914), Morgan et al (1972. Clinical trials performed in hospitals often take place in conditions remote from those obtaining during the day to day management of patients in general practice.This study was performed to assess the usefulness of pindolol in family practitioner circumstances and to determine its long term efficacy.…”

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An Assessment of Pindolol in the General Practice Management of Hypertension

Davies¹

1976

Int J Clinical Practice

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confidence: 99%

“…Pindolol is a proven hypotensive agent, Collins and King (1972), Feltham et al (1972, Gyntelberg et al (1972), Laver and Kincaid-Smith (1914), Morgan et al (1972. Clinical trials performed in hospitals often take place in conditions remote from those obtaining during the day to day management of patients in general practice.…”

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confidence: 99%

An Assessment of Pindolol in the General Practice Management of Hypertension

Davies¹

1976

Int J Clinical Practice

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Effect of Pindolol on Blood Pressure, Plasma Renin Activity, and Catecholamines in Hypertensive Patients

Gavras

Tifft

et al. 1981

The Journal of Clinical Pharma

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The effects of 45 mg pindolol daily on blood pressure, heart rate, plasma renin activity, and plasma catecholamines were assessed on 11 hospitalized hypertensive patients. Blood pressure decreased significantly after nine days of treatment, but heart rate remained unchanged. Plasma renin activity was in the same average range before and during treatment, with individual values variably increasing, decreasing, or remaining unchanged. Blood pressure changes were independent from the baseline level of plasma renin activity or the change in renin activity observed during treatment. Plasma epinephrine and norepinephrine levels also remained unchanged during treatment. Lack of change in heart rate and hormonal levels may be attributed to the combined effects of the β‐antagonistic and partial agonistic properties of this agent. Thus, pindolol used as monotherapy at this dose significantly lowered blood pressure, but not to normal levels, with only minimal side effects. Because of its combined adrenergic agonistic and antagonistic effects, it may be a preferable alternative to pure antagonists in selected patients.

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Pindolol: A Review of Its Pharmacology, Pharmacokinetics, Clinical Uses, and Adverse Effects

Golightly¹

1982

Pharmacotherapy

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Pindolol is a new noncardioselective beta adrenergic blocking agent with intrinsic sympathomimetic activity. In the treatment of mild to moderate hypertension, pindolol provides effective control of blood pressure in a large majority of patients when administered alone or, more commonly, when combined with a thiazide diuretic. Pindolol is approximately as effective as propranolol in the therapy of hypertension, but in some crossover trials central nervous system side effects were more frequent with pindolol. A "ceiling effect" may be observed as dosages are titrated upward above approximately 20 to 30 mg per day, such that further blood pressure reductions may not be achievable. Some patients will exhibit a paradoxical increase in blood pressure with an increase in dosage. In patients who respond to modest doses of pindolol, twice or even once daily dosing is often adequate. This prolonged duration of hypotensive activity, while not suggested by the kinetics of this or similar drugs, is probably common to most beta blockers. Investigations in small numbers of patients with angina pectoris have reported variable but generally beneficial results with pindolol.

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The effect of pindolol, a beta-receptor blocking agent, in heart rate and blood-pressure during submaximal and maximal exercise

Cited by 14 publications

References 6 publications

An Assessment of Pindolol in the General Practice Management of Hypertension

An Assessment of Pindolol in the General Practice Management of Hypertension

Effect of Pindolol on Blood Pressure, Plasma Renin Activity, and Catecholamines in Hypertensive Patients

Pindolol: A Review of Its Pharmacology, Pharmacokinetics, Clinical Uses, and Adverse Effects

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