The effect of phytosterol protects rats against 4-nitrophenol-induced liver damage

Chen, Jiaqin; Song, Meiyan; Li, Yansen; Zhang, Yonghui; Taya, Kazuyoshi; Li, Chunmei

doi:10.1016/j.etap.2015.12.011

Cited by 29 publications

(15 citation statements)

References 28 publications

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“…Also, Chen et al (2016) have shown that phytosterin treatment protects the liver tissue from PNP's toxic effect. Mi et al (2013) have investigated histological examinations in testes and further indicated significant damage to the seminiferous epithelium and germ cell induced by PNP.…”

Section: Discussionmentioning

confidence: 99%

Potential protective effect of arginine against 4-nitrophenol-induced ovarian damage in rats

Dai

et al. 2016

J. Toxicol. Sci.

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-4-nitrophenol (PNP) is generally regarded as a diesel exhaust particle (DEP). Arginine plays an important role as a new feed additive, possessing highly efficient antioxidant activities. Here we investigated the effects of dietary supplementation with arginine against ovarian damage induced by PNP in rats. A total of thirty-two female rats postnatal day 28 (PND 28) were randomly divided into four groups. Two groups were fed with basal diet or 13 g/kg arginine in diet for 4 weeks, respectively; the other two groups were given PNP (100 mg/kg b.w.) daily by subcutaneous injection for 2 weeks following pretreatment with either basal diet or arginine diet for 2 weeks. The values of body weight gain (BWG), average daily gain (ADG) and percentage weight gain (PWG) upon PNP treatment were significantly reduced than those in other groups. The relative liver weight in the PNP group was significantly decreased compared with the control group. Treatment with PNP significant reduced the number of corpora lutea, although serum 17β-estradiol (E2) and progesterone (P4) concentrations were unchanged. The morphology of the ovaries in PNP-treated rats displayed necrosis, follicular deformation and granulosa cells irregular arrangement. Moreover, exposure to PNP enhanced production of malondialdehyde (MDA) and hydrogen peroxide (H 2 O 2 ), and decreased the activities of total superoxide dismutase (T-SOD) and catalase (CAT), and the co-administration of arginine can attenuate the oxidative stress caused by PNP. These results suggest that arginine may have a protective effect against ovarian damage induced by PNP owing to its antioxidant capacity effect.

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Section: Discussionmentioning

confidence: 99%

Potential protective effect of arginine against 4-nitrophenol-induced ovarian damage in rats

Dai

et al. 2016

J. Toxicol. Sci.

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“…PNP was dissolved in the vehicle (dimethyl sulfoxide, DMSO) to obtain a 1% v/v final concentration of DMSO in the dosing solution, which did not affect the control values of any of the experiments (Letelier et al ., ). The PNP groups were then treated with a daily dose of 200 mg kg –1 body weight by gavage for 1 or 3 days because our previous study clearly demonstrated that the subcutaneous injection of PNP (100 mg kg –1 ) to immature rats seriously impaired the liver (Chen et al ., ). Moreover, the oral median lethal dose (LD 50 ) of PNP is 500 mg kg –1 in rats (MHLW, ).…”

Section: Methodsmentioning

confidence: 97%

“…Several studies have shown that PNP affected the hypothalamus–pituitary–gonadal axis by disrupting hormonal balance and differentially modulating AR, ER‐α, and ‐β expression in male rat testes (Zhang et al ., ). Also, PNP caused oxidative damage in zebrafish (Lam et al ., ) and rats (Chen et al ., ). As an important industrial chemical, which is also used in agriculture, PNP is widely used in pesticides, herbicides, dyes, pharmaceuticals and other products.…”

Section: Introductionmentioning

confidence: 97%

“…In mammals, PNP can be metabolized in the liver by hepatic microsomal enzyme systems via glucuronidation, and sulfate esters are formed before it is excreted from the body (Mizuma et al ., ). Previous studies demonstrated that PNP induced liver damage in rats (Chen et al ., ; Li et al ., ). However, the exact mechanism underlying the liver damage induced by PNP is unknown.…”

Section: Introductionmentioning

confidence: 99%

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4‐Nitrophenol exposure alters the AhR signaling pathway and related gene expression in the rat liver

Song

et al. 2016

J of Applied Toxicology

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4-Nitrophenol (PNP) is well known as an environmental endocrine disruptor. The aim of this study was to clarify the mechanism of PNP-induced liver damage and determine the regulatory involvement of the aryl hydrocarbon receptor (AhR) signaling pathway and associated gene expression. Immature male Wistar-Imamichi rats (28 days old) were randomly divided into control and PNP groups, which consisted of 1- and 3-day exposure (1 DE and 3 DE, respectively) and 3-day exposure followed by 3-day recovery (3 DE + 3 DR), groups. Each group was administered the vehicle or PNP (200 mg kg body weight). The body and liver weight were significantly decreased in the 3 DE group. The mRNA expression levels of estrogen receptor-α (ERα), glutathione S-transferase (GST) and AhR exhibited a significant increase in the 1 DE group whereas, in contrast, that of cytochrome P450 (CYP) 1A1 decreased significantly in the 3 DE +3 DR group. AhR and CYP1A1 proteins were detected in the cytoplasm of hepatocytes of the 1 DE and 3 DE +3 DR groups whereas the ERα protein was found in the hepatocyte nuclei of the 1 DE and 3 DE groups. The present study demonstrates that PNP activated the AhR signaling pathway and regulated related CYP1A1 and GST gene expression in the liver. Copyright © 2016 John Wiley & Sons, Ltd.

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“…The antioxidative defense systems that include antioxidant enzymes like SOD, CAT, GPx simultaneously neutralize chemical reactive intermediates produced by endogenous pathways and/or xenobiotic metabolism [34]. SOD detoxifies superoxide radicals to hydrogen peroxide, CAT decomposes hydrogen peroxide to water and oxygen and GPx converts peroxides and hydroxyl radicals into non-toxic forms [35]. GSH constitutes the first line of defense against free radicals and plays an important role in Palanisamy and Samiappan the detoxification of electrophilic substances and prevention of cellular oxidative stress [36].…”

Section: Palanisamy and Samiappanmentioning

confidence: 99%

Antioxidant and Chemotherapeutic Potential of Curcuma Amada Rhizome Extract on Benzo(a)pyrene Induced Cervical Carcinoma in Sprague Dawley Rats

Devaraj

Samiappan²

2017

Asian J Pharm Clin Res

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Objective: To evaluate the antioxidant and chemotherapeutic potential of Curcuma amada Rhizome extract on benzo(a)pyrene (BaP) induced cervical carcinoma in Sprague Dawley rats.Methods: A total of 30 female Sprague Dawley rats were selected to establish cervical cancer model and then divided into 5 groups at random with six mice in each group. Group 1 control, Group 2 BaP (oral), Group 3 BaP for 8 weeks and post-treated with cisplatin (intravenous administration), Group 4 BaP for 8 weeks and post-treated with 250 mg of ethanol extract of C. amada (oral), Group 5 BaP for 8 weeks and post-treated with 500 mg of ethanol extract of C. amada (oral). 4 weeks after the treatment, the animals were sacrificed, serum separated, and cervical tissues were dissected. Antioxidants and the markers carcinoembryonic antigen (CEA), cancer antigens (CAs) 125, gamma glutamyltransferase (GTT) were assayed in serum and the tissue was used for analyzing tumor burden and sectioned for histopathological assays.10% tissue homogenate was estimated for antioxidants and membrane-bound enzymes.Results: BaP treated group showed significant (p<0.001) incidence of tumor burden, decreased activities of antioxidants, elevated lipid peroxidation, Na Conclusion:From the results, it can be concluded that C. amada Rhizome extract ameliorated BaP induced oxidative stress in the cervical carcinogenicity of rats.

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The effect of phytosterol protects rats against 4-nitrophenol-induced liver damage

Cited by 29 publications

References 28 publications

Potential protective effect of arginine against 4-nitrophenol-induced ovarian damage in rats

Potential protective effect of arginine against 4-nitrophenol-induced ovarian damage in rats

4‐Nitrophenol exposure alters the AhR signaling pathway and related gene expression in the rat liver

Antioxidant and Chemotherapeutic Potential of Curcuma Amada Rhizome Extract on Benzo(a)pyrene Induced Cervical Carcinoma in Sprague Dawley Rats

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