The Effect of Phycocyanin Isolated from Arthrospira platensis on the Oxidative Stress in Yeasts

Rogov, A. G.; Sergeeva, Ya. E.; Sukhinov, D. V.; Ivaschenko, M. V.; Kuvyrchenkova, A. P.; Vasilov, R. G.

doi:10.1134/s2635167623010111

Cited by 2 publications

(2 citation statements)

References 39 publications

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“…Since Saccharomyces cerevisiae is a useful model organism for studying aging and agingassociated diseases, we used this yeast to study the anti-aging properties of phycocyanin purified from the cyanobacterium A. platensis. Phycocyanin has been shown to reduce oxidative stress in both mammals and the aerobic yeast Yarrowia lipolytica [14,15]. Interestingly, we show that cells treated with phycocyanin at the time of inoculation, while being longer-lived than untreated cells, show a higher level of ROS than the untreated cells themselves, suggesting that phycocyanin might favour survival by enhancing the level of ROS in S. cerevisiae.…”

Section: Discussionmentioning

confidence: 64%

“…Phycocyanin is considered responsible for the A. platensis anti-cancer, anti-inflammatory and antioxidant activities [11][12][13]. In particular, phycocyanin has been shown to reduce oxidative stress in both yeast and mammals [14,15]. Moreover, data in the literature showed that the antioxidant properties of phycocyanin might arise from both radical scavenging and metal chelation [16].…”

Section: Introductionmentioning

confidence: 99%

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Unraveling the Anti-Aging Properties of Phycocyanin from the Cyanobacterium Spirulina (Arthrospira platensis)

Nova,

Citterio,

Martegani

et al. 2024

IJMS

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In recent years, marine natural products have become one of the most important resources of novel lead compounds for critical diseases associated with age. Spirulina, a dietary supplement made from blue-green algae (cyanobacteria: scientific name Arthrospira platensis), is particularly rich in phycocyanin, a phycobiliprotein, which accounts for up to 20% of this cyanobacterium’s dry weight and is considered responsible for its anti-cancer, anti-inflammatory and antioxidant activities. Although the anti-aging activity of phycocyanin has been investigated, how exactly this compound works against aging remains elusive. The aim of our research is to use the yeast Saccharomyces cerevisiae as a model organism to investigate the anti-aging properties of phycocyanin from A. platensis. Our results show that phycocyanin has a powerful anti-aging effect, greatly extending the chronological life span of yeast cells in a dose-dependent way, as the effect was also pronounced when cells were grown in SD medium under calorie restriction conditions (0.2% glucose). Both ROS and accumulation of dead cells were followed by staining chronologically aged cells with dihydrorhodamine 123 (DHR123) and propidium iodide (PI). Interestingly, we found that most of the aged phycocyanin-treated cells, which were unable to form colonies, were actually ROS+/PI–. Finally, we show that the moment in which phycocyanin is added to the culture does not substantially influence its effectiveness in counteracting chronological aging.

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Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Unraveling the Anti-Aging Properties of Phycocyanin from the Cyanobacterium Spirulina (Arthrospira platensis)

Nova,

Citterio,

Martegani

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Unraveling the Anti-aging Properties of Phycocyanin from the Cyanobacterium Spirulina (Arthrospira platensis)

Nova,

Citterio,

Martegani

et al. 2024

Preprint

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In recent years, marine natural products have become one of the most important resources of novel lead compounds for critical diseases associated with age. Spirulina, a dietary supplement made from blue-green algae (cyanobacteria: scientific name Arthrospira platensis), is particularly rich in phycocyanin, a phycobiliprotein, which accounts for up to 20% of this cyanobacterium’s dry weight and is considered responsible for its anti-cancer, anti-inflammatory and antioxidant activities. Although the anti-aging activity of phycocyanin has been investigated, how exactly this compound works against aging remains elusive. Aim of our research is to use the yeast Saccharomyces cerevisiae as a model organism to investigate the anti-aging properties of phycocyanin from A. platensis. Our results show that phycocyanin has a powerful anti-aging effect, greatly extending the chronological life span of yeast cells in a dose-dependent way, being the effect pronounced also when cells were grown in SD medium under calorie restriction conditions (0.2% glucose). Both ROS and accumulation of dead cells were followed by staining chronologically aged cells with dihydrorhodamine 123 (DHR123) and propidium iodide (PI). Interestingly, we found that most of the aged phycocyanin treated cells, which were unable to form colonies, were actually ROS+/PI–. Finally, we show that the moment in which phycocyanin is added to the culture does not substantially influence its effectiveness in counteracting chronological aging.

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The Effect of Phycocyanin Isolated from Arthrospira platensis on the Oxidative Stress in Yeasts

Cited by 2 publications

References 39 publications

Unraveling the Anti-Aging Properties of Phycocyanin from the Cyanobacterium Spirulina (Arthrospira platensis)

Unraveling the Anti-Aging Properties of Phycocyanin from the Cyanobacterium Spirulina (Arthrospira platensis)

Unraveling the Anti-aging Properties of Phycocyanin from the Cyanobacterium Spirulina (Arthrospira platensis)

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