The effect of pharmacologic erection on the dorsal nerve of the penis

Yang, Claire C.; Bradley, William E.; Berger, Richard E.

doi:10.1002/(sici)1097-4598(199711)20:11<1439::aid-mus12>3.0.co;2-x

Cited by 14 publications

(3 citation statements)

References 19 publications

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“…Some studies have suggested that the length of the penile shaft affects dorsal penile nerve latency. 18 – 20 Herbaut et al . 19 and Kiwamoto et al .…”

Section: Discussionmentioning

confidence: 99%

The sensitivity difference between the glans penis and penile shaft in primary premature ejaculation

Jiang

et al. 2023

Asian Journal of Andrology

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The penis is a vital organ of perception that transmits perceived signals to ejaculation-related centers. The penis consists of the glans penis and penile shaft, which differ considerably in both histology and innervation. This paper aims to investigate whether the glans penis or the penile shaft is the main source of sensory signals from the penis and whether penile hypersensitivity affects the whole organ or only part of it. The thresholds, latencies, and amplitudes of somatosensory evoked potentials (SSEPs) were recorded in 290 individuals with primary premature ejaculation using the glans penis and penile shaft as the sensory areas. The thresholds, latencies, and amplitudes of SSEPs from the glans penis and penile shaft in patients were significantly different (all P < 0.0001). The latency of the glans penis or penile shaft was shorter than average (indicating hypersensitivity) in 141 (48.6%) cases, of which 50 (35.5%) cases were sensitive in both the glans penis and penile shaft, 14 (9.9%) cases were sensitive in the glans penis only, and 77 (54.6%) cases were sensitive in the penile shaft only (P < 0.0001). There are statistical differences in the signals perceived through the glans penis and the penile shaft. Penile hypersensitivity does not necessarily mean that the whole penis is hypersensitive. We classify penile hypersensitivity into three categories, namely, glans penis, penile shaft, and whole-penis hypersensitivity, and we propose the new concept of penile hypersensitive zone.

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“…Some studies have suggested that the length of the penile shaft affects dorsal penile nerve latency. 18 – 20 Herbaut et al . 19 and Kiwamoto et al .…”

Section: Discussionmentioning

confidence: 99%

The sensitivity difference between the glans penis and penile shaft in primary premature ejaculation

Jiang

et al. 2023

Asian Journal of Andrology

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show abstract

“…Penile length and circumference have been shown to increase approximately 46% and 25%, respectively, with erection. 11,12 Previous studies concluded that electrodiagnostic measurements of the DNP in the flaccid penis were not as precise as those obtained in the erect penis, since the undulations in the DNP are diminished in erect penis. 12 With a pharmacologic erection, however, responses from more proximal portions of the urethra were still difficult to record due to electrode proximity and conduction block.…”

Section: Discussionmentioning

confidence: 99%

“…We do not believe that the medication used to induce erection resulted in changes in axonal excitability. 12 Two 10-mm (0.4 mm diameter) monopolar needle electrodes were placed subdermally at the base of the penis. Previous dissections showed the DNP to be a single trunk on both sides of the dorsal midline at the penile base.…”

Section: Methodsmentioning

confidence: 99%

Innervation of the human anterior urethra by the dorsal nerve of the penis

Yang¹,

Bradley²

1998

Muscle Nerve

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Previous neuroanatomic studies have demonstrated that branches of the dorsal nerve of the penis (DNP) innervate the anterior urethra. This study utilized electrodiagnostic techniques to confirm this finding. The portion of the male urinary tract distal to the prostate and genitourinary diaphragm is known as the anterior urethra. The innervation of the anterior urethra in the cat has been shown to be mediated through branches of the pudendal nerve. 1,9 The somatosensory innervation of the human penis is mediated primarily through the dorsal nerve of the penis (DNP). The DNP provides for afferent input from the skin of the penis and is crucially involved in male sexual reflex pathways for erection and ejaculation. 2,3,5 In neuroanatomic studies in the human, branches of the DNP were observed to penetrate the corpus spongiosum to innervate the urethra. This report is an electrodiagnostic study on the somatic innervation of the human anterior urethra by the DNP. These data clarify how urethral afferent information contributes to reflex sexual function, particularly ejaculation. METHODSTen healthy male volunteers aged 29-45 years (mean age 33) were enrolled in this study after protocol approval from the University of Washington Human Subjects Review Committee. None of the subjects had any physical evidence of penile neuropathy or history of genitourinary surgery, and all reported normal urinary and sexual function.Ten minutes prior to electrodiagnostic testing, a pharmacologic erection was induced by intracorporeal injection of alprostadil (prostaglandin E 1 ) 0.4 mL at the lateral base of the penis. This was done to increase the surface area of the penis and urethral length, which facilitated the electrode placement and positioning. Attempts to perform electrodiagnostic testing in subjects without an erection resulted in inconsistent results, primarily as a result of the inability to keep the catheter and electrodes in a fixed position within the urethra. Electrodiagnostic testing was commenced after the attainment of full tumescence and at approximately 50% rigidity of the subject's usual erectile capacity. Penile length was measured in the erect state from the base of the penis to the corona. We do not believe that the medication used to induce erection resulted in changes in axonal excitability. 12Two 10-mm (0.4 mm diameter) monopolar needle electrodes were placed subdermally at the base of the penis. Previous dissections showed the DNP to be a single trunk on both sides of the dorsal midline at the penile base. As the nerves traveled distally on the penile shaft, ventrolateral radiations of fibers emanated from the midline trunks (Yang and Bradley, submitted for publication). The electrodes were positioned so that they overlay the main trunks of both DNPs, perpendicular to the direction of the nerves. They were aligned along the dorsal midline of the penis with the anode positioned 1 cm

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Innervation of the human anterior urethra by the dorsal nerve of the penis

Yang

Bradley

1998

Muscle Nerve

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Previous neuroanatomic studies have demonstrated that branches of the dorsal nerve of the penis (DNP) innervate the anterior urethra. This study utilized electrodiagnostic techniques to confirm this finding. Electrical stimulation of the urethra resulted in responses recorded in the main trunk of the DNP, and responses were recorded from the urethra following stimulation of the DNP. A bulbocavernosus reflex was evoked after urethral stimulation. Urethral afferent impulses have a role in reflex ejaculatory function. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:514–518, 1998.

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The effect of pharmacologic erection on the dorsal nerve of the penis

Cited by 14 publications

References 19 publications

The sensitivity difference between the glans penis and penile shaft in primary premature ejaculation

The sensitivity difference between the glans penis and penile shaft in primary premature ejaculation

Innervation of the human anterior urethra by the dorsal nerve of the penis

Innervation of the human anterior urethra by the dorsal nerve of the penis

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