The effect of phosphatidylserine administration on memory and symptoms of attention‐deficit hyperactivity disorder: a randomised, double‐blind, placebo‐controlled clinical trial

Hirayama, S.; Terasawa, Katsutoshi; Rabeler, R.; Hirayama, T.; Inoue, Toshitada; Tatsumi, Yasuhisa; Purpura, Martin; Jäger, Ralf

doi:10.1111/jhn.12090

Cited by 60 publications

(41 citation statements)

References 28 publications

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“…PS supplement significantly enhances brain cell membrane fluidity, promote glucose metabolism in brain cells, and improves the physiological activities of protein kinase C, acetylcholinesterase, tyrosine hydroxylase, and Na + -K + -ATP enzymes in the brain, and maintains the normal information transmission between nerve cells. Thus, brain cells are more active and brain structural deficiency due to brain fatigue and malnutrition were prevented with PS treatment (Manor et al, 2012;Hirayama et al, 2014;Schmid et al, 2014). The present results showed that AD patients taking 300 mg PS/day for 20 continuous weeks significantly improved vocabulary and picture scores, which is consistent with clinical trial results showing that taking PS can improve memory in many healthy or memory impaired subjects.…”

Section: Discussionsupporting

confidence: 80%

Effect of phosphatidylserine on memory in patients and rats with Alzheimer’s disease

Zhang¹,

Yang²,

Guo³

2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to investigate the effect of phosphatidylserine (PS) on memory of patients and rats with Alzheimer's disease (AD). In total, 57 AD patients were recruited from our hospital, and were divided into two groups: 25 in the control group and 32 in the observation group. Next, 300 mg/d of PS was given to the rats in the observation group for 12 continuous weeks based on the control group. AD rats were divided into three groups: control group, PS 30 mg/kg group, and PS 15 mg/kg group. Learning memory ability and free radical levels in the brain were detected after treatment. In AD patients, vocabulary and picture matching scores in the two treatment groups increased after treatment (P < 0.05). Moreover, the scores in the treated group were significantly greater than the control group (P < 0.05). In AD rats, PS treatment reduced the escape latent period of AD rats, increased SOD and OH -, and decreased acetylcholinesterase levels (P < 0.05). Compared with PS 15 mg/kg, PS 30 mg/kg group was significantly more efficacious (P < 0.05). Compared with the AD model group, hippocampal cells showed normal arrangement, karyopyknosis decreased, and the pathological changes in the two PS groups were considerable. In conclusion, PS decreased cholinesterase, improved memory, and improved hippocampal inflammation injury in AD brains by increasing SOD and OH -levels.

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Section: Discussionsupporting

confidence: 80%

Effect of phosphatidylserine on memory in patients and rats with Alzheimer’s disease

Zhang¹,

Yang²,

Guo³

2015

Genet. Mol. Res.

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“…Apart from placental extracts, there have been many reports on dietary supplements, such as phosphatidylserine, plasmalogen, ferulic acid, curcumin, docosahexaenoic acid, and flavonoids, which have shown beneficial effects in aged humans and rodents (Barberger‐Gateau et al, ; Braverman & Moser., ; Hirayama et al, ; Mori, Koyama, Guillot‐Sestier, Tan, & Town, ; Rendeiro, Guerreiro, Williams, & Spencer, ; Yang et al, ). Despite an abundance of dietary supplements, they have often been shown to be ineffective in humans (Tan et al, ).…”

Section: Discussionmentioning

confidence: 99%

Porcine placental extract facilitates memory and learning in aged mice

Yamauchi

Tone

Sugimoto

et al. 2019

Food Science & Nutrition

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Aging induces a decline in both memory and learning ability without predisposing an individual to diseases of the central nervous system, such as dementia. This decline can have a variety of adverse effects on daily life, and it can also gradually affect the individual and the people they are surrounded by. Since recent evidence indicated that placental extract has effects on brain function such as memory, we hypothesized that placental extract could ameliorate the age‐associated reduction in cognitive function in aging. Here, we investigated the effect of new modified porcine placental extract (SD‐F) on memory ability in aged mice at both the behavioral and molecular levels. Our results revealed that SD‐F significantly enhanced memory ability in the object recognition and object location tasks in a dose‐dependent manner in aged mice relative to controls. The numbers of Nissl‐positive cells in the hippocampal cornu ammonis 3 (CA3) and dentate gyrus (DG) regions were increased in SD‐F‐treated aged mice relative to controls. RNA‐seq analysis of the hippocampus of aged mice identified 542 differentially expressed genes, of which 216 were up‐regulated and 326 were down‐regulated in SD‐F‐treated mice relative to controls. Of the 216 up‐regulated genes, we identified four characteristic genes directly related to memory, including early growth response protein 1 (Egr1), growth arrest and DNA‐damage‐inducible, beta (Gadd45b), NGFI‐A binding protein 2 (Nab2), and vascular endothelial growth factor a (Vegfa). These results suggest that the efficacy of SD‐F involves upregulation of these genes.

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“…PS supplementation promotes a desirable hormonal balance for athletes and might attenuate the physiological deterioration that accompanies overtraining and/or overstretching (Starks et al, 2008). In recent studies, PS has been shown to enhance mood in a cohort of young people during mental stress and to improve accuracy during tee-off by increasing the stress resistance of golfers (Hirayama et al, 2006). First pilot studies indicate that PS supplementation might be beneficial for children with attention-deficit hyperactivity disorder (Vaisman et al ., 2008).…”

Section: Resultsmentioning

confidence: 99%

Lipid composition of the brains of she-goat and castrated goat consumed in Ekiti State, Nigeria

Adeyeye

Adesina

2015

Bangladesh J. Sci. Ind. Res.

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The levels of fatty acids, phospholipids and sterols were determined in the brains of she-goat and castrated goat found in Ekiti State, Nigeria by gas chromatography. Results showed that the crude fat levels were 9.98 and 10.2 % in the brains of she-goat and castrated goat respectively. The fatty acid composition of she-goat and castrated goat brain shows that the SFA was 40.6 and 42.7 %, MUFA was 37.1 and 38.7 % and PUFA was 20.9 and 22.3% respectively. The other parameters of she-goat and castrated goat brain were found: PUFA/SFA, 0.490 and 0.548; MUFA/SFA, 0.869 and 0.953; n-6/n-3, 0.775 and 11.7; LA/ALA, 0.876 and 28.0; AA/DGLA, 6.05 and 17.4; EPA/DHA, 1.00 and 5.89 and EPSI (PUFA/MUFA), 0.564 and 0.575 respectively. Phospholipids were present in she-goat and castrated goat with a value range of 2365 and 3047 mg/100g respectively. Among the sterols, only cholesterol was of any significant level with values of 1353 mg/100g (she-goat brain) and 1355 mg/100g (castrated goat brain). Linear correlation at α = 0.05, df: n-1 showed that no significant difference exists between the crude fats, phospholipids and sterols except in the fatty acids parameters.

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The effect of phosphatidylserine administration on memory and symptoms of attention‐deficit hyperactivity disorder: a randomised, double‐blind, placebo‐controlled clinical trial

Cited by 60 publications

References 28 publications

Effect of phosphatidylserine on memory in patients and rats with Alzheimer’s disease

Effect of phosphatidylserine on memory in patients and rats with Alzheimer’s disease

Porcine placental extract facilitates memory and learning in aged mice

Lipid composition of the brains of she-goat and castrated goat consumed in Ekiti State, Nigeria

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