The effect of pharmacological doses of different antioxidants on oxidation parameters and atherogenesis in hyperlipidaemic rabbits

Djahansouzi, S.; Braesen, Jan Hinrich; Koenig, Kai; Beisiegel, Ulrike; Kontush, Anatol

doi:10.1016/s0021-9150(00)00510-4

Cited by 18 publications

(11 citation statements)

References 54 publications

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“…Several studies of New Zealand white rabbits fed a cholesterol-rich diet supplemented with ␣-tocopherol have reported lower TPC concentrations compared with animals consuming low levels of dietary ␣-tocopherol (57-59, 61, 70, 71, 79), although two studies reported no change in TPC concentration (54,74). In the absence of added cholesterol, ␣-tocopherol does not lower TPC (1,(75)(76)(77). In this study, the non-HDL fraction, e.g., VLDL, IDL, and LDL, underwent the greatest reduction with dietary ␣-tocopherol supplementation as has been reported in other studies (57,58,72).…”

Section: Discussionmentioning

confidence: 99%

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α-Tocopherol protects against diet induced atherosclerosis in New Zealand white rabbits

Schwenke

Rudel

Sorci‐Thomas

et al. 2002

Journal of Lipid Research

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In this study, we asked the question "does ␣ -tocopherol supplementation prevent an increase in total plasma cholesterol (TPC) concentration and reduce the deposition of cholesterol in arterial plaques of rabbits fed atherogenic diets?" Isocaloric diets containing 0.1% cholesterol to induce atherosclerosis were enriched in one of three fats: saturated fats (SAT), monounsaturated fats (MONO), or n-6 polyunsaturated fats (POLY). Half of each of the three diets were supplemented with 2,500 IU ␣ -tocopherol/kg-diet. Unsupplemented diets contained 25 IU ␣ -tocopherol/kg-diet. Rabbits supplemented with ␣ -tocopherol had plasma ␣ -tocopherol concentrations 10-fold higher and an average TPC concentration 31% lower, P ‫؍‬ 0.017, than rabbits fed unsupplemented diets. Among the three fat-fed groups, the difference was greatest for the POLY fat fed group (54%, P ‫؍‬ 0.041). POLY fat-fed rabbits without ␣ -tocopherol supplementation had plasma HDL cholesterol concentrations that were less than half that of rabbits fed other fats, P р 0.0001. In general, differences in mean esterified artery cholesterol concentrations among the three fat-fed groups, with and without ␣ -tocopherol supplementation, paralleled differences in TPC concentration among the groups.This study suggests that for rabbits fed high pharmacological doses of ␣ -tocopherol, atherosclerosis can be diminished in situations where the plasma cholesterol concentrations are also significantly lower. -Schwenke, D. C., L. L. Rudel, M. G. Sorci-Thomas, and M. J. Thomas. ␣ -Tocopherol protects against diet induced atherosclerosis in New Zealand white rabbits.

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Section: Discussionmentioning

confidence: 99%

“…Two studies reported no change in TPC concentrations in both male and female New Zealand white rabbits (54,74). In the absence of added cholesterol, ␣ -tocopherol did not lower the TPC concentration (1,(75)(76)(77). ␣ -Tocopherol supplementation did not prevent lesion development in injured rabbit arteries but did reduce lipid peroxidation (78).…”

mentioning

confidence: 99%

α-Tocopherol protects against diet induced atherosclerosis in New Zealand white rabbits

Schwenke

Rudel

Sorci‐Thomas

et al. 2002

Journal of Lipid Research

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“…26 However, when administered at pharmacological dosages, vitamin E has been shown to be ineffective in inhibiting atherosclerosis. 27 There may be problems with supplementation of vitamin E alone, because there seems to be a coregulation of metabolism or absorption of antioxidant supplements. 27,28 For example, supplementation with vitamin E lowered the plasma levels of ubiquinol-10, another antioxidant.…”

Section: Summary Of Veaps Findingsmentioning

confidence: 99%

“…27 There may be problems with supplementation of vitamin E alone, because there seems to be a coregulation of metabolism or absorption of antioxidant supplements. 27,28 For example, supplementation with vitamin E lowered the plasma levels of ubiquinol-10, another antioxidant. 28 Even high doses of vitamin E failed to show antioxidant activity in healthy humans.…”

Section: Summary Of Veaps Findingsmentioning

confidence: 99%

Alpha-Tocopherol Supplementation in Healthy Individuals Reduces Low-Density Lipoprotein Oxidation but Not Atherosclerosis

et al. 2002

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Background-Epidemiological studies have demonstrated an inverse relationship between vitamin E intake and cardiovascular disease (CVD) risk. In contrast, randomized controlled trials have reported conflicting results as to whether vitamin E supplementation reduces atherosclerosis progression and CVD events. Methods and Results-The study population consisted of men and women Ն40 years old with an LDL cholesterol level Ն3.37 mmol/L (130 mg/dL) and no clinical signs or symptoms of CVD. Eligible participants were randomized to DL-␣-tocopherol 400 IU per day or placebo and followed every 3 months for an average of 3 years. The primary trial end point was the rate of change in the common carotid artery far-wall intima-media thickness (IMT) assessed by computer image-processed B-mode ultrasonograms. A mixed effects model using all determinations of IMT was used to test the hypothesis of treatment differences in IMT change rates. Compared with placebo, ␣-tocopherol supplementation significantly raised plasma vitamin E levels (PϽ0.0001), reduced circulating oxidized LDL (Pϭ0.03), and reduced LDL oxidative susceptibility (PϽ0.01). However, vitamin E supplementation did not reduce the progression of IMT over a 3-year period compared with subjects randomized to placebo. Conclusions-The results are consistent with previous randomized controlled trials and extend the null results of vitamin E supplementation to the progression of IMT in healthy men and women at low risk for CVD.

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“…Muitos estudos em animais vêm usando altas doses de antioxidantes, mostrando ser efetivos agentes antiateroscleróticos quando dados em doses farmacológicas [11,36,18,17]. Vitaminas E e C são consideradas os mais importantes nutrientes antioxidantes, e sua deficiência está associada ao aumento de riscos de doenças coronárias [29].…”

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Caracterização e avaliação sensorial de barra de cereais funcional de alto teor protéico e vitamínico

Freitas¹,

Moretti²

2006

Ciênc. Tecnol. Aliment.

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Barras de cereais foram introduzidas há cerca de uma década como uma alternativa "saudável" de confeito, quando consumidores se mostravam mais interessados em saúde e dietas [5]. Alternativa saudável às barras de chocolate, o produto foi direcionado no Brasil inicialmente aos adeptos de esportes radicais e, com o tempo, conquistou até executivos de banco.Empresas nacionais disputam um mercado de R$ 80 milhões [3]. Atualmente, enquanto no Brasil consomem-se US$ 4 milhões de barras de cereais por ano, os Estados Unidos dão conta de US$ 2,9 bilhões, sendo que o consu- RESUMOBarras de cereais foram introduzidas no mercado há cerca de uma década como alternativa "saudável" de confeito. Concomitantemente, alimentos como a soja, ricos em vitaminas e minerais e com propriedades antioxidantes vêm recebendo grande aplicação em produtos de alegação funcional, pois previnem contra doenças cardiovasculares e crônico-degenerativas. Considerando o crescimento do segmento de barra de cereais no setor de alimentos, desenvolveu-se uma formulação de barra de cereais de alto teor protéico e vitamínico, à base de proteína de soja texturizada, gérmen de trigo e aveia, enriquecida de ácido ascórbico e acetato de α-tocoferol. As matérias-primas e a formulação final da barra de cereais foram submetidas a análises para caracterização e três formulações, variando o teor de ácido ascórbico, foram avaliadas quanto à preferência sensorial e intensidade ideal de doçura e acidez. A proteína de soja texturizada utilizada apresentou elevados teores dos oligossacarídeos rafinose e estaquiose (1,92 g/100 g e 4,66 g/100 g) e de isoflavonas totais (283,49 mg/100 g) se comparados ao grão, farinha integral e isolado protéico. A formulação final da barra de cereais apresentou 15,31% de proteína e elevado teor de vitamina E (118,0 mg/100 g) e minerais como fósforo, ferro e manganês. A formulação adicionada de 1,1 g/100 g de ácido ascórbico obteve maior preferência sensorial diferindo das demais amostras (p≤0,05). Palavras-chave: barra de cereais, proteína de soja, gérmen de trigo, preferência sensorial. SUMMARYCHARACTERIZATION AND SENSORIAL EVALUATION OF FUNCTIONAL CEREAL BAR. Cereal bars were introduced over a decade ago as a "healthy" alternative confectionery. Concomitantly, foods as soybean, with high vitamin and mineral levels and antioxidants properties come receiving great application in functional products, because they can prevent against chronic-degenerative illnesses of the heart. Considering the growth of the segment of cereal bars in the food sector, it was developed a formulation with high protein and vitamin levels cereal bar based on textured soy protein, wheat germ and oat, enriched with acid ascorbic and acetate of α-tocoferol. The cereal bar and its ingredients had been submitted to the analyses for characterization and three formulations, varying the content of acid ascorbic; they had also been evaluated as a sensorial preference and an ideal intensity of sweetness and acidity. The textured soy protein used presented high levels of ...

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The effect of pharmacological doses of different antioxidants on oxidation parameters and atherogenesis in hyperlipidaemic rabbits

Cited by 18 publications

References 54 publications

α-Tocopherol protects against diet induced atherosclerosis in New Zealand white rabbits

α-Tocopherol protects against diet induced atherosclerosis in New Zealand white rabbits

Alpha-Tocopherol Supplementation in Healthy Individuals Reduces Low-Density Lipoprotein Oxidation but Not Atherosclerosis

Caracterização e avaliação sensorial de barra de cereais funcional de alto teor protéico e vitamínico

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