The Effect of Physical Activity on VEGF and HIF-1 Signaling

Ghahramani, Mehran; Majd, Z Razavi

doi:10.5812/jcrps.98493

Cited by 3 publications

(1 citation statement)

References 15 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the GAS and TA muscles of Cpt1a KO mice had a reduction in mRNA levels of angiogenesis markers ( Vegf and Hif1a ), that could mimick the natural process that occurs during aging or may be a consequence of muscle mass loss. A reduction in mRNA levels of these genes influences oxygen transport and muscle cell function; however, this effect is not observed Cpt1a KO mice (Mehran Ghahramani, 2020 ). This fact highlights that other compensatory processes could be involved, such as the activation of SNS, changes in AgRP neuronal activity, or muscle mass reduction.…”

Section: Discussionmentioning

confidence: 99%

Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice

Ibeas,

Griñán‐Ferré,

del Mar Romero

et al. 2023

Aging Cell

View full text Add to dashboard Cite

Orexigenic neurons expressing agouti‐related protein (AgRP) and neuropeptide Y in the arcuate nucleus (ARC) of the hypothalamus are activated in response to dynamic variations in the metabolic state, including exercise. We previously observed that carnitine palmitoyltransferase 1a (CPT1A), a rate‐limiting enzyme of mitochondrial fatty acid oxidation, is a key factor in AgRP neurons, modulating whole‐body energy balance and fluid homeostasis. However, the effect of CPT1A in AgRP neurons in aged mice and during exercise has not been explored yet. We have evaluated the physical and cognitive capacity of adult and aged mutant male mice lacking Cpt1a in AgRP neurons (Cpt1a KO). Adult Cpt1a KO male mice exhibited enhanced endurance performance, motor coordination, locomotion, and exploration compared with control mice. No changes were observed in anxiety‐related behavior, cognition, and muscle strength. Adult Cpt1a KO mice showed a reduction in gastrocnemius and tibialis anterior muscle mass. The cross‐sectional area (CSA) of these muscles were smaller than those of control mice displaying a myofiber remodeling from type II to type I fibers. In aged mice, changes in myofiber remodeling were maintained in Cpt1a KO mice, avoiding loss of physical capacity during aging progression. Additionally, aged Cpt1a KO mice revealed better cognitive skills, reduced inflammation, and oxidative stress in the hypothalamus and hippocampus. In conclusion, CPT1A in AgRP neurons appears to modulate health and protects against aging. Future studies are required to clarify whether CPT1A is a potential antiaging candidate for treating diseases affecting memory and physical activity.

show abstract

Section: Discussionmentioning

confidence: 99%

Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice

Ibeas,

Griñán‐Ferré,

del Mar Romero

et al. 2023

Aging Cell

View full text Add to dashboard Cite

show abstract

Whole Body Vibration Training Has No Effect on Vascular Endothelial and Inflammatory Markers in Young Healthy Women

Gattner,

Adamiak,

Czerwińska-Ledwig

et al. 2024

JCM

View full text Add to dashboard Cite

Background: The aim of the study was to comparatively assess the impact of single and repeated whole body vibration training (WBVT) and training without vibration on changes in the concentration of vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), and high-sensitivity C-reactive protein (hsCRP) in healthy, young, non-training women. Methods: The study involved 46 women (age 20.48 ± 1.72 years), who were divided into three groups: the experimental group participating in WBVT (EVG, n = 17); the comparison group performing the same exercises but without the vibration factor (EXG, n = 12); and the control group, which did not participate in any training (CON, n = 17). The program included participation in 36 training sessions conducted over 12 weeks, with a frequency of 3 times per week. In the EVG and EXG groups, venous blood was collected before and after the first and last training sessions, while in the CON group, blood was collected twice at a 3-month interval. Results: No significant changes were observed in the concentrations of the studied markers either after a single or repeated training session in both experimental groups (p > 0.05). Conclusions: The proposed WBVT protocol appears to be a safe form of exercise that does not induce negative inflammatory reactions. The applied vibration stimulus combined with physical exercises did not initiate pro-angiogenic processes or stimulate eNOS activity in healthy women, suggesting that similar studies should be conducted in individuals with circulatory problems or chronic inflammatory diseases.

show abstract

The effect of high-intensity interval training and quercetin nanoliposome consumption on angiogenesis indexes in the heart tissue of myocardial infarction rats

Zaheri Abdehvand,

Jalali Dehkordi,

Taghian

2023

Hormozgan medical journal

View full text Add to dashboard Cite

Background: Myocardial infarction is the death of the heart muscle tissue that causes tissue damage and inflammation. Quercetin consumption and interval training can probably prevent the progression of this condition in the active parts of the myocardium by activating angiogenesis pathways and stimulating hypoxia factor-1a (HIF-1a) at the onset of infarction. Objectives: This study investigates the effect of high-intensity interval training and quercetin nanoliposome consumption on angiogenesis indexes in the heart tissue of myocardial infarction rats. Methods: In this experimental study, 30 male rats weighing 250 ± 20 g were randomly divided into five groups including: 1) myocardial infarction + training, 2) myocardial infarction + supplement, 3) myocardial infarction + training + supplement, 4) healthy control, and 5) myocardial infarction. Myocardial infarction was induced by subcutaneous injection of soprenaline hydrochloride at a dose of 80 mg / kg. Groups 2 and 3 received quercetin daily at a dose of 0.25 mg / kg body weight by gavage. Groups 1 and 3 performed 5 sessions of training protocol per week for 8 weeks. The Smirnov-Kolmogorov, one-way analysis of variance and Tukey’s post hoc test were used to analyze the data and the alpha level less than 0.05 was considered as a significant level. Results: Interval training and quercetin supplementation had a significant effect on increasing VEGF and HIF-1a gene expression (P=0.0009). Conclusion: The combined effect of interval training and quercetin consumption may prevent the progression of myocardial infarction by activating angiogenesis factors VEGF and HIF-1a in the early stages, and may play an effective role in preventing this disease.

show abstract

The Effect of Physical Activity on VEGF and HIF-1 Signaling

Cited by 3 publications

References 15 publications

Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice

Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice

Whole Body Vibration Training Has No Effect on Vascular Endothelial and Inflammatory Markers in Young Healthy Women

The effect of high-intensity interval training and quercetin nanoliposome consumption on angiogenesis indexes in the heart tissue of myocardial infarction rats

Contact Info

Product

Resources

About